2H1S
Crystal Structure of a Glyoxylate/Hydroxypyruvate reductase from Homo sapiens
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
D | SCOP2B Superfamily | D-2-hydroxyacid dehydrogenase-like | 8079260 | 3000044 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | D-2-hydroxyacid dehydrogenase-like | 8079260 | 3000044 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | D-2-hydroxyacid dehydrogenase-like | 8079260 | 3000044 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | D-2-hydroxyacid dehydrogenase-like | 8079260 | 3000044 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
D | 2-Hacid_dh_C | e2h1sD1 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: NAD(P)-binding Rossmann-fold domains | F: 2-Hacid_dh_C | ECOD (1.6) |
D | 2-Hacid_dh | e2h1sD2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: Formate/glycerate dehydrogenase catalytic domain-like | F: 2-Hacid_dh | ECOD (1.6) |
A | 2-Hacid_dh_C | e2h1sA1 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: NAD(P)-binding Rossmann-fold domains | F: 2-Hacid_dh_C | ECOD (1.6) |
A | 2-Hacid_dh | e2h1sA2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: Formate/glycerate dehydrogenase catalytic domain-like | F: 2-Hacid_dh | ECOD (1.6) |
B | 2-Hacid_dh_C | e2h1sB1 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: NAD(P)-binding Rossmann-fold domains | F: 2-Hacid_dh_C | ECOD (1.6) |
B | 2-Hacid_dh | e2h1sB2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: Formate/glycerate dehydrogenase catalytic domain-like | F: 2-Hacid_dh | ECOD (1.6) |
C | 2-Hacid_dh_C | e2h1sC1 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: NAD(P)-binding Rossmann-fold domains | F: 2-Hacid_dh_C | ECOD (1.6) |
C | 2-Hacid_dh | e2h1sC2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: Formate/glycerate dehydrogenase catalytic domain-like | F: 2-Hacid_dh | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
D | 3.40.50.720 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | NAD(P)-binding Rossmann-like Domain | CATH (4.3.0) |
A | 3.40.50.720 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | NAD(P)-binding Rossmann-like Domain | CATH (4.3.0) |
B | 3.40.50.720 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | NAD(P)-binding Rossmann-like Domain | CATH (4.3.0) |
C | 3.40.50.720 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | NAD(P)-binding Rossmann-like Domain | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF02826 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain (2-Hacid_dh_C) | D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain | This domain is inserted into the catalytic domain, the large dehydrogenase and D-lactate dehydrogenase families in SCOP. N-terminal portion of which is represented by family Pfam:PF00389. | Domain | |
PF00389 | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain (2-Hacid_dh) | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain | This family represents the largest portion of the catalytic domain of 2-hydroxyacid dehydrogenases as the NAD binding domain is inserted within the structural domain. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Pharos: Disease Associations Pharos Homepage Annotation
Chains | Drug Target   | Associated Disease |
---|---|---|
Q9UBQ7 | :