2ZJ1
Crystal structure of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with NAD and 3'-keto-aristeromycin
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
D | AdoHcyase_NAD | e2zj1D1 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: NAD(P)-binding Rossmann-fold domains | F: AdoHcyase_NAD | ECOD (1.6) |
D | AdoHcyase | e2zj1D2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: Formate/glycerate dehydrogenase catalytic domain-like | F: AdoHcyase | ECOD (1.6) |
A | AdoHcyase_NAD | e2zj1A1 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: NAD(P)-binding Rossmann-fold domains | F: AdoHcyase_NAD | ECOD (1.6) |
A | AdoHcyase | e2zj1A2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: Formate/glycerate dehydrogenase catalytic domain-like | F: AdoHcyase | ECOD (1.6) |
B | AdoHcyase_NAD | e2zj1B1 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: NAD(P)-binding Rossmann-fold domains | F: AdoHcyase_NAD | ECOD (1.6) |
B | AdoHcyase | e2zj1B2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: Formate/glycerate dehydrogenase catalytic domain-like | F: AdoHcyase | ECOD (1.6) |
C | AdoHcyase_NAD | e2zj1C1 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: NAD(P)-binding Rossmann-fold domains | F: AdoHcyase_NAD | ECOD (1.6) |
C | AdoHcyase | e2zj1C2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: Formate/glycerate dehydrogenase catalytic domain-like | F: AdoHcyase | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
D | 3.40.50.1480 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | Adenosylhomocysteinase-like | CATH (4.3.0) |
D | 3.40.50.720 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | NAD(P)-binding Rossmann-like Domain | CATH (4.3.0) |
A | 3.40.50.1480 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | Adenosylhomocysteinase-like | CATH (4.3.0) |
A | 3.40.50.720 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | NAD(P)-binding Rossmann-like Domain | CATH (4.3.0) |
B | 3.40.50.1480 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | Adenosylhomocysteinase-like | CATH (4.3.0) |
B | 3.40.50.720 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | NAD(P)-binding Rossmann-like Domain | CATH (4.3.0) |
C | 3.40.50.1480 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | Adenosylhomocysteinase-like | CATH (4.3.0) |
C | 3.40.50.720 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | NAD(P)-binding Rossmann-like Domain | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF05221 | S-adenosyl-L-homocysteine hydrolase (AdoHcyase) | S-adenosyl-L-homocysteine hydrolase | - | Domain | |
PF00670 | S-adenosyl-L-homocysteine hydrolase, NAD binding domain (AdoHcyase_NAD) | S-adenosyl-L-homocysteine hydrolase, NAD binding domain | - | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR000043 | Adenosylhomocysteinase-like | Family | |
IPR015878 | S-adenosyl-L-homocysteine hydrolase, NAD binding domain | Domain | |
IPR036291 | NAD(P)-binding domain superfamily | Homologous Superfamily | |
IPR020082 | S-adenosyl-L-homocysteine hydrolase, conserved site | Conserved Site | |
IPR042172 | Adenosylhomocysteinase-like superfamily | Homologous Superfamily |