Annotations: 2QKU

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PDZ	e2qkuB1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ	ECOD (1.6)
C	PDZ	e2qkuC1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ	ECOD (1.6)
A	PDZ	e2qkuA1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
C	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
A	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Inactivation-no-after-potential D protein	cytoskeletal protein binding protein binding binding myosin binding myosin III binding calmodulin binding molecular transducer activity photoreceptor activity signaling receptor activity signaling receptor complex adaptor activity protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity	cellular response to stimulus response to light stimulus regulation of cellular process response to stimulus regulation of response to external stimulus signaling negative regulation of signaling regulation of opsin-mediated signaling pathway negative regulation of biological process regulation of signal transduction detection of abiotic stimulus negative regulation of G protein-coupled receptor signaling pathway negative regulation of cell communication cellular response to environmental stimulus cell communication cellular response to stimulus response to light stimulus regulation of cellular process response to stimulus regulation of response to external stimulus signaling negative regulation of signaling regulation of opsin-mediated signaling pathway negative regulation of biological process regulation of signal transduction detection of abiotic stimulus negative regulation of G protein-coupled receptor signaling pathway negative regulation of cell communication cellular response to environmental stimulus cell communication cellular response to light stimulus negative regulation of cellular process signal transduction regulation of G protein-coupled receptor signaling pathway negative regulation of opsin-mediated signaling pathway detection of light stimulus phototransduction detection of external stimulus regulation of biological process regulation of signaling negative regulation of response to stimulus biological regulation response to external stimulus detection of visible light cellular response to radiation negative regulation of signal transduction detection of stimulus regulation of response to stimulus negative regulation of response to external stimulus regulation of cell communication response to radiation response to abiotic stimulus cellular process G protein-coupled receptor signaling pathway cellular response to abiotic stimulus G protein-coupled opsin signaling pathway phototransduction, visible light protein localization localization cellular localization cellular macromolecule localization macromolecule localization multicellular organismal process system process sensory perception nervous system process sensory perception of sound sensory perception of mechanical stimulus sensory perception of light stimulus visual perception detection of light stimulus involved in sensory perception detection of stimulus involved in sensory perception	cell projection rhabdomere cellular anatomical structure plasma membrane bounded cell projection protein-containing complex extrinsic component of plasma membrane plasma membrane protein complex membrane plasma membrane membrane protein complex inaD signaling complex cell periphery extrinsic component of membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR036034	PDZ superfamily	Homologous Superfamily
A, B, C	IPR051342	PDZ domain-containing scaffold protein	Family
A, B, C	IPR001478	PDZ domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.