Annotations: 2CSK

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2cska1	Alpha and beta proteins (a+b)	PX domain	PX domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2cska3	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2cska2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	PX domain	8084570	4003533	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PX domain	8084571	3001006	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PX	e2cskA1	A: a+b two layers	X: PX domain (From Topology)	H: PX domain (From Topology)	T: PX domain	F: PX	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.1520.10	Alpha Beta	2-Layer Sandwich	PX Domain	Phox-like domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00787	PX domain (PX)	PX domain	PX domains bind to phosphoinositides.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Sorting nexin 12	binding phospholipid binding lipid binding phosphatidylinositol binding phosphatidylinositol-3-phosphate binding phosphatidylinositol phosphate binding protein binding enzyme binding	cellular localization transport intracellular transport late endosome to Golgi transport establishment of localization vesicle-mediated transport endosomal transport localization cytosolic transport retrograde transport, endosome to Golgi establishment of localization in cell cellular process Golgi vesicle transport regulation of protein maturation cellular localization transport intracellular transport late endosome to Golgi transport establishment of localization vesicle-mediated transport endosomal transport localization cytosolic transport retrograde transport, endosome to Golgi establishment of localization in cell cellular process Golgi vesicle transport regulation of protein maturation negative regulation of proteolysis regulation of cellular process negative regulation of protein maturation negative regulation of biological process regulation of primary metabolic process protein maturation regulation of proteolysis proteolysis negative regulation of cellular process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process regulation of protein metabolic process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of protein processing protein processing metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process negative regulation of protein processing regulation of localization import into cell regulation of cellular component organization regulation of transport regulation of vesicle-mediated transport cellular component organization cellular component organization or biogenesis endocytosis regulation of endocytosis negative regulation of protein transport protein localization establishment of protein localization nitrogen compound transport regulation of protein localization negative regulation of transport cellular macromolecule localization negative regulation of protein localization regulation of establishment of protein localization negative regulation of establishment of protein localization regulation of protein transport protein transport regulation of cellular localization macromolecule localization catabolic process macromolecule catabolic process negative regulation of protein catabolic process negative regulation of catabolic process protein catabolic process regulation of catabolic process regulation of protein catabolic process localization within membrane endocytic recycling vesicle-mediated transport to the plasma membrane regulation of intracellular transport negative regulation of intracellular transport vesicle-mediated transport between endosomal compartments regulation of early endosome to late endosome transport early endosome to late endosome transport negative regulation of early endosome to late endosome transport	membrane-bounded organelle intracellular anatomical structure early endosome endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle cytoplasm vesicle protein-containing complex membrane-bounded organelle intracellular anatomical structure early endosome endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle cytoplasm vesicle protein-containing complex membrane membrane protein complex retromer complex endosome membrane early endosome membrane cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001683	Phox homology	Domain
A	IPR036871	PX domain superfamily	Homologous Superfamily
A	IPR051074	Sorting Nexin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9UMY4	breast cancer ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.