2RR3 | pdb_00002rr3

Solution structure of the complex between human VAP-A MSP domain and human OSBP FFAT motif

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	MSP-like	8061615	4007566	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PapD-like	8061616	3002067	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Motile_Sperm	e2rr3A1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Motile_Sperm	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00635	MSP (Major sperm protein) domain (Motile_Sperm)	MSP (Major sperm protein) domain	Major sperm proteins are involved in sperm motility. These proteins oligomerise to form filaments. This family contains many other proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Vesicle-associated membrane protein-associated protein A	protein binding binding protein domain specific binding protein heterodimerization activity protein dimerization activity FFAT motif binding cytoskeletal protein binding microtubule binding tubulin binding protein-membrane adaptor activity protein-macromolecule adaptor activity molecular adaptor activity identical protein binding protein homodimerization activity protein binding binding protein domain specific binding protein heterodimerization activity protein dimerization activity FFAT motif binding cytoskeletal protein binding microtubule binding tubulin binding protein-membrane adaptor activity protein-macromolecule adaptor activity molecular adaptor activity identical protein binding protein homodimerization activity cell adhesion molecule binding cadherin binding	membrane organization cellular component organization membrane fusion cellular process cellular component organization or biogenesis vesicle budding from membrane cellular localization transport intracellular transport endoplasmic reticulum to Golgi vesicle-mediated transport establishment of localization vesicle-mediated transport vesicle organization localization membrane organization cellular component organization membrane fusion cellular process cellular component organization or biogenesis vesicle budding from membrane cellular localization transport intracellular transport endoplasmic reticulum to Golgi vesicle-mediated transport establishment of localization vesicle-mediated transport vesicle organization localization organelle organization establishment of localization in cell COPII-coated vesicle budding Golgi vesicle transport cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of biological process regulation of signaling biological regulation positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of response to stimulus regulation of cell communication regulation of canonical NF-kappaB signal transduction positive regulation of signaling negative regulation by host of viral genome replication modulation by host of viral process biological process involved in interspecies interaction between organisms viral genome replication viral process viral life cycle negative regulation by host of viral process modulation of process of another organism host-mediated perturbation of symbiont process modulation by host of viral genome replication positive regulation by host of viral process positive regulation by host of viral genome replication nitrogen compound transport ceramide transport amide transport macromolecule localization lipid localization lipid transport phospholipid transport organophosphate ester transport cholesterol transport sterol transport organic hydroxy compound transport membrane lipid metabolic process sphingolipid biosynthetic process lipid biosynthetic process amide biosynthetic process primary metabolic process sphingolipid metabolic process sphingomyelin biosynthetic process phospholipid biosynthetic process phospholipid metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process phosphate-containing compound metabolic process metabolic process amide metabolic process membrane lipid biosynthetic process phosphorus metabolic process sphingomyelin metabolic process lipid metabolic process endoplasmic reticulum-plasma membrane tethering membrane docking endoplasmic reticulum localization endoplasmic reticulum organization organelle localization by membrane tethering organelle localization endomembrane system organization protein localization protein localization to organelle cellular macromolecule localization protein localization to endoplasmic reticulum exit from host cell viral release from host cell biological process involved in interaction with host biological process involved in symbiotic interaction developmental process multicellular organismal process plasma membrane bounded cell projection organization cellular developmental process cell projection organization cell development neuron projection development nervous system development generation of neurons neurogenesis multicellular organism development neuron differentiation cell differentiation neuron development anatomical structure development system development	membrane-bounded organelle cellular anatomical structure organelle vesicle intracellular anatomical structure nuclear membrane membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope nuclear envelope organelle membrane membrane-bounded organelle cellular anatomical structure organelle vesicle intracellular anatomical structure nuclear membrane membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope nuclear envelope organelle membrane intracellular vesicle lytic vacuole bounding membrane of organelle vesicle membrane cytoplasmic vesicle lysosome vacuolar membrane azurophil granule vacuole lytic vacuole membrane cytoplasmic vesicle membrane lysosomal membrane secretory granule primary lysosome secretory vesicle azurophil granule membrane cytoplasm secretory granule membrane cytosol cell periphery plasma membrane cytoskeleton membraneless organelle intracellular membraneless organelle microtubule cytoskeleton organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane Golgi membrane Golgi apparatus cell-cell junction apical junction complex bicellular tight junction tight junction anchoring junction cell junction
B	Oxysterol-binding protein 1	protein binding binding protein domain specific binding sterol binding steroid binding lipid binding sterol transfer activity lipid transporter activity lipid transfer activity transporter activity oxysterol binding phospholipid binding phosphatidylinositol phosphate binding phosphatidylinositol-4-phosphate binding protein binding binding protein domain specific binding sterol binding steroid binding lipid binding sterol transfer activity lipid transporter activity lipid transfer activity transporter activity oxysterol binding phospholipid binding phosphatidylinositol phosphate binding phosphatidylinositol-4-phosphate binding phosphatidylinositol binding	localization nitrogen compound transport ceramide transport transport amide transport macromolecule localization lipid localization lipid transport establishment of localization phospholipid transport organophosphate ester transport membrane lipid metabolic process sphingolipid biosynthetic process lipid biosynthetic process localization nitrogen compound transport ceramide transport transport amide transport macromolecule localization lipid localization lipid transport establishment of localization phospholipid transport organophosphate ester transport membrane lipid metabolic process sphingolipid biosynthetic process lipid biosynthetic process amide biosynthetic process primary metabolic process sphingolipid metabolic process sphingomyelin biosynthetic process phospholipid biosynthetic process phospholipid metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process phosphate-containing compound metabolic process metabolic process cellular process amide metabolic process membrane lipid biosynthetic process phosphorus metabolic process sphingomyelin metabolic process lipid metabolic process bile acid biosynthetic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process steroid metabolic process carboxylic acid metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process bile acid metabolic process small molecule metabolic process monocarboxylic acid metabolic process cellular localization intracellular lipid transport intracellular cholesterol transport intracellular transport organic hydroxy compound transport intracellular sterol transport establishment of localization in cell cholesterol transport sterol transport protein localization cellular response to stimulus positive regulation of cell communication regulation of localization establishment of protein localization regulation of cellular process response to stimulus positive regulation of establishment of protein localization cell communication carbohydrate homeostasis cellular macromolecule localization positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of insulin secretion regulation of biological quality regulation of peptide hormone secretion regulation of biological process regulation of hormone levels positive regulation of peptide hormone secretion establishment of protein localization to extracellular region intracellular glucose homeostasis protein secretion cellular response to oxygen-containing compound regulation of protein secretion regulation of secretion cellular response to carbohydrate stimulus chemical homeostasis response to glucose response to chemical glucose homeostasis positive regulation of protein localization insulin secretion involved in cellular response to glucose stimulus regulation of hormone secretion regulation of protein localization regulation of peptide secretion signaling homeostatic process positive regulation of biological process positive regulation of secretion by cell hormone secretion protein localization to extracellular region positive regulation of protein transport peptide secretion regulation of secretion by cell secretion by cell positive regulation of hormone secretion response to monosaccharide response to carbohydrate positive regulation of secretion signal release cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus positive regulation of cellular process positive regulation of peptide secretion regulation of signaling regulation of transport secretion regulation of peptide transport biological regulation regulation of establishment of protein localization export from cell cell-cell signaling response to oxygen-containing compound cellular response to glucose stimulus regulation of protein transport positive regulation of protein secretion peptide transport response to hexose cellular response to chemical stimulus cellular homeostasis positive regulation of transport protein transport regulation of cellular localization regulation of insulin secretion peptide hormone secretion regulation of insulin secretion involved in cellular response to glucose stimulus hormone transport regulation of cell communication insulin secretion positive regulation of signaling positive regulation of organelle organization regulation of cellular component organization positive regulation of cellular component organization secretory granule organization regulation of secretory granule organization regulation of organelle organization vesicle organization cellular component organization organelle organization cellular component organization or biogenesis positive regulation of secretory granule organization endomembrane system organization	cellular anatomical structure cell junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle cellular anatomical structure cell junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle nuclear lumen membrane cytoplasm cytosol cell periphery plasma membrane nucleoplasm endomembrane system perinuclear endoplasmic reticulum perinuclear region of cytoplasm endoplasmic reticulum organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network organelle membrane endoplasmic reticulum membrane Golgi apparatus subcompartment Golgi apparatus trans-Golgi network Golgi membrane bounding membrane of organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR008962	PapD-like superfamily	Homologous Superfamily
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR000535	Major sperm protein (MSP) domain	Domain
A	IPR016763	Vesicle-associated membrane-protein-associated protein	Family
B	IPR001849	Pleckstrin homology domain	Domain
B	IPR011993	PH-like domain superfamily	Homologous Superfamily
B	IPR018494	Oxysterol-binding protein, conserved site	Conserved Site
B	IPR037239	Oxysterol-binding protein superfamily	Homologous Superfamily
B	IPR000648	Oxysterol-binding protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9P0L0	atypical teratoid rhabdoid tumor breast cancer invasive ductal breast carcinoma malignant ependymoma non-small cell lung carcinoma plasma cell myeloma tuberculosis bipolar disorder breast carcinoma large cell medulloblastoma malignant glioma osteosarcoma psoriasis botulism glioblastoma atypical teratoid rhabdoid tumor breast cancer invasive ductal breast carcinoma malignant ependymoma non-small cell lung carcinoma plasma cell myeloma tuberculosis bipolar disorder breast carcinoma large cell medulloblastoma malignant glioma osteosarcoma psoriasis botulism glioblastoma lymphoplasmacytic lymphoma medulloblastoma ovarian cancer subependymal giant cell astrocytoma
B	Pharos: P22059	colorectal cancer psoriasis osteosarcoma pancreatic ductal adenocarcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.