2HG4

Structure of the ketosynthase-acyltransferase didomain of module 5 from DEBS.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C	d2hg4c6	Alpha and beta proteins (a/b)	FabD/lysophospholipase-like	FabD/lysophospholipase-like	FabD-like	Catalytic domain from acyl transferase (AT) domain of 6-deoxyerythronolide B synthase (DEBS)	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
C	d2hg4c2	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Thiolase-related	Ketosynthase domain from 6-deoxyerythronolide B synthase (DEBS), C-terminal domain	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
C	d2hg4c3	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Thiolase-related	Ketosynthase domain from 6-deoxyerythronolide B synthase (DEBS), N-terminal domain	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
C	d2hg4c5	Alpha and beta proteins (a+b)	Ferredoxin-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	Probable ACP-binding domain of malonyl-CoA ACP transacylase	Ferredoxin-like domain from acyl transferase (AT) domain of 6-deoxyerythronolide B synthase (DEBS)	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
C	d2hg4c4	Alpha and beta proteins (a+b)	KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like	KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like	KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like	KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
C	d2hg4c1	Coiled coil proteins	Parallel coiled-coil	N-terminal linker of 6-deoxyerythronolide B synthase (DEBS)	N-terminal linker of 6-deoxyerythronolide B synthase (DEBS)	N-terminal linker of 6-deoxyerythronolide B synthase (DEBS)	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
C	d2hg4c7	Peptides	C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like	C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like	C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like	C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
D	d2hg4d6	Alpha and beta proteins (a/b)	FabD/lysophospholipase-like	FabD/lysophospholipase-like	FabD-like	Catalytic domain from acyl transferase (AT) domain of 6-deoxyerythronolide B synthase (DEBS)	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
D	d2hg4d2	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Thiolase-related	Ketosynthase domain from 6-deoxyerythronolide B synthase (DEBS), C-terminal domain	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
D	d2hg4d3	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Thiolase-related	Ketosynthase domain from 6-deoxyerythronolide B synthase (DEBS), N-terminal domain	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
D	d2hg4d5	Alpha and beta proteins (a+b)	Ferredoxin-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	Probable ACP-binding domain of malonyl-CoA ACP transacylase	Ferredoxin-like domain from acyl transferase (AT) domain of 6-deoxyerythronolide B synthase (DEBS)	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
D	d2hg4d4	Alpha and beta proteins (a+b)	KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like	KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like	KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like	KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
D	d2hg4d1	Coiled coil proteins	Parallel coiled-coil	N-terminal linker of 6-deoxyerythronolide B synthase (DEBS)	N-terminal linker of 6-deoxyerythronolide B synthase (DEBS)	N-terminal linker of 6-deoxyerythronolide B synthase (DEBS)	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
D	d2hg4d7	Peptides	C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like	C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like	C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like	C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
A	d2hg4a6	Alpha and beta proteins (a/b)	FabD/lysophospholipase-like	FabD/lysophospholipase-like	FabD-like	Catalytic domain from acyl transferase (AT) domain of 6-deoxyerythronolide B synthase (DEBS)	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
A	d2hg4a2	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Thiolase-related	Ketosynthase domain from 6-deoxyerythronolide B synthase (DEBS), C-terminal domain	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
A	d2hg4a3	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Thiolase-related	Ketosynthase domain from 6-deoxyerythronolide B synthase (DEBS), N-terminal domain	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
A	d2hg4a5	Alpha and beta proteins (a+b)	Ferredoxin-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	Probable ACP-binding domain of malonyl-CoA ACP transacylase	Ferredoxin-like domain from acyl transferase (AT) domain of 6-deoxyerythronolide B synthase (DEBS)	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
A	d2hg4a4	Alpha and beta proteins (a+b)	KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like	KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like	KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like	KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
A	d2hg4a1	Coiled coil proteins	Parallel coiled-coil	N-terminal linker of 6-deoxyerythronolide B synthase (DEBS)	N-terminal linker of 6-deoxyerythronolide B synthase (DEBS)	N-terminal linker of 6-deoxyerythronolide B synthase (DEBS)	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
A	d2hg4a7	Peptides	C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like	C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like	C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like	C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
B	d2hg4b6	Alpha and beta proteins (a/b)	FabD/lysophospholipase-like	FabD/lysophospholipase-like	FabD-like	Catalytic domain from acyl transferase (AT) domain of 6-deoxyerythronolide B synthase (DEBS)	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
B	d2hg4b2	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Thiolase-related	Ketosynthase domain from 6-deoxyerythronolide B synthase (DEBS), C-terminal domain	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
B	d2hg4b3	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Thiolase-related	Ketosynthase domain from 6-deoxyerythronolide B synthase (DEBS), N-terminal domain	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
B	d2hg4b5	Alpha and beta proteins (a+b)	Ferredoxin-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	Probable ACP-binding domain of malonyl-CoA ACP transacylase	Ferredoxin-like domain from acyl transferase (AT) domain of 6-deoxyerythronolide B synthase (DEBS)	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
B	d2hg4b4	Alpha and beta proteins (a+b)	KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like	KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like	KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like	KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
B	d2hg4b1	Coiled coil proteins	Parallel coiled-coil	N-terminal linker of 6-deoxyerythronolide B synthase (DEBS)	N-terminal linker of 6-deoxyerythronolide B synthase (DEBS)	N-terminal linker of 6-deoxyerythronolide B synthase (DEBS)	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
B	d2hg4b7	Peptides	C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like	C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like	C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like	C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
E	d2hg4e6	Alpha and beta proteins (a/b)	FabD/lysophospholipase-like	FabD/lysophospholipase-like	FabD-like	Catalytic domain from acyl transferase (AT) domain of 6-deoxyerythronolide B synthase (DEBS)	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
E	d2hg4e2	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Thiolase-related	Ketosynthase domain from 6-deoxyerythronolide B synthase (DEBS), C-terminal domain	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
E	d2hg4e3	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Thiolase-related	Ketosynthase domain from 6-deoxyerythronolide B synthase (DEBS), N-terminal domain	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
E	d2hg4e5	Alpha and beta proteins (a+b)	Ferredoxin-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	Probable ACP-binding domain of malonyl-CoA ACP transacylase	Ferredoxin-like domain from acyl transferase (AT) domain of 6-deoxyerythronolide B synthase (DEBS)	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
E	d2hg4e4	Alpha and beta proteins (a+b)	KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like	KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like	KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like	KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
E	d2hg4e1	Coiled coil proteins	Parallel coiled-coil	N-terminal linker of 6-deoxyerythronolide B synthase (DEBS)	N-terminal linker of 6-deoxyerythronolide B synthase (DEBS)	N-terminal linker of 6-deoxyerythronolide B synthase (DEBS)	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
E	d2hg4e7	Peptides	C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like	C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like	C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like	C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
F	d2hg4f6	Alpha and beta proteins (a/b)	FabD/lysophospholipase-like	FabD/lysophospholipase-like	FabD-like	Catalytic domain from acyl transferase (AT) domain of 6-deoxyerythronolide B synthase (DEBS)	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
F	d2hg4f2	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Thiolase-related	Ketosynthase domain from 6-deoxyerythronolide B synthase (DEBS), C-terminal domain	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
F	d2hg4f3	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Thiolase-related	Ketosynthase domain from 6-deoxyerythronolide B synthase (DEBS), N-terminal domain	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
F	d2hg4f5	Alpha and beta proteins (a+b)	Ferredoxin-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	Probable ACP-binding domain of malonyl-CoA ACP transacylase	Ferredoxin-like domain from acyl transferase (AT) domain of 6-deoxyerythronolide B synthase (DEBS)	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
F	d2hg4f4	Alpha and beta proteins (a+b)	KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like	KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like	KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)-like	KS-to-AT linker domain from 6-deoxyerythronolide B synthase (DEBS)	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
F	d2hg4f1	Coiled coil proteins	Parallel coiled-coil	N-terminal linker of 6-deoxyerythronolide B synthase (DEBS)	N-terminal linker of 6-deoxyerythronolide B synthase (DEBS)	N-terminal linker of 6-deoxyerythronolide B synthase (DEBS)	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)
F	d2hg4f7	Peptides	C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like	C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like	C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)-like	C-terminal linker of 6-deoxyerythronolide B synthase (DEBS)	(Saccharopolyspora erythraea ) [TaxId: 1836 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	PKS docking domain-like	8055901	3002322	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Thiolase-like	8055904	3000122	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	FabD/lysophospholipase-like	8055906	3001121	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	FabD/lysophospholipase-like	8055906	3001121	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Probable ACP-binding domain of malonyl-CoA ACP transacylase	8055908	3001224	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	KASAT domain-like	8055902	3002319	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	KASAT domain-like	8055902	3002319	SCOP2B (2022-06-29)
D	SCOP2 Family	KASAT domain-like	8045098	4004293	SCOP2 (2022-06-29)
D	SCOP2 Family	PKS docking region-like	8051502	4007409	SCOP2 (2022-06-29)
D	SCOP2 Family	Thiolase-related	8055903	4000245	SCOP2 (2022-06-29)
D	SCOP2 Family	FabD-like	8055905	4003614	SCOP2 (2022-06-29)
D	SCOP2 Family	Probable ACP-binding domain of malonyl-CoA ACP transacylase	8055907	4001289	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	KASAT domain-like	8055902	3002319	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	PKS docking domain-like	8055901	3002322	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	Thiolase-like	8055904	3000122	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	FabD/lysophospholipase-like	8055906	3001121	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	Probable ACP-binding domain of malonyl-CoA ACP transacylase	8055908	3001224	SCOP2 (2022-06-29)
A	SCOP2B Superfamily	KASAT domain-like	8055902	3002319	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Thiolase-like	8055904	3000122	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	FabD/lysophospholipase-like	8055906	3001121	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	KASAT domain-like	8055902	3002319	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	FabD/lysophospholipase-like	8055906	3001121	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Probable ACP-binding domain of malonyl-CoA ACP transacylase	8055908	3001224	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	PKS docking domain-like	8055901	3002322	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Thiolase-like	8055904	3000122	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	PKS docking domain-like	8055901	3002322	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	KASAT domain-like	8055902	3002319	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	FabD/lysophospholipase-like	8055906	3001121	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Probable ACP-binding domain of malonyl-CoA ACP transacylase	8055908	3001224	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	KASAT domain-like	8055902	3002319	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	FabD/lysophospholipase-like	8055906	3001121	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	KASAT domain-like	8055902	3002319	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Thiolase-like	8055904	3000122	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Probable ACP-binding domain of malonyl-CoA ACP transacylase	8055908	3001224	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	KASAT domain-like	8055902	3002319	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	FabD/lysophospholipase-like	8055906	3001121	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	FabD/lysophospholipase-like	8055906	3001121	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Thiolase-like	8055904	3000122	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	KASAT domain-like	8055902	3002319	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	FabD/lysophospholipase-like	8055906	3001121	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	KASAT domain-like	8055902	3002319	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	FabD/lysophospholipase-like	8055906	3001121	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Probable ACP-binding domain of malonyl-CoA ACP transacylase	8055908	3001224	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	Docking_1	e2hg4C7	A: alpha duplicates or obligate multimers	X: Docking domains in modular polyketide synthases	H: Class 1 N-terminal docking domain (From Topology)	T: Class 1 N-terminal docking domain	F: Docking_1	ECOD (1.6)
C	Acyl_transf_1_2nd_1	e2hg4C2	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: Acyl_transf_1_2nd_1	ECOD (1.6)
C	PksD_2	e2hg4C4	A: a+b two layers	X: KS-MAT linker domain in fatty acid synthase (From Topology)	H: KS-MAT linker domain in fatty acid synthase (From Topology)	T: KS-MAT linker domain in fatty acid synthase	F: PksD_2	ECOD (1.6)
C	Acyl_transf_1_1st	e2hg4C8	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: FabD/lysophospholipase-like	F: Acyl_transf_1_1st	ECOD (1.6)
C	ketoacyl-synt	e2hg4C5	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: ketoacyl-synt	ECOD (1.6)
C	Ketoacyl-synt_C	e2hg4C6	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: Ketoacyl-synt_C	ECOD (1.6)
D	Docking_1	e2hg4D7	A: alpha duplicates or obligate multimers	X: Docking domains in modular polyketide synthases	H: Class 1 N-terminal docking domain (From Topology)	T: Class 1 N-terminal docking domain	F: Docking_1	ECOD (1.6)
D	Acyl_transf_1_2nd_1	e2hg4D4	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: Acyl_transf_1_2nd_1	ECOD (1.6)
D	PksD_2	e2hg4D3	A: a+b two layers	X: KS-MAT linker domain in fatty acid synthase (From Topology)	H: KS-MAT linker domain in fatty acid synthase (From Topology)	T: KS-MAT linker domain in fatty acid synthase	F: PksD_2	ECOD (1.6)
D	Acyl_transf_1_1st	e2hg4D8	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: FabD/lysophospholipase-like	F: Acyl_transf_1_1st	ECOD (1.6)
D	ketoacyl-synt	e2hg4D5	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: ketoacyl-synt	ECOD (1.6)
D	Ketoacyl-synt_C	e2hg4D6	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: Ketoacyl-synt_C	ECOD (1.6)
A	Docking_1	e2hg4A7	A: alpha duplicates or obligate multimers	X: Docking domains in modular polyketide synthases	H: Class 1 N-terminal docking domain (From Topology)	T: Class 1 N-terminal docking domain	F: Docking_1	ECOD (1.6)
A	Acyl_transf_1_2nd_1	e2hg4A3	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: Acyl_transf_1_2nd_1	ECOD (1.6)
A	PksD_2	e2hg4A1	A: a+b two layers	X: KS-MAT linker domain in fatty acid synthase (From Topology)	H: KS-MAT linker domain in fatty acid synthase (From Topology)	T: KS-MAT linker domain in fatty acid synthase	F: PksD_2	ECOD (1.6)
A	Acyl_transf_1_1st	e2hg4A8	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: FabD/lysophospholipase-like	F: Acyl_transf_1_1st	ECOD (1.6)
A	ketoacyl-synt	e2hg4A4	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: ketoacyl-synt	ECOD (1.6)
A	Ketoacyl-synt_C	e2hg4A6	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: Ketoacyl-synt_C	ECOD (1.6)
B	Docking_1	e2hg4B7	A: alpha duplicates or obligate multimers	X: Docking domains in modular polyketide synthases	H: Class 1 N-terminal docking domain (From Topology)	T: Class 1 N-terminal docking domain	F: Docking_1	ECOD (1.6)
B	Acyl_transf_1_2nd_1	e2hg4B3	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: Acyl_transf_1_2nd_1	ECOD (1.6)
B	PksD_2	e2hg4B4	A: a+b two layers	X: KS-MAT linker domain in fatty acid synthase (From Topology)	H: KS-MAT linker domain in fatty acid synthase (From Topology)	T: KS-MAT linker domain in fatty acid synthase	F: PksD_2	ECOD (1.6)
B	Acyl_transf_1_1st	e2hg4B8	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: FabD/lysophospholipase-like	F: Acyl_transf_1_1st	ECOD (1.6)
B	ketoacyl-synt	e2hg4B5	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: ketoacyl-synt	ECOD (1.6)
B	Ketoacyl-synt_C	e2hg4B6	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: Ketoacyl-synt_C	ECOD (1.6)
E	Acyl_transf_1_2nd_1	e2hg4E3	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: Acyl_transf_1_2nd_1	ECOD (1.6)
E	PksD_2	e2hg4E4	A: a+b two layers	X: KS-MAT linker domain in fatty acid synthase (From Topology)	H: KS-MAT linker domain in fatty acid synthase (From Topology)	T: KS-MAT linker domain in fatty acid synthase	F: PksD_2	ECOD (1.6)
E	Acyl_transf_1_1st	e2hg4E7	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: FabD/lysophospholipase-like	F: Acyl_transf_1_1st	ECOD (1.6)
E	ketoacyl-synt	e2hg4E5	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: ketoacyl-synt	ECOD (1.6)
E	Ketoacyl-synt_C	e2hg4E6	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: Ketoacyl-synt_C	ECOD (1.6)
F	Acyl_transf_1_2nd_1	e2hg4F5	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: Acyl_transf_1_2nd_1	ECOD (1.6)
F	PksD_2	e2hg4F2	A: a+b two layers	X: KS-MAT linker domain in fatty acid synthase (From Topology)	H: KS-MAT linker domain in fatty acid synthase (From Topology)	T: KS-MAT linker domain in fatty acid synthase	F: PksD_2	ECOD (1.6)
F	Acyl_transf_1_1st	e2hg4F7	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: FabD/lysophospholipase-like	F: Acyl_transf_1_1st	ECOD (1.6)
F	Ketoacyl-synt_C	e2hg4F6	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: Ketoacyl-synt_C	ECOD (1.6)
F	ketoacyl-synt,Docking_1	e2hg4F4	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: ketoacyl-synt,Docking_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)
C	3.30.70.3290	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
C	3.40.366.10	Alpha Beta	3-Layer(aba) Sandwich	Malonyl-Coenzyme A Acyl Carrier Protein	domain 2	CATH (4.3.0)
D	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)
D	3.30.70.3290	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
D	3.40.366.10	Alpha Beta	3-Layer(aba) Sandwich	Malonyl-Coenzyme A Acyl Carrier Protein	domain 2	CATH (4.3.0)
A	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)
A	3.30.70.3290	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
A	3.40.366.10	Alpha Beta	3-Layer(aba) Sandwich	Malonyl-Coenzyme A Acyl Carrier Protein	domain 2	CATH (4.3.0)
B	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)
B	3.30.70.3290	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
B	3.40.366.10	Alpha Beta	3-Layer(aba) Sandwich	Malonyl-Coenzyme A Acyl Carrier Protein	domain 2	CATH (4.3.0)
E	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)
E	3.30.70.3290	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
E	3.40.366.10	Alpha Beta	3-Layer(aba) Sandwich	Malonyl-Coenzyme A Acyl Carrier Protein	domain 2	CATH (4.3.0)
F	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)
F	3.30.70.3290	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
F	3.40.366.10	Alpha Beta	3-Layer(aba) Sandwich	Malonyl-Coenzyme A Acyl Carrier Protein	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF02801	Beta-ketoacyl synthase, C-terminal domain (Ketoacyl-synt_C)	Beta-ketoacyl synthase, C-terminal domain	The structure of beta-ketoacyl synthase is similar to that of the thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains.	Domain
A, B, C, D, E A, B, C, D, E, F	PF00109	Beta-ketoacyl synthase, N-terminal domain (ketoacyl-synt)	Beta-ketoacyl synthase, N-terminal domain	The structure of beta-ketoacyl synthase is similar to that of the thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. The N-terminal domain contains m ...	The structure of beta-ketoacyl synthase is similar to that of the thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. The N-terminal domain contains most of the structures involved in dimer formation and also the active site cysteine [1].	Domain
A, B, C, D, E A, B, C, D, E, F	PF16197	Ketoacyl-synthetase C-terminal extension (KAsynt_C_assoc)	Ketoacyl-synthetase C-terminal extension	-	Family
A, B, C, D, E A, B, C, D, E, F	PF08990	Erythronolide synthase docking domain (Docking)	Erythronolide synthase docking domain	Polyketide synthase (PKS) catalyzes the biosynthesis of polyketides, which are structurally and functionally diverse natural products in microorganisms and plants [1]. Type I modular PKSs are the large, multifunctional enzymes responsible for the pro ...	Polyketide synthase (PKS) catalyzes the biosynthesis of polyketides, which are structurally and functionally diverse natural products in microorganisms and plants [1]. Type I modular PKSs are the large, multifunctional enzymes responsible for the production of a diverse family of structurally rich and often biologically active natural products. The efficiency of acyl transfer at the interfaces of the individual PKS proteins is thought to be governed by helical regions, termed docking domains (dd). Two such N-terminal domains dimerise to form amphipathic parallel alpha-helical coiled coils: dimerisation is essential for protein function [1].	Domain
A, B, C, D, E A, B, C, D, E, F	PF00698	Acyl transferase domain (Acyl_transf_1)	Acyl transferase domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	6-Deoxyerythronolide B Synthase	vitamin binding amide binding modified amino acid binding binding phosphopantetheine binding small molecule binding acyltransferase activity 3-oxoacyl-[acyl-carrier-protein] synthase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity erythronolide synthase activity fatty acid synthase activity	cellular component biogenesis cellular component organization peptidoglycan-based cell wall biogenesis cellular component assembly cell wall biogenesis DIM/DIP cell wall layer assembly cell wall organization or biogenesis cellular process Actinobacterium-type cell wall biogenesis cellular component organization or biogenesis fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process cellular component biogenesis cellular component organization peptidoglycan-based cell wall biogenesis cellular component assembly cell wall biogenesis DIM/DIP cell wall layer assembly cell wall organization or biogenesis cellular process Actinobacterium-type cell wall biogenesis cellular component organization or biogenesis fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid biosynthetic process organic acid metabolic process fatty acid biosynthetic process carboxylic acid biosynthetic process biosynthetic process small molecule metabolic process metabolic process monocarboxylic acid metabolic process lipid metabolic process macrolide biosynthetic process polyketide metabolic process macrolide metabolic process secondary metabolic process antibiotic biosynthetic process antibiotic metabolic process polyketide biosynthetic process secondary metabolite biosynthetic process lactone metabolic process lactone biosynthetic process	cell periphery cellular anatomical structure plasma membrane membrane intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR016035	Acyl transferase/acyl hydrolase/lysophospholipase	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR014031	Beta-ketoacyl synthase, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F	IPR006162	Phosphopantetheine attachment site	PTM
A, B, C, D, E A, B, C, D, E, F	IPR013968	Polyketide synthase, ketoreductase domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR016036	Malonyl-CoA ACP transacylase, ACP-binding	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR050091	Polyketide and Nonribosomal Peptide Biosynthesis Enzymes	Family
A, B, C, D, E A, B, C, D, E, F	IPR020841	Polyketide synthase, beta-ketoacyl synthase domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR036736	ACP-like superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR014043	Acyl transferase domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR015083	Polyketide synthase, docking domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR032821	Polyketide synthase, C-terminal extension	Domain
A, B, C, D, E A, B, C, D, E, F	IPR009081	Phosphopantetheine binding ACP domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR020806	Polyketide synthase-like, phosphopantetheine-binding domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR036299	Polyketide synthase, docking domain superfmaily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR029058	Alpha/Beta hydrolase fold	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR020802	Polyketide synthase, thioesterase domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR016039	Thiolase-like	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR001227	Acyl transferase domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR018201	Beta-ketoacyl synthase, active site	Active Site
A, B, C, D, E A, B, C, D, E, F	IPR014030	Beta-ketoacyl synthase-like, N-terminal	Domain
A, B, C, D, E A, B, C, D, E, F	IPR001031	Thioesterase	Domain