2WAS

Structure of the fungal type I FAS PPT domain

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2wasa_	Alpha and beta proteins (a+b)	4'-phosphopantetheinyl transferase	4'-phosphopantetheinyl transferase	automated matches	automated matches	BAKER'S YEAST (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
E	d2wase_	Alpha and beta proteins (a+b)	4'-phosphopantetheinyl transferase	4'-phosphopantetheinyl transferase	automated matches	automated matches	BAKER'S YEAST (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
D	d2wasd_	Alpha and beta proteins (a+b)	4'-phosphopantetheinyl transferase	4'-phosphopantetheinyl transferase	automated matches	automated matches	BAKER'S YEAST (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
B	d2wasb_	Alpha and beta proteins (a+b)	4'-phosphopantetheinyl transferase	4'-phosphopantetheinyl transferase	automated matches	automated matches	BAKER'S YEAST (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
C	d2wasc_	Alpha and beta proteins (a+b)	4'-phosphopantetheinyl transferase	4'-phosphopantetheinyl transferase	automated matches	automated matches	BAKER'S YEAST (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
F	d2wasf_	Alpha and beta proteins (a+b)	4'-phosphopantetheinyl transferase	4'-phosphopantetheinyl transferase	automated matches	automated matches	BAKER'S YEAST (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	4'-phosphopantetheinyl transferase	8074379	3000948	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	4'-phosphopantetheinyl transferase	8074379	3000948	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	4'-phosphopantetheinyl transferase	8074379	3000948	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	4'-phosphopantetheinyl transferase	8074379	3000948	SCOP2B (2022-06-29)
C	SCOP2 Family	Holo-(acyl carrier protein) synthase ACPS	8074378	4003652	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	4'-phosphopantetheinyl transferase	8074379	3000948	SCOP2 (2022-06-29)
F	SCOP2B Superfamily	4'-phosphopantetheinyl transferase	8074379	3000948	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ACPS_1	e2wasA1	A: a+b three layers	X: Bacillus chorismate mutase-like	H: 4'-phosphopantetheinyl transferase (From Topology)	T: 4'-phosphopantetheinyl transferase	F: ACPS_1	ECOD (1.6)
E	ACPS_1	e2wasE1	A: a+b three layers	X: Bacillus chorismate mutase-like	H: 4'-phosphopantetheinyl transferase (From Topology)	T: 4'-phosphopantetheinyl transferase	F: ACPS_1	ECOD (1.6)
D	ACPS_1	e2wasD1	A: a+b three layers	X: Bacillus chorismate mutase-like	H: 4'-phosphopantetheinyl transferase (From Topology)	T: 4'-phosphopantetheinyl transferase	F: ACPS_1	ECOD (1.6)
B	ACPS_1	e2wasB1	A: a+b three layers	X: Bacillus chorismate mutase-like	H: 4'-phosphopantetheinyl transferase (From Topology)	T: 4'-phosphopantetheinyl transferase	F: ACPS_1	ECOD (1.6)
C	ACPS_1	e2wasC1	A: a+b three layers	X: Bacillus chorismate mutase-like	H: 4'-phosphopantetheinyl transferase (From Topology)	T: 4'-phosphopantetheinyl transferase	F: ACPS_1	ECOD (1.6)
F	ACPS_1	e2wasF1	A: a+b three layers	X: Bacillus chorismate mutase-like	H: 4'-phosphopantetheinyl transferase (From Topology)	T: 4'-phosphopantetheinyl transferase	F: ACPS_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.470.20	Alpha Beta	Alpha-Beta Complex	Ribosomal Protein L22	Chain A	CATH (4.3.0)
E	3.90.470.20	Alpha Beta	Alpha-Beta Complex	Ribosomal Protein L22	Chain A	CATH (4.3.0)
D	3.90.470.20	Alpha Beta	Alpha-Beta Complex	Ribosomal Protein L22	Chain A	CATH (4.3.0)
B	3.90.470.20	Alpha Beta	Alpha-Beta Complex	Ribosomal Protein L22	Chain A	CATH (4.3.0)
C	3.90.470.20	Alpha Beta	Alpha-Beta Complex	Ribosomal Protein L22	Chain A	CATH (4.3.0)
F	3.90.470.20	Alpha Beta	Alpha-Beta Complex	Ribosomal Protein L22	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D, E	PF01648	4'-phosphopantetheinyl transferase superfamily (ACPS)	4'-phosphopantetheinyl transferase superfamily	Members of this family transfers the 4'-phosphopantetheine (4'-PP) moiety from coenzyme A (CoA) to the invariant serine of Pfam:PF00550. This post-translational modification renders holo-ACP capable of acyl group activation via thioesterification of ...	Members of this family transfers the 4'-phosphopantetheine (4'-PP) moiety from coenzyme A (CoA) to the invariant serine of Pfam:PF00550. This post-translational modification renders holo-ACP capable of acyl group activation via thioesterification of the cysteamine thiol of 4'-PP [1]. This superfamily consists of two subtypes: The ACPS type such as Swiss:P24224 and the Sfp type such as Swiss:P39135. The structure of the Sfp type is known [3], which shows the active site accommodates a magnesium ion. The most highly conserved regions of the alignment are involved in binding the magnesium ion.	Domain
B, C, F	PF01648	4'-phosphopantetheinyl transferase superfamily (ACPS)	4'-phosphopantetheinyl transferase superfamily	Members of this family transfers the 4'-phosphopantetheine (4'-PP) moiety from coenzyme A (CoA) to the invariant serine of Pfam:PF00550. This post-translational modification renders holo-ACP capable of acyl group activation via thioesterification of ...	Members of this family transfers the 4'-phosphopantetheine (4'-PP) moiety from coenzyme A (CoA) to the invariant serine of Pfam:PF00550. This post-translational modification renders holo-ACP capable of acyl group activation via thioesterification of the cysteamine thiol of 4'-PP [1]. This superfamily consists of two subtypes: The ACPS type such as Swiss:P24224 and the Sfp type such as Swiss:P39135. The structure of the Sfp type is known [3], which shows the active site accommodates a magnesium ion. The most highly conserved regions of the alignment are involved in binding the magnesium ion.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D, E	3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE	holo-[acyl-carrier-protein] synthase activity transferase activity catalytic activity phosphotransferase activity, for other substituted phosphate groups transferase activity, transferring phosphorus-containing groups 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors acyltransferase activity 3-oxoacyl-[acyl-carrier-protein] synthase activity acyltransferase activity, transferring groups other than amino-acyl groups cation binding magnesium ion binding holo-[acyl-carrier-protein] synthase activity transferase activity catalytic activity phosphotransferase activity, for other substituted phosphate groups transferase activity, transferring phosphorus-containing groups 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors acyltransferase activity 3-oxoacyl-[acyl-carrier-protein] synthase activity acyltransferase activity, transferring groups other than amino-acyl groups cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding fatty-acyl-CoA synthase activity C-acyltransferase activity fatty acid synthase activity	fatty acid metabolic process long-chain fatty acid metabolic process monocarboxylic acid biosynthetic process oxoacid metabolic process small molecule biosynthetic process long-chain fatty acid biosynthetic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid metabolic process organic acid biosynthetic process fatty acid biosynthetic process carboxylic acid biosynthetic process biosynthetic process fatty acid metabolic process long-chain fatty acid metabolic process monocarboxylic acid biosynthetic process oxoacid metabolic process small molecule biosynthetic process long-chain fatty acid biosynthetic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid metabolic process organic acid biosynthetic process fatty acid biosynthetic process carboxylic acid biosynthetic process biosynthetic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process lipid metabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cytosol protein-containing complex catalytic complex fatty acid synthase complex intracellular protein-containing complex
B, C, F	3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE	holo-[acyl-carrier-protein] synthase activity transferase activity catalytic activity phosphotransferase activity, for other substituted phosphate groups transferase activity, transferring phosphorus-containing groups 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors acyltransferase activity 3-oxoacyl-[acyl-carrier-protein] synthase activity acyltransferase activity, transferring groups other than amino-acyl groups cation binding magnesium ion binding holo-[acyl-carrier-protein] synthase activity transferase activity catalytic activity phosphotransferase activity, for other substituted phosphate groups transferase activity, transferring phosphorus-containing groups 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors acyltransferase activity 3-oxoacyl-[acyl-carrier-protein] synthase activity acyltransferase activity, transferring groups other than amino-acyl groups cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding fatty-acyl-CoA synthase activity C-acyltransferase activity fatty acid synthase activity	fatty acid metabolic process long-chain fatty acid metabolic process monocarboxylic acid biosynthetic process oxoacid metabolic process small molecule biosynthetic process long-chain fatty acid biosynthetic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid metabolic process organic acid biosynthetic process fatty acid biosynthetic process carboxylic acid biosynthetic process biosynthetic process fatty acid metabolic process long-chain fatty acid metabolic process monocarboxylic acid biosynthetic process oxoacid metabolic process small molecule biosynthetic process long-chain fatty acid biosynthetic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid metabolic process organic acid biosynthetic process fatty acid biosynthetic process carboxylic acid biosynthetic process biosynthetic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process lipid metabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cytosol protein-containing complex catalytic complex fatty acid synthase complex intracellular protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D, E	IPR016035	Acyl transferase/acyl hydrolase/lysophospholipase	Homologous Superfamily
A, D, E	IPR014031	Beta-ketoacyl synthase, C-terminal	Domain
A, D, E	IPR002582	Holo-[acyl carrier protein] synthase	Family
A, D, E	IPR040899	Fatty acid synthase subunit alpha, acyl carrier domain	Domain
A, D, E	IPR037143	4'-phosphopantetheinyl transferase domain superfamily	Homologous Superfamily
A, D, E	IPR020841	Polyketide synthase, beta-ketoacyl synthase domain	Domain
A, D, E	IPR009081	Phosphopantetheine binding ACP domain	Domain
A, D, E	IPR041550	Fatty acid synthase type I, helical	Domain
A, D, E	IPR026025	Fatty acid synthase alpha subunit, yeast	Family
A, D, E	IPR008278	4'-phosphopantetheinyl transferase domain	Domain
A, D, E	IPR050830	Fungal fatty acid synthase	Family
A, D, E	IPR016039	Thiolase-like	Homologous Superfamily
A, D, E	IPR047224	Fatty acid synthase subunit alpha-like, C-terminal	Domain
A, D, E	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A, D, E	IPR018201	Beta-ketoacyl synthase, active site	Active Site
A, D, E	IPR014030	Beta-ketoacyl synthase-like, N-terminal	Domain
A, D, E	IPR004568	Phosphopantetheine-protein transferase domain	Domain
B, C, F	IPR016035	Acyl transferase/acyl hydrolase/lysophospholipase	Homologous Superfamily
B, C, F	IPR014031	Beta-ketoacyl synthase, C-terminal	Domain
B, C, F	IPR002582	Holo-[acyl carrier protein] synthase	Family
B, C, F	IPR040899	Fatty acid synthase subunit alpha, acyl carrier domain	Domain
B, C, F	IPR037143	4'-phosphopantetheinyl transferase domain superfamily	Homologous Superfamily
B, C, F	IPR020841	Polyketide synthase, beta-ketoacyl synthase domain	Domain
B, C, F	IPR009081	Phosphopantetheine binding ACP domain	Domain
B, C, F	IPR041550	Fatty acid synthase type I, helical	Domain
B, C, F	IPR026025	Fatty acid synthase alpha subunit, yeast	Family
B, C, F	IPR008278	4'-phosphopantetheinyl transferase domain	Domain
B, C, F	IPR050830	Fungal fatty acid synthase	Family
B, C, F	IPR016039	Thiolase-like	Homologous Superfamily
B, C, F	IPR047224	Fatty acid synthase subunit alpha-like, C-terminal	Domain
B, C, F	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
B, C, F	IPR018201	Beta-ketoacyl synthase, active site	Active Site
B, C, F	IPR014030	Beta-ketoacyl synthase-like, N-terminal	Domain
B, C, F	IPR004568	Phosphopantetheine-protein transferase domain	Domain