Annotations: 2QG1

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PDZ	e2qg1A1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Multiple PDZ domain protein	-	tight junction organization cellular component organization cellular component biogenesis cell junction organization cellular component assembly tight junction assembly cell junction assembly cellular process cellular component organization or biogenesis cell-cell junction assembly cell-cell junction organization	cellular anatomical structure apical part of cell cell periphery membrane plasma membrane plasma membrane region apical plasma membrane postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization organelle synapse cell junction cellular anatomical structure apical part of cell cell periphery membrane plasma membrane plasma membrane region apical plasma membrane postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization organelle synapse cell junction asymmetric synapse cell-cell junction apical junction complex bicellular tight junction tight junction anchoring junction somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection intracellular anatomical structure cytoplasm apicolateral plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR004172	L27 domain	Domain
A	IPR036034	PDZ superfamily	Homologous Superfamily
A	IPR036892	L27 domain superfamily	Homologous Superfamily
A	IPR032078	Multiple PDZ domain protein, unstructured region	Domain
A	IPR051342	PDZ domain-containing scaffold protein	Family
A	IPR001478	PDZ domain	Domain
A	IPR015132	L27-2	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O75970	hydrocephalus, nonsyndromic, autosomal recessive 2 hydrocephalus visual epilepsy Jacksonian Seizure lung cancer malignant mesothelioma non-small cell lung carcinoma osteosarcoma alcohol withdrawal pancreatic intraductal papillary-mucinous neoplasm intellectual disability large cell medulloblastoma lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia hydrocephalus, nonsyndromic, autosomal recessive 2 hydrocephalus visual epilepsy Jacksonian Seizure lung cancer malignant mesothelioma non-small cell lung carcinoma osteosarcoma alcohol withdrawal pancreatic intraductal papillary-mucinous neoplasm intellectual disability large cell medulloblastoma lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia cystic fibrosis sinusitis invasive ductal breast carcinoma lung adenocarcinoma malignant ependymoma alcohol abuse pancreatic intraductal papillary-mucinous carcinoma progressive supranuclear palsy

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.