Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
D [auth A]SCOP2 FamilyDNA polymerase beta, N-terminal domain-like 8025470 4001032 SCOP2 (2022-06-29)
D [auth A]SCOP2 FamilyDNA polymerase beta-like, second domain 8025471 4002153 SCOP2 (2022-06-29)
D [auth A]SCOP2 FamilyDNA polymerase beta-like 8025473 4001836 SCOP2 (2022-06-29)
D [auth A]SCOP2 SuperfamilyDNA polymerase beta, N-terminal domain-like 8037849 3000524 SCOP2 (2022-06-29)
D [auth A]SCOP2 SuperfamilyPsbU/PolX domain-like 8037850 3000893 SCOP2 (2022-06-29)
D [auth A]SCOP2 SuperfamilyNucleotidyltransferase-like 8037852 3000129 SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
D [auth A]DNA_pol_lambd_fe2bcqA1 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: SAM domain-likeF: DNA_pol_lambd_fECOD (1.6)
D [auth A]HHH_8e2bcqA2 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: SAM domain-likeF: HHH_8ECOD (1.6)
D [auth A]DNA_pol_B_palme2bcqA3 A: a+b three layersX: Nucleotidyltransferase-likeH: Nucleotidyltransferase (From Topology)T: NucleotidyltransferaseF: DNA_pol_B_palmECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
D [auth A]1.10.150.110 Mainly Alpha Orthogonal Bundle DNA polymerase domain 1CATH (4.3.0)
D [auth A]1.10.150.20 Mainly Alpha Orthogonal Bundle DNA polymerase domain 1CATH (4.3.0)
D [auth A]3.30.460.10 Alpha Beta 2-Layer Sandwich Beta Polymerase domain 2CATH (4.3.0)
D [auth A]3.30.210.10 Alpha Beta 2-Layer Sandwich Beta Polymerase domain 3CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
D [auth A]PF14716Helix-hairpin-helix domain (HHH_8)Helix-hairpin-helix domain- Domain
D [auth A]PF14791DNA polymerase beta thumb (DNA_pol_B_thumb)DNA polymerase beta thumb- Family
D [auth A]PF14792DNA polymerase beta palm (DNA_pol_B_palm)DNA polymerase beta palmThe catalytic region of DNA polymerase beta is split into three domains. An N-terminal fingers domain, a central palm domain and a C-terminal thumb domain. This entry represents the palm domain [1].Domain
D [auth A]PF10391Fingers domain of DNA polymerase lambda (DNA_pol_lambd_f)Fingers domain of DNA polymerase lambdaDNA polymerases catalyse the addition of dNMPs onto the 3-prime ends of DNA chains. There is a general polymerase fold consisting of three subdomains that have been likened to the fingers, palm, and thumb of a right hand. DNA_pol_lambd_f is the centr ...DNA polymerases catalyse the addition of dNMPs onto the 3-prime ends of DNA chains. There is a general polymerase fold consisting of three subdomains that have been likened to the fingers, palm, and thumb of a right hand. DNA_pol_lambd_f is the central three-helical region of DNA polymerase lambda referred to as the F and G helices of the fingers domain. Contacts with DNA involve this conserved helix-hairpin-helix motif in the fingers region which interacts with the primer strand. This motif is common to several DNA binding proteins and confers a sequence-independent interaction with the DNA backbone [1].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
B [auth P]5'-D(*CP*AP*GP*TP*AP*CP*G)-3'---
A [auth D]5'-D(P*GP*CP*CP*G)-3'---
C [auth T]5'-D(*CP*GP*GP*CP*CP*GP*TP*TP*AP*CP*TP*G)-3'---
D [auth A]DNA polymerase lambda

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
D [auth A]PharosQ9UGP5