2ZJ1

Crystal structure of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with NAD and 3'-keto-aristeromycin


Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
DAdoHcyase_NADe2zj1D1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: AdoHcyase_NADECOD (1.6)
DAdoHcyasee2zj1D2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: Formate/glycerate dehydrogenase catalytic domain-likeF: AdoHcyaseECOD (1.6)
AAdoHcyase_NADe2zj1A1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: AdoHcyase_NADECOD (1.6)
AAdoHcyasee2zj1A2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: Formate/glycerate dehydrogenase catalytic domain-likeF: AdoHcyaseECOD (1.6)
BAdoHcyase_NADe2zj1B1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: AdoHcyase_NADECOD (1.6)
BAdoHcyasee2zj1B2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: Formate/glycerate dehydrogenase catalytic domain-likeF: AdoHcyaseECOD (1.6)
CAdoHcyase_NADe2zj1C1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: AdoHcyase_NADECOD (1.6)
CAdoHcyasee2zj1C2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: Formate/glycerate dehydrogenase catalytic domain-likeF: AdoHcyaseECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D
PF05221S-adenosyl-L-homocysteine hydrolase (AdoHcyase)S-adenosyl-L-homocysteine hydrolase- Domain
A, B, C, D
PF00670S-adenosyl-L-homocysteine hydrolase, NAD binding domain (AdoHcyase_NAD)S-adenosyl-L-homocysteine hydrolase, NAD binding domain- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D
Adenosylhomocysteinase