2D3T

Fatty Acid beta-oxidation multienzyme complex from Pseudomonas Fragi, Form V

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C	d2d3tc2	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Thiolase-related	Fatty oxidation complex beta subunit (3-ketoacyl-CoA thiolase), C-terminal domain	(Pseudomonas fragi ) [TaxId: 296 ],	SCOPe (2.08)
C	d2d3tc1	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Thiolase-related	Fatty oxidation complex beta subunit (3-ketoacyl-CoA thiolase), N-terminal domain	(Pseudomonas fragi ) [TaxId: 296 ],	SCOPe (2.08)
D	d2d3td2	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Thiolase-related	Fatty oxidation complex beta subunit (3-ketoacyl-CoA thiolase), C-terminal domain	(Pseudomonas fragi ) [TaxId: 296 ],	SCOPe (2.08)
D	d2d3td1	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Thiolase-related	Fatty oxidation complex beta subunit (3-ketoacyl-CoA thiolase), N-terminal domain	(Pseudomonas fragi ) [TaxId: 296 ],	SCOPe (2.08)
A	d2d3ta1	All alpha proteins	6-phosphogluconate dehydrogenase C-terminal domain-like	6-phosphogluconate dehydrogenase C-terminal domain-like	HCDH C-domain-like	Fatty oxidation complex alpha subunit, C-terminal domain	(Pseudomonas fragi ) [TaxId: 296 ],	SCOPe (2.08)
A	d2d3ta3	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	6-phosphogluconate dehydrogenase-like, N-terminal domain	Fatty oxidation complex alpha subunit, middle domain	(Pseudomonas fragi ) [TaxId: 296 ],	SCOPe (2.08)
A	d2d3ta4	Alpha and beta proteins (a/b)	ClpP/crotonase	ClpP/crotonase	Crotonase-like	Fatty oxidation complex alpha subunit, N-terminal domain	(Pseudomonas fragi ) [TaxId: 296 ],	SCOPe (2.08)
B	d2d3tb1	All alpha proteins	6-phosphogluconate dehydrogenase C-terminal domain-like	6-phosphogluconate dehydrogenase C-terminal domain-like	HCDH C-domain-like	Fatty oxidation complex alpha subunit, C-terminal domain	(Pseudomonas fragi ) [TaxId: 296 ],	SCOPe (2.08)
B	d2d3tb3	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	6-phosphogluconate dehydrogenase-like, N-terminal domain	Fatty oxidation complex alpha subunit, middle domain	(Pseudomonas fragi ) [TaxId: 296 ],	SCOPe (2.08)
B	d2d3tb4	Alpha and beta proteins (a/b)	ClpP/crotonase	ClpP/crotonase	Crotonase-like	Fatty oxidation complex alpha subunit, N-terminal domain	(Pseudomonas fragi ) [TaxId: 296 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	Thiolase-like	8041708	3000122	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Thiolase-like	8041706	3000122	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Thiolase-like	8041708	3000122	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Thiolase-like	8041706	3000122	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	6-phosphogluconate dehydrogenase-like	8017508	3000048	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	ClpP/crotonase	8001546	3000033	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	6-phosphogluconate dehydrogenase-like	8017508	3000048	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ClpP/crotonase	8001546	3000033	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	Thiolase_C	e2d3tC1	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: Thiolase_C	ECOD (1.6)
C	Thiolase_N	e2d3tC2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: Thiolase_N	ECOD (1.6)
D	Thiolase_C	e2d3tD1	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: Thiolase_C	ECOD (1.6)
D	Thiolase_N	e2d3tD2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: Thiolase_N	ECOD (1.6)
A	3HCDH	e2d3tA1	A: alpha arrays	X: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)	H: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)	T: 6-phosphogluconate dehydrogenase C-terminal domain-like	F: 3HCDH	ECOD (1.6)
A	3HCDH_N	e2d3tA3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: 3HCDH_N	ECOD (1.6)
A	ECH_1	e2d3tA4	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: ECH_1	ECOD (1.6)
B	3HCDH	e2d3tB1	A: alpha arrays	X: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)	H: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)	T: 6-phosphogluconate dehydrogenase C-terminal domain-like	F: 3HCDH	ECOD (1.6)
B	3HCDH_N	e2d3tB3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: 3HCDH_N	ECOD (1.6)
B	ECH_1	e2d3tB4	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: ECH_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)
D	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)
A	3.90.226.10	Alpha Beta	Alpha-Beta Complex	2-enoyl-CoA Hydratase	Chain A, domain 1	CATH (4.3.0)
A	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
A	1.10.1040.50	Mainly Alpha	Orthogonal Bundle	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase	domain 2	CATH (4.3.0)
B	3.90.226.10	Alpha Beta	Alpha-Beta Complex	2-enoyl-CoA Hydratase	Chain A, domain 1	CATH (4.3.0)
B	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
B	1.10.1040.50	Mainly Alpha	Orthogonal Bundle	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C, D	PF02803	Thiolase, C-terminal domain (Thiolase_C)	Thiolase, C-terminal domain	Thiolase is reported to be structurally related to beta-ketoacyl synthase (Pfam:PF00109), and also chalcone synthase.	Domain
C, D	PF00108	Thiolase, N-terminal domain (Thiolase_N)	Thiolase, N-terminal domain	Thiolase is reported to be structurally related to beta-ketoacyl synthase (Pfam:PF00109), and also chalcone synthase.	Domain
A, B	PF02737	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain (3HCDH_N)	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	This family also includes lambda crystallin.	Domain
A, B	PF00725	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain (3HCDH)	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	This family also includes lambda crystallin. Some proteins include two copies of this domain.	Domain
A, B	PF00378	Enoyl-CoA hydratase/isomerase (ECH_1)	Enoyl-CoA hydratase/isomerase	This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
C, D	3-ketoacyl-CoA thiolase	acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity acetyl-CoA C-acyltransferase activity C-acyltransferase activity catalytic activity	cellular response to stimulus catabolic process response to stimulus oxoacid metabolic process organic acid catabolic process organic acid metabolic process response to xenobiotic stimulus cellular catabolic process monocarboxylic acid catabolic process carboxylic acid catabolic process small molecule metabolic process benzene-containing compound metabolic process cellular response to xenobiotic stimulus carboxylic acid metabolic process cellular response to stimulus catabolic process response to stimulus oxoacid metabolic process organic acid catabolic process organic acid metabolic process response to xenobiotic stimulus cellular catabolic process monocarboxylic acid catabolic process carboxylic acid catabolic process small molecule metabolic process benzene-containing compound metabolic process cellular response to xenobiotic stimulus carboxylic acid metabolic process xenobiotic catabolic process xenobiotic metabolic process cellular response to chemical stimulus response to chemical phenylacetate catabolic process metabolic process cellular process monocarboxylic acid metabolic process small molecule catabolic process fatty acid metabolic process lipid catabolic process primary metabolic process lipid modification fatty acid catabolic process fatty acid oxidation fatty acid beta-oxidation lipid oxidation lipid metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm
A, B	Fatty oxidation complex alpha subunit	NAD+ binding NAD binding binding nucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor NAD+ binding NAD binding binding nucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors 3-hydroxyacyl-CoA dehydrogenase activity catalytic activity isomerase activity intramolecular oxidoreductase activity, transposing C=C bonds intramolecular oxidoreductase activity delta(3)-delta(2)-enoyl-CoA isomerase activity enoyl-CoA hydratase activity hydro-lyase activity lyase activity carbon-oxygen lyase activity racemase and epimerase activity, acting on hydroxy acids and derivatives racemase and epimerase activity 3-hydroxybutyryl-CoA epimerase activity	fatty acid metabolic process lipid catabolic process catabolic process oxoacid metabolic process carboxylic acid metabolic process primary metabolic process lipid modification organic acid catabolic process organic acid metabolic process fatty acid catabolic process cellular catabolic process monocarboxylic acid catabolic process fatty acid oxidation carboxylic acid catabolic process fatty acid beta-oxidation fatty acid metabolic process lipid catabolic process catabolic process oxoacid metabolic process carboxylic acid metabolic process primary metabolic process lipid modification organic acid catabolic process organic acid metabolic process fatty acid catabolic process cellular catabolic process monocarboxylic acid catabolic process fatty acid oxidation carboxylic acid catabolic process fatty acid beta-oxidation metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process lipid oxidation small molecule catabolic process lipid metabolic process	protein-containing complex fatty acid beta-oxidation multienzyme complex catalytic complex oxidoreductase complex transferase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C, D	IPR050215	Thiolase-like superfamily, Thiolase	Family
C, D	IPR002155	Thiolase	Family
C, D	IPR016039	Thiolase-like	Homologous Superfamily
C, D	IPR020617	Thiolase, C-terminal	Domain
C, D	IPR020616	Thiolase, N-terminal	Domain
C, D	IPR020613	Thiolase, conserved site	Conserved Site
C, D	IPR012805	Acetyl-CoA C-acyltransferase FadA	Family
C, D	IPR020610	Thiolase, active site	Active Site
C, D	IPR020615	Thiolase, acyl-enzyme intermediate active site	Active Site
A, B	IPR001753	Enoyl-CoA hydratase/isomerase	Family
A, B	IPR029045	ClpP/crotonase-like domain superfamily	Homologous Superfamily
A, B	IPR050136	Fatty acid oxidation complex subunit alpha	Family
A, B	IPR018376	Enoyl-CoA hydratase/isomerase, conserved site	Conserved Site
A, B	IPR008927	6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily	Homologous Superfamily
A, B	IPR006108	3-hydroxyacyl-CoA dehydrogenase, C-terminal	Domain
A, B	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A, B	IPR006180	3-hydroxyacyl-CoA dehydrogenase, conserved site	Conserved Site
A, B	IPR012799	Fatty oxidation complex, alpha subunit FadB	Family
A, B	IPR006176	3-hydroxyacyl-CoA dehydrogenase, NAD binding	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.