2REL | pdb_00002rel

SOLUTION STRUCTURE OF R-ELAFIN, A SPECIFIC INHIBITOR OF ELASTASE, NMR, 11 STRUCTURES

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2rela_	Small proteins	Knottins (small inhibitors, toxins, lectins)	Elafin-like	Elafin-like	Elafin, elastase-specific inhibitor	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Elafin-like	8038372	3000478	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	WAP	e2relA1	A: few secondary structure elements	X: Elafin-like (From Topology)	H: Elafin-like (From Topology)	T: Elafin-like	F: WAP	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	4.10.75.10	Few Secondary Structures	Irregular	R-elafin	Elafin-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00095	WAP-type (Whey Acidic Protein) 'four-disulfide core' (WAP)	WAP-type (Whey Acidic Protein) 'four-disulfide core'	WAP belongs to the group of Elafin or elastase-specific inhibitors.	Domain
A	PF10511	Trappin protein transglutaminase binding domain (Cementoin)	Trappin protein transglutaminase binding domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	R-ELAFIN	enzyme regulator activity molecular function inhibitor activity peptidase regulator activity serine-type endopeptidase inhibitor activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity structural constituent of skin epidermis structural molecule activity	behavior multicellular organismal process reproductive process multicellular organismal reproductive process reproductive behavior mating behavior copulation humoral immune response biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response immune response antibacterial humoral response behavior multicellular organismal process reproductive process multicellular organismal reproductive process reproductive behavior mating behavior copulation humoral immune response biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response immune response antibacterial humoral response defense response to symbiont response to external stimulus antimicrobial humoral response response to biotic stimulus defense response to bacterium defense response to other organism response to stress immune system process response to bacterium response to external biotic stimulus innate immune response peptide cross-linking macromolecule modification metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process protein modification process	cell periphery cellular anatomical structure plasma membrane membrane cornified envelope extracellular region intracellular anatomical structure cytoplasm cytosol extracellular matrix external encapsulating structure extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036645	Elafin-like superfamily	Homologous Superfamily
A	IPR002098	Seminal vesicle protein I	Repeat
A	IPR050514	WAP four-disulfide core domain	Family
A	IPR019541	Trappin protein transglutaminase-binding repeat	Repeat
A	IPR008197	WAP-type 'four-disulfide core' domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P19957	contact dermatitis bipolar disorder psoriasis Contact hypersensitivity

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.