2LOO | pdb_00002loo

Backbone structure of human membrane protein TMEM14A from NOE data

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Tmemb_14	e2looA1	A: extended segments	X: Transmembrane protein 14A (From Topology)	H: Transmembrane protein 14A (From Topology)	T: Transmembrane protein 14A	F: Tmemb_14	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	6.10.250.1330	Special	Helix non-globular	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
A	1.10.10.1740	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Transmembrane protein 14-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF03647	Transmembrane proteins 14C (Tmemb_14)	Transmembrane proteins 14C	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Transmembrane protein 14A	-	cellular process apoptotic process cell death programmed cell death regulation of biosynthetic process regulation of biological process heme metabolic process pigment metabolic process regulation of cellular process porphyrin-containing compound biosynthetic process tetrapyrrole metabolic process heme biosynthetic process regulation of heme biosynthetic process biological regulation cellular process apoptotic process cell death programmed cell death regulation of biosynthetic process regulation of biological process heme metabolic process pigment metabolic process regulation of cellular process porphyrin-containing compound biosynthetic process tetrapyrrole metabolic process heme biosynthetic process regulation of heme biosynthetic process biological regulation pigment biosynthetic process tetrapyrrole biosynthetic process biosynthetic process regulation of tetrapyrrole metabolic process metabolic process regulation of tetrapyrrole biosynthetic process porphyrin-containing compound metabolic process regulation of metabolic process cellular response to stimulus regulation of localization response to stimulus apoptotic mitochondrial changes negative regulation of biological process regulation of signal transduction regulation of programmed cell death cell communication localization negative regulation of apoptotic signaling pathway regulation of biological quality positive regulation of membrane permeability signal transduction negative regulation of cellular component organization negative regulation of programmed cell death regulation of apoptotic process establishment of localization regulation of organelle organization negative regulation of apoptotic process regulation of response to stimulus regulation of membrane permeability negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway regulation of mitochondrial membrane permeability involved in apoptotic process regulation of apoptotic signaling pathway regulation of cellular component organization negative regulation of mitochondrial membrane permeability transport signaling negative regulation of signaling mitochondrial outer membrane permeabilization involved in programmed cell death negative regulation of cell communication mitochondrial membrane organization cellular component organization positive regulation of mitochondrial membrane permeability involved in apoptotic process negative regulation of cellular process positive regulation of mitochondrial membrane permeability cellular component organization or biogenesis regulation of mitochondrial membrane permeability mitochondrial transport mitochondrion organization membrane organization regulation of signaling regulation of transport negative regulation of response to stimulus negative regulation of signal transduction apoptotic signaling pathway organelle organization negative regulation of organelle organization regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway regulation of mitochondrion organization regulation of cell communication negative regulation of membrane permeability mitochondrial outer membrane permeabilization	membrane-bounded organelle intracellular anatomical structure organelle subcompartment membrane intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane membrane-bounded organelle intracellular anatomical structure organelle subcompartment membrane intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum membrane mitochondrial membrane mitochondrion organelle envelope mitochondrial envelope

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR005349	TMEM14 family	Family
A	IPR044890	TMEM14 superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9Y6G1	acute myeloid leukemia glioblastoma lung carcinoma malignant mesothelioma osteosarcoma pituitary cancer astrocytic tumor large cell medulloblastoma malignant ependymoma medulloblastoma ovarian cancer plasma cell myeloma atypical teratoid rhabdoid tumor lung cancer malignant glioma acute myeloid leukemia glioblastoma lung carcinoma malignant mesothelioma osteosarcoma pituitary cancer astrocytic tumor large cell medulloblastoma malignant ependymoma medulloblastoma ovarian cancer plasma cell myeloma atypical teratoid rhabdoid tumor lung cancer malignant glioma non-small cell lung carcinoma Pick disease

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A	MemProtMD	Annotated as membrane protein by MemProtMD

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.