2W81

Structure of a complex between Neisseria meningitidis factor H binding protein and CCPs 6-7 of human complement factor H

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Sushi_4	e2w81A2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi_4	ECOD (1.6)
A	Sushi	e2w81A3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi	ECOD (1.6)
E	Sushi_4	e2w81E2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi_4	ECOD (1.6)
E	Sushi	e2w81E1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi	ECOD (1.6)
B	Sushi_4	e2w81B3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi_4	ECOD (1.6)
B	Sushi	e2w81B4	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi	ECOD (1.6)
C	Lipoprot_C_1st	e2w81C2	A: beta barrels	X: Outer membrane meander beta-barrels	H: OMPA-like (From Topology)	T: OMPA-like	F: Lipoprot_C_1st	ECOD (1.6)
C	Lipoprot_C_2nd	e2w81C1	A: beta barrels	X: Factor H-binding protein (fHbp) N-terminal beta-barrel domain (From Topology)	H: Factor H-binding protein (fHbp) N-terminal beta-barrel domain (From Topology)	T: Factor H-binding protein (fHbp) N-terminal beta-barrel domain	F: Lipoprot_C_2nd	ECOD (1.6)
D	Lipoprot_C_1st	e2w81D2	A: beta barrels	X: Outer membrane meander beta-barrels	H: OMPA-like (From Topology)	T: OMPA-like	F: Lipoprot_C_1st	ECOD (1.6)
D	Lipoprot_C_2nd	e2w81D1	A: beta barrels	X: Factor H-binding protein (fHbp) N-terminal beta-barrel domain (From Topology)	H: Factor H-binding protein (fHbp) N-terminal beta-barrel domain (From Topology)	T: Factor H-binding protein (fHbp) N-terminal beta-barrel domain	F: Lipoprot_C_2nd	ECOD (1.6)
F	Lipoprot_C_1st	e2w81F2	A: beta barrels	X: Outer membrane meander beta-barrels	H: OMPA-like (From Topology)	T: OMPA-like	F: Lipoprot_C_1st	ECOD (1.6)
F	Lipoprot_C_2nd	e2w81F1	A: beta barrels	X: Factor H-binding protein (fHbp) N-terminal beta-barrel domain (From Topology)	H: Factor H-binding protein (fHbp) N-terminal beta-barrel domain (From Topology)	T: Factor H-binding protein (fHbp) N-terminal beta-barrel domain	F: Lipoprot_C_2nd	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.10.70.10	Mainly Beta	Ribbon	Complement Module	domain 1	CATH (4.3.0)
E	2.10.70.10	Mainly Beta	Ribbon	Complement Module	domain 1	CATH (4.3.0)
B	2.10.70.10	Mainly Beta	Ribbon	Complement Module	domain 1	CATH (4.3.0)
C	2.60.40.1980	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
C	2.40.160.90	Mainly Beta	Beta Barrel	Porin		CATH (4.3.0)
D	2.60.40.1980	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
D	2.40.160.90	Mainly Beta	Beta Barrel	Porin		CATH (4.3.0)
F	2.60.40.1980	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
F	2.40.160.90	Mainly Beta	Beta Barrel	Porin		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, E	PF00084	Sushi repeat (SCR repeat) (Sushi)	Sushi repeat (SCR repeat)	-	Domain
C, D, F	PF08794	Factor H binding protein, C-terminal (FHBP_C)	Factor H binding protein, C-terminal	Factor H binding protein (also known as GNA1870) is a surface exposed lipoprotein in Neisseria meningitidis that is a potent antigen and a potential candidate for a vaccine against meningococcal disease [1-4]. The structure of the C-terminal domain c ...	Factor H binding protein (also known as GNA1870) is a surface exposed lipoprotein in Neisseria meningitidis that is a potent antigen and a potential candidate for a vaccine against meningococcal disease [1-4]. The structure of the C-terminal domain consists of an anti-parallel beta barrel overlaid by a short alpha helical region [1,5]. This domain is highly similar to Transferrin-binding protein B beta barrel (Pfam:PF01298).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, E	COMPLEMENT FACTOR H	opsonin binding protein binding binding complement component C3b binding complement binding heparin binding glycosaminoglycan binding carbohydrate derivative binding sulfur compound binding identical protein binding heparan sulfate proteoglycan binding proteoglycan binding	regulation of humoral immune response regulation of immune effector process regulation of defense response humoral immune response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms response to stimulus regulation of response to external stimulus positive regulation of biological process complement activation, alternative pathway response to biotic stimulus positive regulation of response to stimulus complement activation positive regulation of immune response response to stress regulation of humoral immune response regulation of immune effector process regulation of defense response humoral immune response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms response to stimulus regulation of response to external stimulus positive regulation of biological process complement activation, alternative pathway response to biotic stimulus positive regulation of response to stimulus complement activation positive regulation of immune response response to stress regulation of response to stress innate immune response regulation of immune system process response to external biotic stimulus positive regulation of immune system process regulation of biological process regulation of complement activation, alternative pathway immune response response to other organism defense response regulation of innate immune response biological regulation defense response to symbiont response to external stimulus immune effector process regulation of response to stimulus immune system process defense response to other organism regulation of immune response regulation of complement activation activation of immune response regulation of cellular process regulation of complement-dependent cytotoxicity cellular process regulation of cell killing complement-dependent cytotoxicity cell killing proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	cellular anatomical structure extracellular region extracellular space blood microparticle extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle vesicle extracellular membrane-bounded organelle protein-containing complex catalytic complex peptidase complex cellular anatomical structure extracellular region extracellular space blood microparticle extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle vesicle extracellular membrane-bounded organelle protein-containing complex catalytic complex peptidase complex endopeptidase complex serine-type endopeptidase complex serine-type peptidase complex other organism part symbiont cell surface
C, D, F	FACTOR H BINDING PROTEIN	-	-	membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle bacterial extracellular vesicle vesicle extracellular membrane-bounded organelle cell periphery cell outer membrane external encapsulating structure membrane cell envelope membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle bacterial extracellular vesicle vesicle extracellular membrane-bounded organelle cell periphery cell outer membrane external encapsulating structure membrane cell envelope outer membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, E	IPR051503	Complement System Regulators and Virion Entry Mediators	Family
A, B, E	IPR000436	Sushi/SCR/CCP domain	Domain
A, B, E	IPR035976	Sushi/SCR/CCP superfamily	Homologous Superfamily
C, D, F	IPR011250	Outer membrane protein/outer membrane enzyme PagP, beta-barrel	Homologous Superfamily
C, D, F	IPR014902	Factor H binding protein-like, C-terminal	Domain
C, D, F	IPR049377	Factor H binding protein, N-terminal	Domain
C, D, F	IPR049378	Factor H binding protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, E	Pharos: P08603	age-related macular degeneration complement factor H deficiency age related macular degeneration 4 basal laminar drusen atypical hemolytic-uremic syndrome hemolytic uremic syndrome, atypical, susceptibility to, 1 membranoproliferative glomerulonephritis meningococcal infection hemolytic-uremic syndrome Doyne honeycomb retinal dystrophy primary immunodeficiency disease IgA glomerulonephritis macular degeneration Emery-Dreifuss muscular dystrophy pituitary cancer age-related macular degeneration complement factor H deficiency age related macular degeneration 4 basal laminar drusen atypical hemolytic-uremic syndrome hemolytic uremic syndrome, atypical, susceptibility to, 1 membranoproliferative glomerulonephritis meningococcal infection hemolytic-uremic syndrome Doyne honeycomb retinal dystrophy primary immunodeficiency disease IgA glomerulonephritis macular degeneration Emery-Dreifuss muscular dystrophy pituitary cancer hemolytic anemia psoriasis interstitial lung disease limb-girdle muscular dystrophy adrenal cortex carcinoma lung carcinoma Antibody Deficiency Syndrome malignant mesothelioma bacterial infectious disease blindness (disorder) non-small cell lung carcinoma pancreatic ductal adenocarcinoma Duchenne muscular dystrophy Pick disease facioscapulohumeral muscular dystrophy retinal degeneration invasive ductal breast carcinoma lung adenocarcinoma atopic eczema medulloblastoma breast carcinoma cystic fibrosis oligodendroglioma drug-induced liver injury pancreatic intraductal papillary-mucinous carcinoma ductal breast carcinoma in situ pilocytic astrocytoma HELLP syndrome primary membranoproliferative glomerulonephritis wet macular degeneration immunoglobulin-mediated membranoproliferative glomerulonephritis juvenile dermatomyositis lung cancer malignant colon neoplasm Becker muscular dystrophy breast fibroadenoma dense deposit disease ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.