2N8H | pdb_00002n8h

Structural basis for the inhibition of voltage-gated sodium channels with conotoxin-muOxi-GVIIJ

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Protein Modification Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Conotoxin_like_1	e2n8hA1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: omega toxin-related	F: Conotoxin_like_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02950	Conotoxin (Conotoxin)	Conotoxin	Conotoxins are small snail toxins that block ion channels.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	conotoxin-muOxi-GVIIJ	channel regulator activity ion channel inhibitor activity monoatomic ion channel activity ion channel regulator activity molecular function inhibitor activity passive transmembrane transporter activity transporter inhibitor activity channel activity molecular function regulator activity monoatomic ion transmembrane transporter activity transporter activity transporter regulator activity channel inhibitor activity transmembrane transporter activity channel regulator activity ion channel inhibitor activity monoatomic ion channel activity ion channel regulator activity molecular function inhibitor activity passive transmembrane transporter activity transporter inhibitor activity channel activity molecular function regulator activity monoatomic ion transmembrane transporter activity transporter activity transporter regulator activity channel inhibitor activity transmembrane transporter activity monoatomic cation transmembrane transporter activity sodium channel activity sodium ion transmembrane transporter activity monoatomic cation channel activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity sodium channel regulator activity metal ion transmembrane transporter activity toxin activity	-	cellular anatomical structure extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR004214	Conotoxin	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM	Monotopic/peripheral	All beta monotopic/peripheral	Omega conotoxin-like knottin	Conotoxin O1

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	HYP	Parent Component: PRO RESID: AA0030 PSI-MOD : 4-hydroxy-L-proline MOD:00039

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.