2QY0 | pdb_00002qy0

Active dimeric structure of the catalytic domain of C1r reveals enzyme-product like contacts

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2qy0a1	Small proteins	Complement control module/SCR domain	Complement control module/SCR domain	Complement control module/SCR domain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2qy0a3	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d2qy0c1	Small proteins	Complement control module/SCR domain	Complement control module/SCR domain	Complement control module/SCR domain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d2qy0c3	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2qy0b_	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d2qy0d_	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2 Family	Eukaryotic proteases	8024114	4000286	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Trypsin-like serine proteases	8036493	3000114	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	Trypsin-like serine proteases	8036493	3000114	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Sushi	e2qy0A2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi	ECOD (1.6)
A	Sushi_3	e2qy0A1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi_3	ECOD (1.6)
C	Sushi	e2qy0C1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi	ECOD (1.6)
C	Sushi_3	e2qy0C2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi_3	ECOD (1.6)
B	Trypsin	e2qy0B1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: Trypsin	ECOD (1.6)
D	Trypsin	e2qy0D1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: Trypsin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.10.70.10	Mainly Beta	Ribbon	Complement Module	domain 1	CATH (4.3.0)
C	2.10.70.10	Mainly Beta	Ribbon	Complement Module	domain 1	CATH (4.3.0)
B	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (4.3.0)
D	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF00084	Sushi repeat (SCR repeat) (Sushi)	Sushi repeat (SCR repeat)		Domain
B, D	PF00089	Trypsin (Trypsin)	Trypsin		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Complement C1r subcomponent	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity molecular sequestering activity identical protein binding protein binding	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity humoral immune response response to stimulus positive regulation of biological process positive regulation of response to stimulus complement activation humoral immune response mediated by circulating immunoglobulin positive regulation of immune response leukocyte mediated immunity regulation of immune system process positive regulation of immune system process complement activation, classical pathway regulation of biological process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity humoral immune response response to stimulus positive regulation of biological process positive regulation of response to stimulus complement activation humoral immune response mediated by circulating immunoglobulin positive regulation of immune response leukocyte mediated immunity regulation of immune system process positive regulation of immune system process complement activation, classical pathway regulation of biological process immune response biological regulation immunoglobulin mediated immune response adaptive immune response immune effector process regulation of response to stimulus immune system process B cell mediated immunity regulation of immune response activation of immune response biological process involved in interspecies interaction between organisms response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to other organism response to stress innate immune response response to external biotic stimulus zymogen activation primary metabolic process gene expression macromolecule biosynthetic process protein maturation biosynthetic process proteolysis protein processing metabolic process cellular process protein metabolic process macromolecule metabolic process	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle blood microparticle
B, D	Complement C1r subcomponent	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity molecular sequestering activity identical protein binding protein binding	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity humoral immune response response to stimulus positive regulation of biological process positive regulation of response to stimulus complement activation humoral immune response mediated by circulating immunoglobulin positive regulation of immune response leukocyte mediated immunity regulation of immune system process positive regulation of immune system process complement activation, classical pathway regulation of biological process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity humoral immune response response to stimulus positive regulation of biological process positive regulation of response to stimulus complement activation humoral immune response mediated by circulating immunoglobulin positive regulation of immune response leukocyte mediated immunity regulation of immune system process positive regulation of immune system process complement activation, classical pathway regulation of biological process immune response biological regulation immunoglobulin mediated immune response adaptive immune response immune effector process regulation of response to stimulus immune system process B cell mediated immunity regulation of immune response activation of immune response biological process involved in interspecies interaction between organisms response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to other organism response to stress innate immune response response to external biotic stimulus zymogen activation primary metabolic process gene expression macromolecule biosynthetic process protein maturation biosynthetic process proteolysis protein processing metabolic process cellular process protein metabolic process macromolecule metabolic process	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle blood microparticle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR018097	EGF-like calcium-binding, conserved site	Conserved Site
A, C	IPR035914	Spermadhesin, CUB domain superfamily	Homologous Superfamily
A, C	IPR000436	Sushi/SCR/CCP domain	Domain
A, C	IPR000859	CUB domain	Domain
A, C	IPR000742	EGF-like domain	Domain
A, C	IPR035976	Sushi/SCR/CCP superfamily	Homologous Superfamily
A, C	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A, C	IPR001314	Peptidase S1A, chymotrypsin family	Family
A, C	IPR033116	Serine proteases, trypsin family, serine active site	Active Site
A, C	IPR001254	Serine proteases, trypsin domain	Domain
A, C	IPR001881	EGF-like calcium-binding domain	Domain
A, C	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
A, C	IPR024175	Peptidase S1A, complement C1r/C1S/mannan-binding	Family
B, D	IPR018097	EGF-like calcium-binding, conserved site	Conserved Site
B, D	IPR035914	Spermadhesin, CUB domain superfamily	Homologous Superfamily
B, D	IPR000436	Sushi/SCR/CCP domain	Domain
B, D	IPR000859	CUB domain	Domain
B, D	IPR000742	EGF-like domain	Domain
B, D	IPR035976	Sushi/SCR/CCP superfamily	Homologous Superfamily
B, D	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
B, D	IPR001314	Peptidase S1A, chymotrypsin family	Family
B, D	IPR033116	Serine proteases, trypsin family, serine active site	Active Site
B, D	IPR001254	Serine proteases, trypsin domain	Domain
B, D	IPR001881	EGF-like calcium-binding domain	Domain
B, D	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
B, D	IPR024175	Peptidase S1A, complement C1r/C1S/mannan-binding	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C	Pharos: P00736	Ehlers-Danlos syndrome cystic fibrosis endometriosis paratuberculosis Ehlers-Danlos syndrome, periodontal type 1 large cell medulloblastoma lung carcinoma malignant ependymoma malignant pancreatic neoplasm adrenal cortex carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm Duchenne muscular dystrophy pilocytic astrocytoma Ehlers-Danlos syndrome, periodontitis type Ehlers-Danlos syndrome cystic fibrosis endometriosis paratuberculosis Ehlers-Danlos syndrome, periodontal type 1 large cell medulloblastoma lung carcinoma malignant ependymoma malignant pancreatic neoplasm adrenal cortex carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm Duchenne muscular dystrophy pilocytic astrocytoma Ehlers-Danlos syndrome, periodontitis type subependymal giant cell astrocytoma glioblastoma invasive ductal breast carcinoma limb-girdle muscular dystrophy Lupus Erythematosus, Systemic malignant glioma medulloblastoma Becker muscular dystrophy pancreatic ductal adenocarcinoma dermatomyositis pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pituitary cancer ulcerative colitis facioscapulohumeral muscular dystrophy heart disease juvenile dermatomyositis lung cancer malignant colon neoplasm malignant mesothelioma myopathy complement component C1r/C1s deficiency pancreatic intraductal papillary-mucinous carcinoma diabetes mellitus Sjogren syndrome gastric carcinoma interstitial cystitis
B, D	Pharos: P00736	Ehlers-Danlos syndrome cystic fibrosis endometriosis paratuberculosis Ehlers-Danlos syndrome, periodontal type 1 large cell medulloblastoma lung carcinoma malignant ependymoma malignant pancreatic neoplasm adrenal cortex carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm Duchenne muscular dystrophy pilocytic astrocytoma Ehlers-Danlos syndrome, periodontitis type Ehlers-Danlos syndrome cystic fibrosis endometriosis paratuberculosis Ehlers-Danlos syndrome, periodontal type 1 large cell medulloblastoma lung carcinoma malignant ependymoma malignant pancreatic neoplasm adrenal cortex carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm Duchenne muscular dystrophy pilocytic astrocytoma Ehlers-Danlos syndrome, periodontitis type subependymal giant cell astrocytoma glioblastoma invasive ductal breast carcinoma limb-girdle muscular dystrophy Lupus Erythematosus, Systemic malignant glioma medulloblastoma Becker muscular dystrophy pancreatic ductal adenocarcinoma dermatomyositis pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pituitary cancer ulcerative colitis facioscapulohumeral muscular dystrophy heart disease juvenile dermatomyositis lung cancer malignant colon neoplasm malignant mesothelioma myopathy complement component C1r/C1s deficiency pancreatic intraductal papillary-mucinous carcinoma diabetes mellitus Sjogren syndrome gastric carcinoma interstitial cystitis