Annotations: 2F86

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth B]	d2f86b1	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	(Caenorhabditis elegans ) [TaxId: 6239 ],	SCOPe (2.08)
B [auth D]	d2f86d_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	automated matches	automated matches	(Caenorhabditis elegans ) [TaxId: 6239 ],	SCOPe (2.08)
C [auth F]	d2f86f_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	automated matches	automated matches	(Caenorhabditis elegans ) [TaxId: 6239 ],	SCOPe (2.08)
D [auth H]	d2f86h_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	automated matches	automated matches	(Caenorhabditis elegans ) [TaxId: 6239 ],	SCOPe (2.08)
E [auth J]	d2f86j_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	automated matches	automated matches	(Caenorhabditis elegans ) [TaxId: 6239 ],	SCOPe (2.08)
F [auth L]	d2f86l_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	automated matches	automated matches	(Caenorhabditis elegans ) [TaxId: 6239 ],	SCOPe (2.08)
G [auth N]	d2f86n_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	automated matches	automated matches	(Caenorhabditis elegans ) [TaxId: 6239 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth B]	SCOP2 Family	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	8021677	4000593	SCOP2 (2022-06-29)
A [auth B]	SCOP2 Superfamily	NTF2-like	8034057	3000472	SCOP2 (2022-06-29)
B [auth D]	SCOP2B Superfamily	NTF2-like	8034057	3000472	SCOP2B (2022-06-29)
C [auth F]	SCOP2B Superfamily	NTF2-like	8034057	3000472	SCOP2B (2022-06-29)
D [auth H]	SCOP2B Superfamily	NTF2-like	8034057	3000472	SCOP2B (2022-06-29)
E [auth J]	SCOP2B Superfamily	NTF2-like	8034057	3000472	SCOP2B (2022-06-29)
F [auth L]	SCOP2B Superfamily	NTF2-like	8034057	3000472	SCOP2B (2022-06-29)
G [auth N]	SCOP2B Superfamily	NTF2-like	8034057	3000472	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	DUF4440	e2f86B1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
B [auth D]	DUF4440	e2f86D1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
C [auth F]	DUF4440	e2f86F1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
D [auth H]	DUF4440	e2f86H1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
E [auth J]	DUF4440	e2f86J1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
F [auth L]	DUF4440	e2f86L1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
G [auth N]	DUF4440	e2f86N1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth B]	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
B [auth D]	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
C [auth F]	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
D [auth H]	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
E [auth J]	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
F [auth L]	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
G [auth N]	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth D], C [auth F], D [auth H], E [auth J], A [auth B], B [auth D], C [auth F], D [auth H], E [auth J], F [auth L], G [auth N]	PF08332	Calcium/calmodulin dependent protein kinase II association domain (CaMKII_AD)	Calcium/calmodulin dependent protein kinase II association domain	This domain is found at the C-terminus of the Calcium/calmodulin dependent protein kinases II (CaMKII). These proteins also have a Ser/Thr protein kinase domain (Pfam:PF00069) at their N-terminus [1]. The function of the CaMKII association domain i ...	This domain is found at the C-terminus of the Calcium/calmodulin dependent protein kinases II (CaMKII). These proteins also have a Ser/Thr protein kinase domain (Pfam:PF00069) at their N-terminus [1]. The function of the CaMKII association domain is the assembly of the single proteins into large (8 to 14 subunits) multimers [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth D], C [auth F], D [auth H], E [auth J], A [auth B], B [auth D], C [auth F], D [auth H], E [auth J], F [auth L], G [auth N]	Hypothetical protein K11E8.1d	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein binding transmembrane transporter binding protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity calcium/calmodulin-dependent protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups calmodulin binding cation binding metal ion binding protein serine kinase activity identical protein binding	behavior multicellular organismal process system process learning or memory nervous system process medium-term memory cognition memory serotonin metabolic process organic hydroxy compound metabolic process indole-containing compound metabolic process primary amino compound biosynthetic process primary amino compound metabolic process ammonium ion metabolic process behavior multicellular organismal process system process learning or memory nervous system process medium-term memory cognition memory serotonin metabolic process organic hydroxy compound metabolic process indole-containing compound metabolic process primary amino compound biosynthetic process primary amino compound metabolic process ammonium ion metabolic process biosynthetic process indole-containing compound biosynthetic process phenol-containing compound metabolic process organic hydroxy compound biosynthetic process phenol-containing compound biosynthetic process metabolic process cellular process serotonin biosynthetic process protein phosphorylation phosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process regulation of biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process regulation of metabolic process positive regulation of cellular process cellular response to stimulus response to stimulus signaling intracellular signal transduction cell communication intracellular signaling cassette MAPK cascade signal transduction	somatodendritic compartment cell body cellular anatomical structure perikaryon neuronal cell body intracellular anatomical structure cytoplasm neuron projection cytoplasm axon axon cytoplasm neuron projection cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection somatodendritic compartment cell body cellular anatomical structure perikaryon neuronal cell body intracellular anatomical structure cytoplasm neuron projection cytoplasm axon axon cytoplasm neuron projection cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection cell projection

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth D], C [auth F], D [auth H], E [auth J], A [auth B], B [auth D], C [auth F], D [auth H], E [auth J], F [auth L], G [auth N]	IPR032710	NTF2-like domain superfamily	Homologous Superfamily
A [auth B], B [auth D], C [auth F], D [auth H], E [auth J], A [auth B], B [auth D], C [auth F], D [auth H], E [auth J], F [auth L], G [auth N]	IPR017441	Protein kinase, ATP binding site	Binding Site
A [auth B], B [auth D], C [auth F], D [auth H], E [auth J], A [auth B], B [auth D], C [auth F], D [auth H], E [auth J], F [auth L], G [auth N]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A [auth B], B [auth D], C [auth F], D [auth H], E [auth J], A [auth B], B [auth D], C [auth F], D [auth H], E [auth J], F [auth L], G [auth N]	IPR013543	Calcium/calmodulin-dependent protein kinase II, association-domain	Domain
A [auth B], B [auth D], C [auth F], D [auth H], E [auth J], A [auth B], B [auth D], C [auth F], D [auth H], E [auth J], F [auth L], G [auth N]	IPR000719	Protein kinase domain	Domain
A [auth B], B [auth D], C [auth F], D [auth H], E [auth J], A [auth B], B [auth D], C [auth F], D [auth H], E [auth J], F [auth L], G [auth N]	IPR008271	Serine/threonine-protein kinase, active site	Active Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.