Annotations: 2KIN

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2kin.1	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	Motor proteins	Kinesin	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B	d2kin.1	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	Motor proteins	Kinesin	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.850.10	Alpha Beta	3-Layer(aba) Sandwich	Kinesin	Kinesin motor domain	CATH (4.3.0)
B	1.20.58.980	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
B	6.10.250.1590	Special	Helix non-globular	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00225	Kinesin motor domain (Kinesin)	Kinesin motor domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	KINESIN	protein binding binding signaling receptor binding apolipoprotein receptor binding microtubule motor activity polypeptide conformation or assembly isomerase activity isomerase activity cytoskeletal motor activity macromolecular conformation isomerase activity catalytic activity ATP-dependent activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding protein binding binding signaling receptor binding apolipoprotein receptor binding microtubule motor activity polypeptide conformation or assembly isomerase activity isomerase activity cytoskeletal motor activity macromolecular conformation isomerase activity catalytic activity ATP-dependent activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cytoskeletal protein binding microtubule binding tubulin binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides	protein localization establishment of protein localization cellular localization nitrogen compound transport protein localization to synapse transport protein transport along microtubule microtubule-based protein transport localization cellular macromolecule localization establishment of localization in cell transport along microtubule anterograde axonal transport axo-dendritic protein transport protein localization establishment of protein localization cellular localization nitrogen compound transport protein localization to synapse transport protein transport along microtubule microtubule-based protein transport localization cellular macromolecule localization establishment of localization in cell transport along microtubule anterograde axonal transport axo-dendritic protein transport anterograde axonal protein transport intracellular transport axonal transport establishment of localization protein localization to presynapse axo-dendritic transport protein transport macromolecule localization microtubule-based transport cellular process microtubule-based process cytoskeleton-dependent intracellular transport microtubule-based movement protein localization to cell junction intracellular protein transport RNA transport nucleic acid transport mRNA transport establishment of RNA localization RNA localization nucleobase-containing compound transport anterograde dendritic transport dendritic transport anterograde dendritic transport of messenger ribonucleoprotein complex multicellular organismal process axonogenesis cellular developmental process cell projection organization motor neuron axon guidance plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development cellular component organization or biogenesis system development developmental process plasma membrane bounded cell projection organization axon guidance nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron projection guidance neuron development intracellular mRNA localization	growth cone axon cell projection cellular anatomical structure distal axon neuron projection axonal growth cone plasma membrane bounded cell projection site of polarized growth somatodendritic compartment dendrite dendritic tree intracellular anatomical structure cytoplasm growth cone axon cell projection cellular anatomical structure distal axon neuron projection axonal growth cone plasma membrane bounded cell projection site of polarized growth somatodendritic compartment dendrite dendritic tree intracellular anatomical structure cytoplasm GABA-ergic synapse synapse cell junction neuron projection cytoplasm cytoplasmic region plasma membrane bounded cell projection cytoplasm dendrite cytoplasm membrane-bounded organelle ciliary rootlet intracellular membraneless organelle cilium intracellular organelle cytoskeleton organelle membraneless organelle cell body neuronal cell body polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton axon cytoplasm cytosolic region postsynapse postsynaptic cytosol cytosol
B	KINESIN	cytoskeletal protein binding protein binding binding kinesin binding microtubule motor activity polypeptide conformation or assembly isomerase activity isomerase activity cytoskeletal motor activity macromolecular conformation isomerase activity catalytic activity ATP-dependent activity scaffold protein binding adenyl ribonucleotide binding nucleotide binding cytoskeletal protein binding protein binding binding kinesin binding microtubule motor activity polypeptide conformation or assembly isomerase activity isomerase activity cytoskeletal motor activity macromolecular conformation isomerase activity catalytic activity ATP-dependent activity scaffold protein binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding microtubule binding tubulin binding protein-containing complex binding plus-end-directed microtubule motor activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides	response to ketone response to stimulus response to chemical response to rotenone response to oxygen-containing compound protein localization establishment of protein localization cellular localization nitrogen compound transport protein localization to synapse transport protein transport along microtubule microtubule-based protein transport localization response to ketone response to stimulus response to chemical response to rotenone response to oxygen-containing compound protein localization establishment of protein localization cellular localization nitrogen compound transport protein localization to synapse transport protein transport along microtubule microtubule-based protein transport localization cellular macromolecule localization establishment of localization in cell transport along microtubule anterograde axonal transport axo-dendritic protein transport anterograde axonal protein transport intracellular transport axonal transport establishment of localization protein localization to presynapse axo-dendritic transport protein transport macromolecule localization microtubule-based transport cellular process microtubule-based process cytoskeleton-dependent intracellular transport microtubule-based movement protein localization to cell junction intracellular protein transport developmental process multicellular organismal process head development forebrain development animal organ development brain development nervous system development pallium development multicellular organism development central nervous system development anatomical structure development telencephalon development hippocampus development limbic system development system development vesicle localization establishment of organelle localization establishment of vesicle localization organelle localization synaptic vesicle localization synaptic vesicle transport diencephalon development thalamus development cellular response to endogenous stimulus cellular response to growth factor stimulus response to endogenous stimulus cellular response to nerve growth factor stimulus response to nerve growth factor response to growth factor cerebral cortex development vesicle cytoskeletal trafficking organelle transport along microtubule dense core granule cytoskeletal transport retrograde neuronal dense core vesicle transport vesicle transport along microtubule dense core granule localization secretory granule localization dense core granule transport retrograde axonal transport cytosolic transport axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation cellular component organization or biogenesis plasma membrane bounded cell projection organization axon guidance axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron projection guidance neuron development cellular response to stimulus response to alcohol cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to alcohol cellular response to ethanol response to ethanol vesicle-mediated transport anterograde dendritic transport dendritic transport anterograde dendritic transport of neurotransmitter receptor complex protein-containing complex localization receptor localization to synapse	somatodendritic compartment cell body cellular anatomical structure perikaryon neuronal cell body growth cone axon cell projection distal axon neuron projection plasma membrane bounded cell projection central region of growth cone site of polarized growth protein-containing complex somatodendritic compartment cell body cellular anatomical structure perikaryon neuronal cell body growth cone axon cell projection distal axon neuron projection plasma membrane bounded cell projection central region of growth cone site of polarized growth protein-containing complex intracellular anatomical structure intracellular membraneless organelle intracellular organelle cytoskeleton organelle membraneless organelle microtubule associated complex kinesin complex microtubule cytoskeleton dendrite dendritic tree cytoplasm neuron projection cytoplasm cytoplasmic region plasma membrane bounded cell projection cytoplasm dendrite cytoplasm membrane-bounded organelle ciliary rootlet cilium perinuclear region of cytoplasm apical dendrite cytoplasmic ribonucleoprotein granule ribonucleoprotein granule supramolecular complex P-body polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer axon cytoplasm cytosolic region postsynapse synapse cell junction postsynaptic cytosol cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
A	IPR001752	Kinesin motor domain	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR027640	Kinesin-like protein	Family
A	IPR019821	Kinesin motor domain, conserved site	Conserved Site
B	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
B	IPR001752	Kinesin motor domain	Domain
B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B	IPR027640	Kinesin-like protein	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.