2X1C | pdb_00002x1c

The crystal structure of precursor acyl coenzyme A:isopenicillin N acyltransferase from Penicillium chrysogenum

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	AAT	e2x1cA1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Penicillin acylase, catalytic domain	F: AAT	ECOD (1.6)
B	AAT	e2x1cB1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Penicillin acylase, catalytic domain	F: AAT	ECOD (1.6)
C	AAT	e2x1cC1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Penicillin acylase, catalytic domain	F: AAT	ECOD (1.6)
D	AAT	e2x1cD1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Penicillin acylase, catalytic domain	F: AAT	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.60.60.10	Alpha Beta	4-Layer Sandwich	Penicillin V Acylase	Chain A	CATH (4.3.0)
A	1.10.10.2120	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A		CATH (4.3.0)
B	3.60.60.10	Alpha Beta	4-Layer Sandwich	Penicillin V Acylase	Chain A	CATH (4.3.0)
B	1.10.10.2120	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A		CATH (4.3.0)
C	3.60.60.10	Alpha Beta	4-Layer Sandwich	Penicillin V Acylase	Chain A	CATH (4.3.0)
C	1.10.10.2120	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A		CATH (4.3.0)
D	3.60.60.10	Alpha Beta	4-Layer Sandwich	Penicillin V Acylase	Chain A	CATH (4.3.0)
D	1.10.10.2120	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF03417	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase (AAT)	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	ACYL-COENZYME	acyltransferase activity isopenicillin-N N-acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity N-acyltransferase activity	penicillin biosynthetic process oxoacid metabolic process organic acid metabolic process organic acid biosynthetic process carboxylic acid biosynthetic process secondary metabolic process antibiotic biosynthetic process antibiotic metabolic process secondary metabolite biosynthetic process sulfur compound metabolic process small molecule metabolic process amide metabolic process beta-lactam antibiotic metabolic process monocarboxylic acid biosynthetic process penicillin biosynthetic process oxoacid metabolic process organic acid metabolic process organic acid biosynthetic process carboxylic acid biosynthetic process secondary metabolic process antibiotic biosynthetic process antibiotic metabolic process secondary metabolite biosynthetic process sulfur compound metabolic process small molecule metabolic process amide metabolic process beta-lactam antibiotic metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process carboxylic acid metabolic process amide biosynthetic process lactam biosynthetic process lactam metabolic process amine metabolic process penicillin metabolic process sulfur compound biosynthetic process biosynthetic process metabolic process cellular process monocarboxylic acid metabolic process beta-lactam antibiotic biosynthetic process	peroxisomal matrix membrane-bounded organelle intracellular anatomical structure peroxisome membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle microbody lumen microbody cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR005079	Peptidase C45, hydrolase domain	Domain
A, B, C, D	IPR047794	Peptidase C45-like	Family
A, B, C, D	IPR047801	Peptidase C45	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.