2Z5E | pdb_00002z5e

Crystal Structure of Proteasome Assembling Chaperone 3

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	PAC3-like	8051650	4007451	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Proteasome assembly chaperone-like	8053564	3002208	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Proteasome assembly chaperone-like	8053564	3002208	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PAC3	e2z5eA1	A: a+b two layers	X: Proteasome assembling chaperone 3 (PAC3)-related (From Topology)	H: Proteasome assembling chaperone 3 (PAC3)-related (From Topology)	T: Proteasome assembling chaperone 3 (PAC3)-related	F: PAC3	ECOD (1.6)
B	PAC3	e2z5eB1	A: a+b two layers	X: Proteasome assembling chaperone 3 (PAC3)-related (From Topology)	H: Proteasome assembling chaperone 3 (PAC3)-related (From Topology)	T: Proteasome assembling chaperone 3 (PAC3)-related	F: PAC3	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.230.90	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
B	3.30.230.90	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF10178	Proteasome assembly chaperone 3 (PAC3)	Proteasome assembly chaperone 3	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Proteasome Assembling Chaperone 3	molecular adaptor activity protein-containing complex binding binding	cellular component organization cellular component biogenesis cellular component assembly chaperone-mediated protein complex assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis proteasome assembly	protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR018788	Proteasome assembly chaperone 3	Family
A, B	IPR053720	Proteasome Assembly Chaperone	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9BT73	lung adenocarcinoma pancreatic intraductal papillary-mucinous carcinoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.