Annotations: 1ZEI

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1zeia_	Small proteins	Insulin-like	Insulin-like	Insulin-like	Insulin	pig (Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
B	d1zeib_	Small proteins	Insulin-like	Insulin-like	Insulin-like	Insulin	pig (Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
C	d1zeic_	Small proteins	Insulin-like	Insulin-like	Insulin-like	Insulin	pig (Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
D	d1zeid_	Small proteins	Insulin-like	Insulin-like	Insulin-like	Insulin	pig (Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
E	d1zeie_	Small proteins	Insulin-like	Insulin-like	Insulin-like	Insulin	pig (Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
F	d1zeif_	Small proteins	Insulin-like	Insulin-like	Insulin-like	Insulin	pig (Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Insulin-like	8025718	4003135	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Insulin-like	8038097	3000307	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Insulin-like	8038097	3000307	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Insulin-like	8038097	3000307	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Insulin-like	8038097	3000307	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Insulin-like	8038097	3000307	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Insulin-like	8038097	3000307	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Insulin	e1zeiA1	A: few secondary structure elements	X: Insulin-like (From Topology)	H: Insulin-like (From Topology)	T: Insulin-like	F: Insulin	ECOD (1.6)
B	Insulin	e1zeiB1	A: few secondary structure elements	X: Insulin-like (From Topology)	H: Insulin-like (From Topology)	T: Insulin-like	F: Insulin	ECOD (1.6)
C	Insulin	e1zeiC1	A: few secondary structure elements	X: Insulin-like (From Topology)	H: Insulin-like (From Topology)	T: Insulin-like	F: Insulin	ECOD (1.6)
D	Insulin	e1zeiD1	A: few secondary structure elements	X: Insulin-like (From Topology)	H: Insulin-like (From Topology)	T: Insulin-like	F: Insulin	ECOD (1.6)
E	Insulin	e1zeiE1	A: few secondary structure elements	X: Insulin-like (From Topology)	H: Insulin-like (From Topology)	T: Insulin-like	F: Insulin	ECOD (1.6)
F	Insulin	e1zeiF1	A: few secondary structure elements	X: Insulin-like (From Topology)	H: Insulin-like (From Topology)	T: Insulin-like	F: Insulin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.100.10	Mainly Alpha	Orthogonal Bundle	Insulin-like, subunit E	Insulin-like	CATH (4.3.0)
B	1.10.100.10	Mainly Alpha	Orthogonal Bundle	Insulin-like, subunit E	Insulin-like	CATH (4.3.0)
C	1.10.100.10	Mainly Alpha	Orthogonal Bundle	Insulin-like, subunit E	Insulin-like	CATH (4.3.0)
D	1.10.100.10	Mainly Alpha	Orthogonal Bundle	Insulin-like, subunit E	Insulin-like	CATH (4.3.0)
E	1.10.100.10	Mainly Alpha	Orthogonal Bundle	Insulin-like, subunit E	Insulin-like	CATH (4.3.0)
F	1.10.100.10	Mainly Alpha	Orthogonal Bundle	Insulin-like, subunit E	Insulin-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00049	Insulin/IGF/Relaxin family (Insulin)	Insulin/IGF/Relaxin family	Superfamily includes insulins; relaxins; insulin-like growth factor; and bombyxin. All are secreted regulatory hormones. Disulfide rich, all-alpha fold. Alignment includes B chain, linker (which is processed out of the final product), and A chain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	INSULIN	protein binding binding signaling receptor binding insulin receptor binding identical protein binding insulin-like growth factor receptor binding enzyme binding protease binding molecular transducer activity molecular function activator activity signaling receptor activity signaling receptor activator activity hormone activity molecular function regulator activity protein binding binding signaling receptor binding insulin receptor binding identical protein binding insulin-like growth factor receptor binding enzyme binding protease binding molecular transducer activity molecular function activator activity signaling receptor activity signaling receptor activator activity hormone activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity	negative regulation of protein transport protein localization regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of cellular process regulation of protein localization transport negative regulation of biological process negative regulation of transport protein localization to extracellular region localization regulation of secretion by cell secretion by cell negative regulation of protein transport protein localization regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of cellular process regulation of protein localization transport negative regulation of biological process negative regulation of transport protein localization to extracellular region localization regulation of secretion by cell secretion by cell negative regulation of secretion cellular macromolecule localization negative regulation of cellular process negative regulation of secretion by cell negative regulation of protein localization regulation of biological process regulation of transport secretion biological regulation regulation of establishment of protein localization establishment of protein localization to extracellular region negative regulation of establishment of protein localization export from cell regulation of protein transport protein secretion establishment of localization regulation of protein secretion regulation of secretion negative regulation of protein secretion protein transport regulation of cellular localization macromolecule localization cellular process negative regulation of small molecule metabolic process oxoacid metabolic process ketone metabolic process regulation of lipid metabolic process organic acid metabolic process regulation of primary metabolic process regulation of small molecule metabolic process small molecule metabolic process fatty acid metabolic process negative regulation of fatty acid metabolic process negative regulation of metabolic process carboxylic acid metabolic process primary metabolic process regulation of ketone metabolic process regulation of fatty acid metabolic process metabolic process monocarboxylic acid metabolic process regulation of metabolic process negative regulation of lipid metabolic process lipid metabolic process positive regulation of DNA replication positive regulation of biological process nucleobase-containing compound metabolic process positive regulation of metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process positive regulation of nucleobase-containing compound metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process DNA replication positive regulation of DNA metabolic process macromolecule metabolic process regulation of DNA metabolic process regulation of DNA replication lipid biosynthetic process organic acid biosynthetic process carboxylic acid biosynthetic process positive regulation of fatty acid biosynthetic process positive regulation of biosynthetic process positive regulation of lipid metabolic process positive regulation of fatty acid metabolic process regulation of biosynthetic process monocarboxylic acid biosynthetic process small molecule biosynthetic process fatty acid biosynthetic process biosynthetic process positive regulation of lipid biosynthetic process regulation of fatty acid biosynthetic process regulation of lipid biosynthetic process positive regulation of small molecule metabolic process multicellular organismal process T cell activation immune system process cell activation alpha-beta T cell activation lymphocyte activation leukocyte activation positive regulation of organelle organization regulation of cellular component organization positive regulation of cellular component organization regulation of mitotic nuclear division positive regulation of mitotic nuclear division mitotic cell cycle cellular component organization regulation of mitotic cell cycle positive regulation of cell cycle process cellular component organization or biogenesis cell cycle regulation of cell cycle cell cycle process mitotic nuclear division regulation of cell cycle process organelle fission positive regulation of nuclear division regulation of organelle organization positive regulation of cell cycle organelle organization nuclear division mitotic cell cycle process regulation of nuclear division monosaccharide metabolic process carbohydrate metabolic process hexose metabolic process glucose metabolic process carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process glycoprotein metabolic process macromolecule biosynthetic process protein metabolic process positive regulation of molecular function regulation of molecular function positive regulation of hydrolase activity regulation of catalytic activity regulation of hydrolase activity positive regulation of catalytic activity positive regulation of lipoprotein lipase activity positive regulation of lipase activity positive regulation of triglyceride lipase activity cellular response to stimulus cellular response to nitrogen compound positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling response to peptide hormone regulation of signal transduction insulin receptor signaling pathway regulation of cellular response to insulin stimulus cell surface receptor protein tyrosine kinase signaling pathway cell communication positive regulation of response to stimulus cellular response to endogenous stimulus response to hormone signal transduction enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus positive regulation of cellular response to insulin stimulus regulation of signaling cell surface receptor signaling pathway response to endogenous stimulus regulation of insulin receptor signaling pathway positive regulation of insulin receptor signaling pathway response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus regulation of response to stimulus response to chemical response to insulin regulation of cell communication cellular response to insulin stimulus positive regulation of signaling positive regulation of respiratory burst respiratory burst regulation of respiratory burst acute-phase response defense response response to stress inflammatory response acute inflammatory response nitric oxide mediated signal transduction cGMP-mediated signaling intracellular signal transduction nitric oxide-cGMP-mediated signaling intracellular signaling cassette catabolic process energy derivation by oxidation of organic compounds carbohydrate catabolic process regulation of generation of precursor metabolites and energy regulation of polysaccharide metabolic process macromolecule catabolic process glucan metabolic process polysaccharide metabolic process regulation of glycogen catabolic process glycogen catabolic process regulation of carbohydrate metabolic process negative regulation of carbohydrate metabolic process negative regulation of glycogen metabolic process negative regulation of macromolecule metabolic process negative regulation of catabolic process regulation of carbohydrate catabolic process glucan catabolic process glycogen metabolic process generation of precursor metabolites and energy regulation of catabolic process negative regulation of glycogen catabolic process polysaccharide catabolic process energy reserve metabolic process regulation of glycogen metabolic process negative regulation of protein catabolic process negative regulation of protein metabolic process regulation of protein metabolic process protein catabolic process regulation of protein catabolic process protein localization to cell periphery protein localization to plasma membrane regulation of protein localization to cell periphery localization within membrane protein localization to membrane regulation of protein localization to plasma membrane regulation of protein localization to membrane lipid catabolic process regulation of lipid catabolic process negative regulation of lipid catabolic process response to acid chemical response to L-arginine response to amino acid chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis lipoprotein biosynthetic process lipoprotein metabolic process positive regulation of protein localization to nucleus regulation of protein localization to nucleus protein localization to nucleus protein localization to organelle positive regulation of protein localization ribonucleotide catabolic process pyridine nucleotide catabolic process organophosphate catabolic process positive regulation of phosphate metabolic process nucleoside phosphate catabolic process regulation of ATP metabolic process regulation of purine nucleotide catabolic process positive regulation of nucleotide catabolic process glycolytic process regulation of phosphate metabolic process regulation of nucleotide metabolic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process purine ribonucleotide catabolic process phosphorus metabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process pyruvate metabolic process positive regulation of phosphorus metabolic process purine nucleoside diphosphate metabolic process purine-containing compound catabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process positive regulation of ATP metabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of phosphorus metabolic process regulation of nucleotide catabolic process positive regulation of carbohydrate metabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process ATP metabolic process positive regulation of nucleotide metabolic process positive regulation of purine nucleotide catabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process ribonucleoside triphosphate metabolic process nucleotide catabolic process purine nucleoside triphosphate metabolic process purine nucleotide catabolic process carbohydrate derivative catabolic process positive regulation of glycolytic process ADP catabolic process regulation of glycolytic process purine-containing compound metabolic process positive regulation of purine nucleotide metabolic process positive regulation of catabolic process ADP metabolic process organophosphate metabolic process purine ribonucleoside diphosphate metabolic process purine ribonucleoside diphosphate catabolic process regulation of intracellular signal transduction regulation of nitric oxide mediated signal transduction positive regulation of intracellular signal transduction positive regulation of nitric oxide mediated signal transduction reactive oxygen species biosynthetic process reactive oxygen species metabolic process regulation of reactive oxygen species biosynthetic process negative regulation of reactive oxygen species metabolic process negative regulation of reactive oxygen species biosynthetic process negative regulation of biosynthetic process regulation of reactive oxygen species metabolic process positive regulation of macromolecule biosynthetic process positive regulation of glycogen metabolic process carbohydrate biosynthetic process positive regulation of glucose metabolic process positive regulation of glycogen biosynthetic process regulation of macromolecule biosynthetic process regulation of glycogen biosynthetic process glucan biosynthetic process regulation of glucan biosynthetic process regulation of glucose metabolic process polysaccharide biosynthetic process glycogen biosynthetic process regulation of polysaccharide biosynthetic process regulation of carbohydrate biosynthetic process lactate biosynthetic process lactate metabolic process regulation of amino acid metabolic process amino acid metabolic process dendritic spine maintenance cell projection organization cellular component maintenance regulation of dendritic spine maintenance positive regulation of dendritic spine maintenance regulation of synapse structure or activity positive regulation of cell projection organization synapse organization regulation of biological quality plasma membrane bounded cell projection organization dendritic spine organization postsynapse organization regulation of cell projection organization regulation of postsynapse organization regulation of synapse organization cell junction organization neuron projection organization regulation of plasma membrane bounded cell projection organization negative regulation of proteolysis regulation of proteolysis proteolysis regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation regulation of tube diameter system process regulation of tube size circulatory system process vascular process in circulatory system blood vessel diameter maintenance vasodilation blood circulation regulation of anatomical structure size positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade positive regulation of establishment of protein localization positive regulation of secretion by cell positive regulation of protein transport positive regulation of secretion positive regulation of protein secretion positive regulation of transport fatty acid homeostasis lipid homeostasis positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion regulation of defense response negative regulation of acute inflammatory response regulation of response to external stimulus negative regulation of inflammatory response negative regulation of response to stimulus response to external stimulus regulation of inflammatory response negative regulation of response to external stimulus regulation of response to stress negative regulation of defense response regulation of acute inflammatory response wound healing response to wounding regulation of immune effector process regulation of cell differentiation response to biotic stimulus regulation of cell development regulation of respiratory burst involved in inflammatory response cell differentiation anatomical structure development regulation of immune system process developmental process respiratory burst involved in defense response immune response response to other organism regulation of innate immune response negative regulation of immune response negative regulation of immune effector process immune effector process defense response to other organism respiratory burst involved in inflammatory response regulation of immune response negative regulation of respiratory burst involved in inflammatory response negative regulation of multicellular organismal process regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of developmental process cellular developmental process negative regulation of response to biotic stimulus cell development negative regulation of respiratory burst innate immune response regulation of multicellular organismal process response to external biotic stimulus production of molecular mediator involved in inflammatory response defense response to symbiont negative regulation of immune system process negative regulation of innate immune response gluconeogenesis negative regulation of gluconeogenesis monosaccharide biosynthetic process hexose biosynthetic process regulation of gluconeogenesis cytokine production regulation of cytokine production gene expression regulation of gene expression positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of cytokine production G protein-coupled receptor signaling pathway negative regulation of gene expression negative regulation of macromolecule biosynthetic process hexose transmembrane transport D-glucose import carbohydrate transport positive regulation of D-glucose transmembrane transport positive regulation of transmembrane transport regulation of D-glucose import positive regulation of D-glucose import transmembrane transport regulation of transmembrane transport D-glucose transmembrane transport regulation of D-glucose transmembrane transport monosaccharide transmembrane transport carbohydrate transmembrane transport negative regulation of feeding behavior negative regulation of behavior feeding behavior regulation of behavior behavior regulation of feeding behavior neuron projection maintenance positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of protein modification process positive regulation of protein phosphorylation protein modification process protein phosphorylation protein autophosphorylation phosphorylation regulation of protein autophosphorylation macromolecule modification regulation of phosphorylation positive regulation of protein autophosphorylation	cellular anatomical structure extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR004825	Insulin	Family
A, B, C, D, E A, B, C, D, E, F	IPR022353	Insulin, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F	IPR036438	Insulin-like superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR022352	Insulin family	Family
A, B, C, D, E A, B, C, D, E, F	IPR016179	Insulin-like	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.