2UX0

Structure of the oligomerisation domain of calcium-calmodulin dependent protein kinase II gamma

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2ux0a1	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2ux0b_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d2ux0e_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d2ux0f_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d2ux0c_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d2ux0d_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	8024609	4000593	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	NTF2-like	8036988	3000472	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	NTF2-like	8036988	3000472	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	NTF2-like	8036988	3000472	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	NTF2-like	8036988	3000472	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	NTF2-like	8036988	3000472	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	NTF2-like	8036988	3000472	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DUF4440	e2ux0A1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
B	DUF4440	e2ux0B1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
E	DUF4440	e2ux0E1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
F	DUF4440	e2ux0F1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
C	DUF4440	e2ux0C1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
D	DUF4440	e2ux0D1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
B	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
E	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
F	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
C	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
D	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF08332	Calcium/calmodulin dependent protein kinase II association domain (CaMKII_AD)	Calcium/calmodulin dependent protein kinase II association domain	This domain is found at the C-terminus of the Calcium/calmodulin dependent protein kinases II (CaMKII). These proteins also have a Ser/Thr protein kinase domain (Pfam:PF00069) at their N-terminus [1]. The function of the CaMKII association domain i ...	This domain is found at the C-terminus of the Calcium/calmodulin dependent protein kinases II (CaMKII). These proteins also have a Ser/Thr protein kinase domain (Pfam:PF00069) at their N-terminus [1]. The function of the CaMKII association domain is the assembly of the single proteins into large (8 to 14 subunits) multimers [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	CALCIUM-CALMODULIN DEPENDENT PROTEIN KINASE (CAM KINASE) II GAMMA	protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity calcium/calmodulin-dependent protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity hydrolase activity, acting on ester bonds phosphatase activity protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity calcium/calmodulin-dependent protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity calcium-dependent protein serine/threonine phosphatase activity protein serine kinase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding identical protein binding protein binding protein homodimerization activity protein dimerization activity calmodulin binding	developmental process cellular developmental process cell differentiation cellular process regulation of calcium ion transport regulation of localization regulation of biological process transport regulation of transport regulation of monoatomic ion transport biological regulation establishment of localization metal ion transport calcium ion transport developmental process cellular developmental process cell differentiation cellular process regulation of calcium ion transport regulation of localization regulation of biological process transport regulation of transport regulation of monoatomic ion transport biological regulation establishment of localization metal ion transport calcium ion transport localization monoatomic ion transport regulation of metal ion transport monoatomic cation transport regulation of muscle adaptation multicellular organismal process striated muscle adaptation system process response to stimulus regulation of skeletal muscle adaptation regulation of system process muscle system process regulation of muscle system process muscle adaptation regulation of response to stimulus skeletal muscle adaptation regulation of multicellular organismal process protein phosphorylation phosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process multicellular organism development anatomical structure development nervous system development system development regulation of neuron projection development regulation of cellular component organization regulation of cellular process cell projection organization cell development neuron projection development cellular component organization neurogenesis neuron differentiation cellular component organization or biogenesis plasma membrane bounded cell projection organization regulation of cell projection organization generation of neurons neuron development regulation of plasma membrane bounded cell projection organization protein localization establishment of protein localization cellular localization nitrogen compound transport signaling hormone secretion cell communication protein localization to extracellular region peptide secretion secretion by cell amide transport signal release cellular macromolecule localization regulation of biological quality secretion regulation of hormone levels establishment of protein localization to extracellular region cell-cell signaling export from cell protein secretion peptide transport protein transport peptide hormone secretion macromolecule localization hormone transport insulin secretion	cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure organelle subcompartment intracellular membrane-bounded organelle endomembrane system sarcoplasm endoplasmic reticulum subcompartment intracellular organelle bounding membrane of organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure organelle subcompartment intracellular membrane-bounded organelle endomembrane system sarcoplasm endoplasmic reticulum subcompartment intracellular organelle bounding membrane of organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum sarcoplasmic reticulum sarcoplasmic reticulum membrane cytoplasm organelle membrane endoplasmic reticulum membrane cytosol nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen cell projection neuron projection plasma membrane bounded cell projection protein-containing complex catalytic complex calcium- and calmodulin-dependent protein kinase complex intracellular protein-containing complex intracellular vesicle cytoplasmic vesicle membrane cytoplasmic vesicle vesicle membrane endocytic vesicle membrane vesicle endocytic vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR032710	NTF2-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR017441	Protein kinase, ATP binding site	Binding Site
A, B, C, D, E A, B, C, D, E, F	IPR013543	Calcium/calmodulin-dependent protein kinase II, association-domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR000719	Protein kinase domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR008271	Serine/threonine-protein kinase, active site	Active Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F	Pharos: Q13555	psoriasis atypical teratoid rhabdoid tumor glioblastoma inflammatory bowel disease malignant ependymoma medulloblastoma osteosarcoma pituitary cancer subependymal giant cell astrocytoma Crohn disease Hormone receptor positive malignant neoplasm of breast intellectual disability malignant glioma myocardial infarction pancreatic intraductal papillary-mucinous neoplasm psoriasis atypical teratoid rhabdoid tumor glioblastoma inflammatory bowel disease malignant ependymoma medulloblastoma osteosarcoma pituitary cancer subependymal giant cell astrocytoma Crohn disease Hormone receptor positive malignant neoplasm of breast intellectual disability malignant glioma myocardial infarction pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor tuberculosis dermatomyositis large cell medulloblastoma malignant mesothelioma myopathy pilocytic astrocytoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.