2H62 | pdb_00002h62

Crystal structure of a ternary ligand-receptor complex of BMP-2

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2h62a_	Small proteins	Cystine-knot cytokines	Cystine-knot cytokines	Transforming growth factor (TGF)-beta	Bone morphogenetic protein-2 (BMP-2)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2h62b_	Small proteins	Cystine-knot cytokines	Cystine-knot cytokines	Transforming growth factor (TGF)-beta	Bone morphogenetic protein-2 (BMP-2)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d2h62c_	Small proteins	Snake toxin-like	Snake toxin-like	Extracellular domain of cell surface receptors	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d2h62d_	Small proteins	Snake toxin-like	Snake toxin-like	Extracellular domain of cell surface receptors	BMP receptor Ia ectodomain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Transforming growth factor (TGF)-beta	8029785	4003433	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Cystine-knot cytokines	8042164	3000846	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Cystine-knot cytokines	8042164	3000846	SCOP2B (2022-06-29)
C	SCOP2 Family	Extracellular domain of cell surface receptors	8029788	4003329	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	Snake toxin-like	8042167	3000545	SCOP2 (2022-06-29)
D	SCOP2 Family	Extracellular domain of cell surface receptors	8029787	4003329	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	Snake toxin-like	8042166	3000545	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	TGF_beta	e2h62A1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: TGF_beta	ECOD (1.6)
B	TGF_beta	e2h62B1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: TGF_beta	ECOD (1.6)
C	Activin_recp	e2h62C1	A: few secondary structure elements	X: Snake toxin-like (From Topology)	H: Snake toxin-like (From Topology)	T: Snake toxin-like	F: Activin_recp	ECOD (1.6)
D	Activin_recp	e2h62D1	A: few secondary structure elements	X: Snake toxin-like (From Topology)	H: Snake toxin-like (From Topology)	T: Snake toxin-like	F: Activin_recp	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.10.90.10	Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines	CATH (4.3.0)
B	2.10.90.10	Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines	CATH (4.3.0)
C	2.10.60.10	Mainly Beta	Ribbon	CD59	CD59	CATH (4.3.0)
D	2.10.60.10	Mainly Beta	Ribbon	CD59	CD59	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00019	Transforming growth factor beta like domain (TGF_beta)	Transforming growth factor beta like domain		Domain
C	PF01064	Activin types I and II receptor domain (Activin_recp)	Activin types I and II receptor domain	This Pfam entry consists of both TGF-beta receptor types. This is an alignment of the hydrophilic cysteine-rich ligand-binding domains, Both receptor types, (type I and II) posses a 9 amino acid cysteine box, with the the consensus CCX{4-5}CN. The t ...	This Pfam entry consists of both TGF-beta receptor types. This is an alignment of the hydrophilic cysteine-rich ligand-binding domains, Both receptor types, (type I and II) posses a 9 amino acid cysteine box, with the the consensus CCX{4-5}CN. The type I receptors also possess 7 extracellular residues preceding the cysteine box.	Domain
D	PF01064	Activin types I and II receptor domain (Activin_recp)	Activin types I and II receptor domain	This Pfam entry consists of both TGF-beta receptor types. This is an alignment of the hydrophilic cysteine-rich ligand-binding domains, Both receptor types, (type I and II) posses a 9 amino acid cysteine box, with the the consensus CCX{4-5}CN. The t ...	This Pfam entry consists of both TGF-beta receptor types. This is an alignment of the hydrophilic cysteine-rich ligand-binding domains, Both receptor types, (type I and II) posses a 9 amino acid cysteine box, with the the consensus CCX{4-5}CN. The type I receptors also possess 7 extracellular residues preceding the cysteine box.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Bone morphogenetic protein 2	phosphoric ester hydrolase activity enzyme regulator activity phosphatase activator activity molecular function activator activity phosphatase regulator activity phosphatase activity hydrolase activity enzyme activator activity hydrolase activity, acting on ester bonds molecular function regulator activity catalytic activity protein serine/threonine kinase activity protein serine/threonine kinase activator activity catalytic activity, acting on a protein phosphoric ester hydrolase activity enzyme regulator activity phosphatase activator activity molecular function activator activity phosphatase regulator activity phosphatase activity hydrolase activity enzyme activator activity hydrolase activity, acting on ester bonds molecular function regulator activity catalytic activity protein serine/threonine kinase activity protein serine/threonine kinase activator activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity protein kinase regulator activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups kinase activator activity protein kinase activator activity kinase regulator activity protein binding binding signaling receptor binding BMP receptor binding receptor serine/threonine kinase binding transmembrane receptor protein serine/threonine kinase binding co-receptor binding molecular transducer activity signaling receptor activity growth factor activity signaling receptor activator activity signaling receptor regulator activity receptor ligand activity cytokine activity	cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction enzyme-linked receptor protein signaling pathway positive regulation of cellular process regulation of biological process regulation of signaling cell surface receptor signaling pathway biological regulation positive regulation of intracellular signal transduction positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway SMAD protein signal transduction regulation of response to stimulus regulation of cell communication cellular process regulation of SMAD protein signal transduction positive regulation of SMAD protein signal transduction positive regulation of signaling developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development ossification bone mineralization biomineral tissue development tissue development regulation of developmental process cellular developmental process negative regulation of biological process negative regulation of muscle cell differentiation regulation of cell differentiation regulation of striated muscle cell differentiation regulation of cardiac muscle cell differentiation muscle cell differentiation striated muscle tissue development muscle structure development cell differentiation negative regulation of cardiac muscle cell differentiation negative regulation of cellular process negative regulation of cell differentiation regulation of multicellular organismal process muscle tissue development negative regulation of cardiocyte differentiation cardiac muscle tissue development negative regulation of developmental process negative regulation of striated muscle cell differentiation cardiac muscle cell differentiation cardiocyte differentiation regulation of muscle cell differentiation regulation of cardiocyte differentiation striated muscle cell differentiation negative regulation of multicellular organismal process regulation of animal organ morphogenesis regulation of odontogenesis odontogenesis positive regulation of odontogenesis positive regulation of developmental process anatomical structure morphogenesis positive regulation of animal organ morphogenesis positive regulation of multicellular organismal process animal organ morphogenesis regulation of anatomical structure morphogenesis corticotropin hormone secreting cell differentiation head development forebrain development endocrine system development pituitary gland development gland development brain development diencephalon development nervous system development central nervous system development adenohypophysis development regulation of localization regulation of cellular component organization positive regulation of cellular component organization transport positive regulation of extracellular matrix constituent secretion positive regulation of extracellular matrix organization extracellular matrix organization positive regulation of secretion by cell cellular component organization localization regulation of secretion by cell secretion by cell positive regulation of secretion cellular component organization or biogenesis regulation of extracellular matrix constituent secretion extracellular structure organization regulation of transport secretion export from cell establishment of localization regulation of secretion positive regulation of transport extracellular matrix constituent secretion regulation of extracellular matrix organization external encapsulating structure organization regulation of biomineral tissue development regulation of bone mineralization positive regulation of ossification positive regulation of biomineral tissue development regulation of multicellular organismal development positive regulation of bone mineralization regulation of ossification mesenchyme morphogenesis endocardial cushion morphogenesis heart morphogenesis mesenchyme development endocardial cushion formation tissue morphogenesis endocardial cushion development anatomical structure formation involved in morphogenesis positive regulation of DNA-templated transcription RNA metabolic process positive regulation of miRNA transcription positive regulation of miRNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process positive regulation of metabolic process regulation of RNA metabolic process miRNA transcription positive regulation of biosynthetic process regulation of miRNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process miRNA metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process regulation of miRNA transcription intracellular receptor signaling pathway positive regulation of peroxisome proliferator activated receptor signaling pathway peroxisome proliferator activated receptor signaling pathway regulation of peroxisome proliferator activated receptor signaling pathway nuclear receptor-mediated signaling pathway cell population proliferation positive regulation of cell population proliferation positive regulation of osteoblast proliferation osteoblast proliferation regulation of cell population proliferation regulation of osteoblast proliferation cell fate commitment anterior/posterior pattern specification pattern specification process regionalization embryonic heart tube anterior/posterior pattern specification connective tissue development skeletal system development chondrocyte differentiation cartilage development negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process Notch signaling pathway carbohydrate derivative metabolic process protein metabolic process proteoglycan metabolic process glycoprotein metabolic process fat cell differentiation negative regulation of fat cell differentiation regulation of fat cell differentiation epithelium development pericardium development positive regulation of ERK1 and ERK2 cascade positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade muscle tissue morphogenesis cardiac muscle tissue morphogenesis muscle organ development muscle organ morphogenesis endodermal-mesodermal cell signaling cell-cell signaling regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition positive regulation of cell differentiation epithelial to mesenchymal transition mesenchymal cell differentiation negative regulation of small molecule metabolic process regulation of hormone biosynthetic process regulation of lipid metabolic process negative regulation of lipid biosynthetic process negative regulation of hormone biosynthetic process regulation of small molecule metabolic process negative regulation of aldosterone biosynthetic process negative regulation of aldosterone metabolic process small molecule metabolic process regulation of biological quality primary alcohol biosynthetic process hormone biosynthetic process negative regulation of steroid hormone biosynthetic process regulation of steroid hormone biosynthetic process negative regulation of steroid metabolic process regulation of alcohol biosynthetic process olefinic compound biosynthetic process regulation of hormone levels C21-steroid hormone biosynthetic process regulation of ketone metabolic process negative regulation of alcohol biosynthetic process regulation of aldosterone biosynthetic process negative regulation of hormone metabolic process negative regulation of lipid metabolic process regulation of steroid biosynthetic process mineralocorticoid biosynthetic process regulation of hormone metabolic process ketone metabolic process steroid metabolic process lipid biosynthetic process alcohol metabolic process C21-steroid hormone metabolic process aldehyde biosynthetic process mineralocorticoid metabolic process aldosterone metabolic process steroid biosynthetic process steroid hormone biosynthetic process small molecule biosynthetic process aldosterone biosynthetic process regulation of ketone biosynthetic process regulation of steroid metabolic process hormone metabolic process aldehyde metabolic process regulation of aldosterone metabolic process alcohol biosynthetic process negative regulation of steroid biosynthetic process olefinic compound metabolic process regulation of lipid biosynthetic process ketone biosynthetic process lipid metabolic process primary alcohol metabolic process cardiac atrium formation cardiac chamber morphogenesis cardiac atrium morphogenesis cardiac chamber formation cardiac atrium development cardiac chamber development thyroid-stimulating hormone-secreting cell differentiation epithelial cell differentiation neurogenesis neuron differentiation neuroepithelial cell differentiation neuroendocrine cell differentiation generation of neurons glandular epithelial cell differentiation columnar/cuboidal epithelial cell differentiation telencephalon regionalization forebrain regionalization telencephalon development regulation of phosphatase activity regulation of catalytic activity positive regulation of phosphate metabolic process positive regulation of molecular function regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of phosphatase activity phosphorus metabolic process positive regulation of phosphorus metabolic process positive regulation of dephosphorylation regulation of dephosphorylation dephosphorylation positive regulation of catalytic activity regulation of molecular function positive regulation of hydrolase activity regulation of hydrolase activity regulation of phosphorus metabolic process positive regulation of odontoblast differentiation regulation of epithelial cell differentiation odontoblast differentiation regulation of odontoblast differentiation positive regulation of epithelial cell differentiation positive regulation of neuroepithelial cell differentiation positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion p38MAPK cascade positive regulation of p38MAPK cascade regulation of p38MAPK cascade myeloid leukocyte differentiation hemopoiesis cell development myeloid cell differentiation osteoclast differentiation leukocyte differentiation defense response response to stress inflammatory response cortisol metabolic process tertiary alcohol metabolic process glucocorticoid metabolic process glucocorticoid biosynthetic process regulation of cortisol biosynthetic process negative regulation of cortisol biosynthetic process regulation of glucocorticoid metabolic process regulation of glucocorticoid biosynthetic process negative regulation of glucocorticoid biosynthetic process negative regulation of glucocorticoid metabolic process cortisol biosynthetic process tertiary alcohol biosynthetic process negative regulation of gene expression ameloblast differentiation positive regulation of nervous system development astrocyte differentiation regulation of neurogenesis regulation of gliogenesis regulation of astrocyte differentiation positive regulation of gliogenesis regulation of cell development regulation of nervous system development gliogenesis positive regulation of neurogenesis positive regulation of astrocyte differentiation positive regulation of cell development regulation of glial cell differentiation positive regulation of glial cell differentiation glial cell differentiation cellular response to BMP stimulus cellular response to endogenous stimulus response to BMP cellular response to growth factor stimulus response to endogenous stimulus response to growth factor protein destabilization regulation of protein stability positive regulation of gene expression ear development sensory organ development inner ear development bone development negative regulation of signaling regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway negative regulation of cell communication negative regulation of Wnt signaling pathway Wnt signaling pathway regulation of Wnt signaling pathway negative regulation of response to stimulus negative regulation of signal transduction negative regulation of canonical Wnt signaling pathway negative regulation of cell cycle cell cycle regulation of cell cycle positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death ureteric bud development mesonephric epithelium development kidney epithelium development mesenchymal cell proliferation involved in ureteric bud development mesonephros development tube development cell proliferation involved in kidney development renal system development mesenchymal cell proliferation cell proliferation involved in mesonephros development kidney development mesonephric tubule development embryo development ending in birth or egg hatching chordate embryonic development embryo development in utero embryonic development regulation of calcium-independent cell-cell adhesion regulation of cell adhesion negative regulation of cell adhesion cell adhesion cell-cell adhesion negative regulation of cell-cell adhesion calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules regulation of cell-cell adhesion negative regulation of calcium-independent cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules negative regulation of transforming growth factor beta receptor signaling pathway cellular response to transforming growth factor beta stimulus regulation of transforming growth factor beta receptor signaling pathway regulation of cellular response to transforming growth factor beta stimulus regulation of cellular response to growth factor stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway transforming growth factor beta receptor superfamily signaling pathway negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of Wnt signaling pathway cardiac epithelial to mesenchymal transition response to decreased oxygen levels response to hypoxia response to oxygen levels response to abiotic stimulus positive regulation of fat cell differentiation nephron morphogenesis branching morphogenesis of an epithelial tube nephron tubule morphogenesis nephron epithelium morphogenesis nephron tubule development ureteric bud morphogenesis tube morphogenesis branching involved in ureteric bud morphogenesis renal tubule development epithelial tube morphogenesis nephron development nephron epithelium development morphogenesis of an epithelium kidney morphogenesis morphogenesis of a branching structure mesonephric tubule morphogenesis renal tubule morphogenesis morphogenesis of a branching epithelium cardiac jelly development positive regulation of transcription by RNA polymerase II heart induction specification of animal organ identity developmental induction animal organ formation heart formation regulation of animal organ formation organ induction regulation of heart morphogenesis heart field specification regulation of odontogenesis of dentin-containing tooth odontogenesis of dentin-containing tooth regulation of cartilage development positive regulation of cartilage development osteoblast differentiation BMP signaling pathway negative regulation of cell population proliferation regulation of smooth muscle cell proliferation smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation muscle cell proliferation bone maturation regulation of bone mineralization involved in bone maturation positive regulation of bone mineralization involved in bone maturation ossification involved in bone maturation bone mineralization involved in bone maturation developmental maturation anatomical structure maturation animal organ maturation positive regulation of neuron differentiation regulation of neuron differentiation regulation of osteoblast differentiation positive regulation of osteoblast differentiation biological process involved in interspecies interaction between organisms response to other organism response to bacterium response to external stimulus response to external biotic stimulus response to biotic stimulus cell surface receptor protein tyrosine kinase signaling pathway regulation of insulin-like growth factor receptor signaling pathway insulin-like growth factor receptor signaling pathway negative regulation of insulin-like growth factor receptor signaling pathway positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of protein modification process positive regulation of protein phosphorylation protein modification process protein phosphorylation phosphorylation regulation of protein metabolic process macromolecule modification regulation of phosphorylation heart valve development aortic valve development semi-lunar valve development atrioventricular canal morphogenesis atrioventricular canal development respiratory tube development vasculature development lung vasculature development lung development respiratory system development atrioventricular valve development heart valve morphogenesis atrioventricular valve morphogenesis	cell periphery protein-containing complex cellular anatomical structure plasma membrane protein complex membrane plasma membrane plasma membrane signaling receptor complex membrane protein complex BMP receptor complex receptor complex extracellular region extracellular space cell surface membrane-bounded organelle cell periphery protein-containing complex cellular anatomical structure plasma membrane protein complex membrane plasma membrane plasma membrane signaling receptor complex membrane protein complex BMP receptor complex receptor complex extracellular region extracellular space cell surface membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle
C	Bone morphogenetic protein receptor type IA	protein serine/threonine kinase activity molecular transducer activity catalytic activity, acting on a protein kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta receptor activity, type II transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity protein serine/threonine kinase activity molecular transducer activity catalytic activity, acting on a protein kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta receptor activity, type II transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity transforming growth factor beta receptor activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding transforming growth factor beta receptor activity, type III cation binding metal ion binding activin receptor activity activin receptor activity, type II identical protein binding protein binding protein homodimerization activity protein dimerization activity SMAD binding transforming growth factor beta receptor activity, type I activin receptor activity, type I BMP binding cytokine binding BMP receptor activity	cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction enzyme-linked receptor protein signaling pathway positive regulation of cellular process regulation of biological process regulation of signaling cell surface receptor signaling pathway biological regulation positive regulation of intracellular signal transduction positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway SMAD protein signal transduction regulation of response to stimulus regulation of cell communication cellular process regulation of SMAD protein signal transduction positive regulation of SMAD protein signal transduction positive regulation of signaling developmental process multicellular organism development multicellular organismal process dorsal/ventral pattern formation dorsal/ventral axis specification anatomical structure development pattern specification process axis specification regionalization heart development cardiac chamber morphogenesis animal organ development heart morphogenesis ventricular septum development circulatory system development anatomical structure morphogenesis cardiac septum development cardiac septum morphogenesis ventricular septum morphogenesis cardiac chamber development animal organ morphogenesis cardiac ventricle development system development reproductive process sex differentiation developmental process involved in reproduction anatomical structure regression male sex differentiation Mullerian duct regression regulation of developmental process regulation of biomineral tissue development regulation of bone mineralization positive regulation of ossification positive regulation of developmental process positive regulation of biomineral tissue development ossification biomineral tissue development regulation of multicellular organismal process regulation of multicellular organismal development bone mineralization tissue development positive regulation of bone mineralization positive regulation of multicellular organismal process regulation of ossification mesenchyme morphogenesis endocardial cushion morphogenesis mesenchyme development endocardial cushion formation tissue morphogenesis endocardial cushion development anatomical structure formation involved in morphogenesis positive regulation of DNA-templated transcription RNA metabolic process positive regulation of miRNA transcription positive regulation of miRNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process positive regulation of metabolic process regulation of RNA metabolic process miRNA transcription positive regulation of biosynthetic process regulation of miRNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process miRNA metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process regulation of miRNA transcription outflow tract septum morphogenesis outflow tract morphogenesis somatic stem cell population maintenance maintenance of cell number stem cell population maintenance cellular developmental process negative regulation of biological process cell development regulation of cell differentiation regulation of neurogenesis regulation of cell development regulation of nervous system development negative regulation of neurogenesis neurogenesis cell differentiation negative regulation of cellular process negative regulation of nervous system development negative regulation of cell differentiation negative regulation of developmental process nervous system development negative regulation of cell development negative regulation of multicellular organismal process connective tissue development skeletal system development chondrocyte differentiation cartilage development blood vessel morphogenesis tube development chordate embryonic development artery development pharyngeal arch artery morphogenesis embryo development vasculature development tube morphogenesis embryo development ending in birth or egg hatching pharyngeal system development artery morphogenesis blood vessel development cardiac right ventricle morphogenesis cardiac ventricle morphogenesis cellular response to growth factor stimulus cellular response to transforming growth factor beta stimulus response to endogenous stimulus cellular response to endogenous stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway ventricular cardiac muscle tissue morphogenesis striated muscle tissue development muscle structure development ventricular cardiac muscle tissue development ventricular trabecula myocardium morphogenesis muscle tissue development muscle organ development cardiac muscle tissue development muscle tissue morphogenesis cardiac muscle tissue morphogenesis heart trabecula morphogenesis trabecula morphogenesis muscle organ morphogenesis heart formation animal organ formation atrioventricular valve development heart valve development immune response immune system process somitogenesis epithelium development segmentation anterior/posterior pattern specification somite development generation of neurons central nervous system neuron differentiation central nervous system development neuron differentiation positive regulation of mesenchymal cell proliferation cell population proliferation positive regulation of cell population proliferation regulation of mesenchymal cell proliferation regulation of cell population proliferation mesenchymal cell proliferation epithelial cell proliferation regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization cell projection organization neuron projection development cellular component organization dendrite development positive regulation of neuron projection development positive regulation of cell projection organization cellular component organization or biogenesis plasma membrane bounded cell projection organization regulation of cell projection organization positive regulation of dendrite development regulation of dendrite development neuron development regulation of plasma membrane bounded cell projection organization fibrous ring of heart morphogenesis endoderm development mesendoderm development mesoderm development negative regulation of metabolic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process regulation of growth regulation of cardiac muscle tissue growth developmental growth cardiac muscle cell proliferation organ growth regulation of organ growth regulation of heart growth regulation of cardiac muscle cell proliferation muscle cell proliferation cardiac muscle tissue growth striated muscle cell proliferation heart growth regulation of developmental growth growth aorta morphogenesis aorta development dorsal aorta morphogenesis dorsal aorta development limb development appendage development embryonic limb morphogenesis embryonic morphogenesis embryonic appendage morphogenesis appendage morphogenesis embryonic digit morphogenesis limb morphogenesis cellular response to BMP stimulus response to BMP ectoderm development regulation of cellular senescence cellular response to stress response to stress cellular senescence negative regulation of locomotion regulation of cell motility regulation of smooth muscle cell migration smooth muscle cell migration muscle cell migration negative regulation of smooth muscle cell migration regulation of locomotion regulation of cell migration negative regulation of cell motility cell migration cell motility locomotion negative regulation of cell migration positive regulation of gene expression positive regulation of cardiac muscle cell proliferation positive regulation of developmental growth positive regulation of heart growth positive regulation of organ growth positive regulation of growth positive regulation of cardiac muscle tissue growth negative regulation of muscle cell differentiation muscle cell differentiation regulation of muscle cell differentiation regulation of transforming growth factor beta production regulation of transforming growth factor beta2 production positive regulation of transforming growth factor beta2 production cytokine production regulation of cytokine production transforming growth factor beta production transforming growth factor beta2 production positive regulation of transforming growth factor beta production positive regulation of cytokine production head development forebrain development endocrine system development pituitary gland development gland development brain development diencephalon development in utero embryonic development embryonic organ development lateral mesoderm development mesodermal cell differentiation lateral mesodermal cell fate specification mesoderm morphogenesis lateral mesoderm morphogenesis regulation of mesodermal cell fate specification regulation of lateral mesodermal cell fate specification regulation of mesodermal cell differentiation mesodermal cell fate commitment lateral mesoderm formation mesoderm formation regulation of anatomical structure morphogenesis mesodermal cell fate specification formation of primary germ layer regulation of animal organ morphogenesis regulation of cell fate commitment cell fate specification lateral mesodermal cell differentiation gastrulation cell fate commitment involved in formation of primary germ layer regulation of cell fate specification lateral mesodermal cell fate commitment cell fate commitment cardiac muscle cell development cardiac pacemaker cell development striated muscle cell development muscle cell development atrioventricular node development atrioventricular node cell development cardiac cell development cardiac conduction system development atrioventricular node cell differentiation cardiac muscle cell differentiation cardiocyte differentiation striated muscle cell differentiation cardiac pacemaker cell differentiation cardiac septum cell differentiation mitral valve morphogenesis heart valve morphogenesis mitral valve development atrioventricular valve morphogenesis transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II neural plate pattern specification neural plate regionalization neural plate mediolateral regionalization osteoblast differentiation BMP signaling pathway angiogenesis odontogenesis of dentin-containing tooth odontogenesis respiratory tube development lung development respiratory system development paraxial mesoderm structural organization mesoderm structural organization paraxial mesoderm development anatomical structure arrangement paraxial mesoderm morphogenesis regulation of vascular associated smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell proliferation regulation of smooth muscle cell proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation vascular associated smooth muscle cell proliferation positive regulation of epithelial cell proliferation regulation of epithelial cell proliferation tricuspid valve development tricuspid valve morphogenesis regulation of osteoblast differentiation positive regulation of osteoblast differentiation positive regulation of cell differentiation stem cell development neural crest cell differentiation neural crest cell development stem cell differentiation mesenchymal cell differentiation positive regulation of cardiac ventricle development regulation of cardiac ventricle development ventricular compact myocardium morphogenesis hindlimb morphogenesis roof of mouth development	protein-containing complex receptor complex cell periphery cellular anatomical structure plasma membrane membrane cell surface external side of plasma membrane side of membrane plasma membrane protein complex plasma membrane signaling receptor complex membrane protein complex HFE-transferrin receptor complex somatodendritic compartment protein-containing complex receptor complex cell periphery cellular anatomical structure plasma membrane membrane cell surface external side of plasma membrane side of membrane plasma membrane protein complex plasma membrane signaling receptor complex membrane protein complex HFE-transferrin receptor complex somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection cell body neuronal cell body
D	Acvr2b protein	protein serine/threonine kinase activity molecular transducer activity catalytic activity, acting on a protein kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta receptor activity, type II transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity protein serine/threonine kinase activity molecular transducer activity catalytic activity, acting on a protein kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta receptor activity, type II transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity transforming growth factor beta receptor activity protein-containing complex binding activin binding binding enzyme regulator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity kinase regulator activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding transforming growth factor beta receptor activity, type III activin receptor activity cation binding metal ion binding activin receptor activity, type II protein serine/threonine/tyrosine kinase activity protein binding growth factor binding BMP receptor activity transforming growth factor beta receptor activity, type I activin receptor activity, type I	developmental process multicellular organism development multicellular organismal process anatomical structure development pattern specification process heart development animal organ development circulatory system development system development epithelium development endothelial cell differentiation cellular developmental process endothelium development lymphatic endothelial cell differentiation developmental process multicellular organism development multicellular organismal process anatomical structure development pattern specification process heart development animal organ development circulatory system development system development epithelium development endothelial cell differentiation cellular developmental process endothelium development lymphatic endothelial cell differentiation tissue development epithelial cell differentiation vasculature development cell differentiation cellular process lymph vessel development digestive system development foregut morphogenesis tube development embryonic morphogenesis embryo development digestive tract development anatomical structure morphogenesis tube morphogenesis embryonic foregut morphogenesis digestive tract morphogenesis mesoderm development artery development blood vessel development regulation of developmental process positive regulation of biological process regulation of biomineral tissue development regulation of bone mineralization positive regulation of ossification positive regulation of developmental process positive regulation of biomineral tissue development ossification biomineral tissue development regulation of multicellular organismal process regulation of multicellular organismal development regulation of biological process bone mineralization biological regulation positive regulation of bone mineralization positive regulation of multicellular organismal process regulation of ossification regulation of cellular process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process skeletal system development skeletal system morphogenesis animal organ morphogenesis cellular response to stimulus cell surface receptor protein serine/threonine kinase signaling pathway cell surface receptor signaling pathway response to stimulus signaling cell communication signal transduction enzyme-linked receptor protein signaling pathway negative regulation of biological process negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process kidney development renal system development protein localization establishment of protein localization cellular localization nitrogen compound transport transport hormone secretion protein localization to extracellular region peptide secretion localization secretion by cell amide transport signal release cellular macromolecule localization regulation of biological quality secretion regulation of hormone levels establishment of protein localization to extracellular region cell-cell signaling export from cell protein secretion establishment of localization peptide transport protein transport peptide hormone secretion macromolecule localization hormone transport insulin secretion positive regulation of activin receptor signaling pathway positive regulation of cell communication activin receptor signaling pathway positive regulation of signal transduction regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of signal transduction positive regulation of response to stimulus positive regulation of cellular process regulation of signaling positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of response to stimulus regulation of cell communication transforming growth factor beta receptor superfamily signaling pathway regulation of activin receptor signaling pathway positive regulation of signaling sensory organ development retina vasculature development in camera-type eye eye development retina development in camera-type eye visual system development camera-type eye development sensory system development cellular response to BMP stimulus cellular response to growth factor stimulus response to endogenous stimulus cellular response to endogenous stimulus response to BMP response to growth factor BMP signaling pathway gastrulation with mouth forming second gastrulation developmental growth growth organ growth odontogenesis of dentin-containing tooth odontogenesis lymphangiogenesis anatomical structure formation involved in morphogenesis lymph vessel morphogenesis respiratory tube development lung development respiratory system development response to hexose response to monosaccharide response to carbohydrate response to glucose response to chemical response to oxygen-containing compound determination of bilateral symmetry determination of left/right symmetry left/right pattern formation regionalization specification of symmetry pancreas development blood vessel remodeling tissue remodeling regulation of osteoblast differentiation regulation of cell differentiation osteoblast differentiation positive regulation of osteoblast differentiation positive regulation of cell differentiation venous blood vessel development negative regulation of cold-induced thermogenesis homeostatic process adaptive thermogenesis multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis negative regulation of multicellular organismal process negative regulation of ossification post-embryonic development anterior/posterior pattern specification roof of mouth development	cellular anatomical structure intracellular anatomical structure cytoplasm protein-containing complex receptor complex catalytic complex plasma membrane protein complex membrane plasma membrane membrane protein complex transferase complex protein kinase complex transferase complex, transferring phosphorus-containing groups cell periphery cellular anatomical structure intracellular anatomical structure cytoplasm protein-containing complex receptor complex catalytic complex plasma membrane protein complex membrane plasma membrane membrane protein complex transferase complex protein kinase complex transferase complex, transferring phosphorus-containing groups cell periphery serine/threonine protein kinase complex plasma membrane signaling receptor complex activin receptor complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR029034	Cystine-knot cytokine	Homologous Superfamily
A, B	IPR047953	Bone morphogenetic protein 2, TGF-beta-like domain	Domain
A, B	IPR017948	Transforming growth factor beta, conserved site	Conserved Site
A, B	IPR001839	Transforming growth factor-beta, C-terminal	Domain
A, B	IPR015615	Transforming growth factor-beta-related	Family
A, B	IPR001111	TGF-beta, propeptide	Domain
C	IPR000472	Activin types I and II receptor domain	Domain
C	IPR000719	Protein kinase domain	Domain
C	IPR003605	GS domain	Domain
C	IPR017441	Protein kinase, ATP binding site	Binding Site
C	IPR008271	Serine/threonine-protein kinase, active site	Active Site
C	IPR000333	Ser/Thr protein kinase, TGFB receptor	Family
C	IPR045860	Snake toxin-like superfamily	Homologous Superfamily
C	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
D	IPR000472	Activin types I and II receptor domain	Domain
D	IPR000719	Protein kinase domain	Domain
D	IPR000333	Ser/Thr protein kinase, TGFB receptor	Family
D	IPR045860	Snake toxin-like superfamily	Homologous Superfamily
D	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
D	IPR008271	Serine/threonine-protein kinase, active site	Active Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P12643	craniosynostosis hereditary hemochromatosis brachydactyly type A2 20p12.3 microdeletion syndrome bone disease myopia uremia breast carcinoma colorectal cancer Fracture osteosarcoma gastric neoplasm peripheral arterial disease hemochromatosis type 1 short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies craniosynostosis hereditary hemochromatosis brachydactyly type A2 20p12.3 microdeletion syndrome bone disease myopia uremia breast carcinoma colorectal cancer Fracture osteosarcoma gastric neoplasm peripheral arterial disease hemochromatosis type 1 short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies interstitial cystitis lung adenocarcinoma atopic eczema malignant colon neoplasm malignant mesothelioma non-small cell lung carcinoma ductal breast carcinoma in situ osteonecrosis ovarian cancer glioblastoma psoriasis hereditary diffuse gastric adenocarcinoma spina bifida invasive ductal breast carcinoma trigonocephaly lung cancer malignant ependymoma brachydactyly breast cancer colorectal adenoma Crohn disease oligodendroglioma esophageal adenocarcinoma osteoporosis gastric cancer pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma isolated right ventricular hypoplasia astrocytic tumor lung carcinoma bone fracture malignant glioma medulloblastoma nasopharyngeal carcinoma cutaneous lupus erythematosus osteoarthritis
C	Pharos: P36894	polyposis syndrome, hereditary mixed, 2 generalized juvenile polyposis/juvenile polyposis coli juvenile polyposis syndrome Craniofacial Abnormalities polyposis syndrome, hereditary mixed, 1 malignant ependymoma pilocytic astrocytoma psoriasis astrocytic tumor cancer osteosarcoma atypical teratoid rhabdoid tumor colorectal cancer gastric adenocarcinoma Lynch syndrome polyposis syndrome, hereditary mixed, 2 generalized juvenile polyposis/juvenile polyposis coli juvenile polyposis syndrome Craniofacial Abnormalities polyposis syndrome, hereditary mixed, 1 malignant ependymoma pilocytic astrocytoma psoriasis astrocytic tumor cancer osteosarcoma atypical teratoid rhabdoid tumor colorectal cancer gastric adenocarcinoma Lynch syndrome ovarian cancer Cowden disease familial colorectal cancer type X
D	Pharos: Q13705	visceral heterotaxy situs inversus heterotaxy, visceral, 4, autosomal right atrial isomerism subependymal giant cell astrocytoma Asplenia Syndrome interstitial cystitis lung cancer osteosarcoma primitive neuroectodermal tumor situs ambiguus atrial fibrillation large cell medulloblastoma malignant mesothelioma Pick disease visceral heterotaxy situs inversus heterotaxy, visceral, 4, autosomal right atrial isomerism subependymal giant cell astrocytoma Asplenia Syndrome interstitial cystitis lung cancer osteosarcoma primitive neuroectodermal tumor situs ambiguus atrial fibrillation large cell medulloblastoma malignant mesothelioma Pick disease atypical teratoid rhabdoid tumor medulloblastoma