3FOA | pdb_00003foa

Crystal structure of the bacteriophage T4 tail sheath protein, deletion mutant gp18M

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	18	e3foaA3	A: beta sandwiches	X: jelly-roll	H: Domain I of tail sheath protein Gp18 (From Topology)	T: Domain I of tail sheath protein Gp18	F: 18	ECOD (1.6)
A	Phage_sheath_1N_1	e3foaA2	A: a+b complex topology	X: Domain II in tail sheath protein Gp18 (From Topology)	H: Domain II in tail sheath protein Gp18 (From Topology)	T: Domain II in tail sheath protein Gp18	F: Phage_sheath_1N_1	ECOD (1.6)
A	Phage_sheath_1	e3foaA1	A: a/b three-layered sandwiches	X: Subtilisin-like	H: Domain III of tail sheath protein Gp18 (From Topology)	T: Domain III of tail sheath protein Gp18	F: Phage_sheath_1	ECOD (1.6)
B	18	e3foaB7	A: beta sandwiches	X: jelly-roll	H: Domain I of tail sheath protein Gp18 (From Topology)	T: Domain I of tail sheath protein Gp18	F: 18	ECOD (1.6)
B	Phage_sheath_1N_1	e3foaB9	A: a+b complex topology	X: Domain II in tail sheath protein Gp18 (From Topology)	H: Domain II in tail sheath protein Gp18 (From Topology)	T: Domain II in tail sheath protein Gp18	F: Phage_sheath_1N_1	ECOD (1.6)
B	Phage_sheath_1	e3foaB8	A: a/b three-layered sandwiches	X: Subtilisin-like	H: Domain III of tail sheath protein Gp18 (From Topology)	T: Domain III of tail sheath protein Gp18	F: Phage_sheath_1	ECOD (1.6)
C	18	e3foaC2	A: beta sandwiches	X: jelly-roll	H: Domain I of tail sheath protein Gp18 (From Topology)	T: Domain I of tail sheath protein Gp18	F: 18	ECOD (1.6)
C	Phage_sheath_1N_1	e3foaC5	A: a+b complex topology	X: Domain II in tail sheath protein Gp18 (From Topology)	H: Domain II in tail sheath protein Gp18 (From Topology)	T: Domain II in tail sheath protein Gp18	F: Phage_sheath_1N_1	ECOD (1.6)
C	Phage_sheath_1	e3foaC4	A: a/b three-layered sandwiches	X: Subtilisin-like	H: Domain III of tail sheath protein Gp18 (From Topology)	T: Domain III of tail sheath protein Gp18	F: Phage_sheath_1	ECOD (1.6)
D	18	e3foaD2	A: beta sandwiches	X: jelly-roll	H: Domain I of tail sheath protein Gp18 (From Topology)	T: Domain I of tail sheath protein Gp18	F: 18	ECOD (1.6)
D	Phage_sheath_1N_1	e3foaD5	A: a+b complex topology	X: Domain II in tail sheath protein Gp18 (From Topology)	H: Domain II in tail sheath protein Gp18 (From Topology)	T: Domain II in tail sheath protein Gp18	F: Phage_sheath_1N_1	ECOD (1.6)
D	Phage_sheath_1	e3foaD4	A: a/b three-layered sandwiches	X: Subtilisin-like	H: Domain III of tail sheath protein Gp18 (From Topology)	T: Domain III of tail sheath protein Gp18	F: Phage_sheath_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.11780	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
A	2.40.10.380	Mainly Beta	Beta Barrel	Thrombin, subunit H		CATH (4.3.0)
B	3.40.50.11780	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
B	2.40.10.380	Mainly Beta	Beta Barrel	Thrombin, subunit H		CATH (4.3.0)
C	3.40.50.11780	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
C	2.40.10.380	Mainly Beta	Beta Barrel	Thrombin, subunit H		CATH (4.3.0)
D	3.40.50.11780	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
D	2.40.10.380	Mainly Beta	Beta Barrel	Thrombin, subunit H		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF17481	Phage tail sheath protein beta-sandwich domain (Phage_sheath_domII)	Phage tail sheath protein beta-sandwich domain	This entry represents a two-layer beta sandwich domain found in a variety of phage tail sheath proteins, referred to as domain II in [4,5]. Domain I and II form the protease-resistant fragment [5].	Domain
A, B, C, D	PF22671	Tail sheath protein Gp18 domain III N-terminal region (Gp18_domIII_N)	Tail sheath protein Gp18 domain III N-terminal region	This entry represents the N-terminal segment of domain III from the phage tail sheath protein Gp18 y similar sequences [1-5]. Domain III is completed by Pfam:PF04984 with an overall structure consisting of a beta-sheet with five parallel and one anti ...	This entry represents the N-terminal segment of domain III from the phage tail sheath protein Gp18 y similar sequences [1-5]. Domain III is completed by Pfam:PF04984 with an overall structure consisting of a beta-sheet with five parallel and one anti-parallel beta-strands plus six alpha-helices, which surround the beta-sheet.	Domain
A, B, C, D	PF04984	Phage tail sheath protein subtilisin-like domain (Phage_sheath_1)	Phage tail sheath protein subtilisin-like domain	This entry represents the second domain in a variety of phage tail sheath proteins. According to ECOD this domain has a subtilisin-like structure.	Domain
A, B, C, D	PF22639	Tail sheath protein Gp18-like domain I (Gp18_dom_I)	Tail sheath protein Gp18-like domain I	This entry represents domain I from bacteriophage tail sheath proteins such as Gp18, a protein that surrounds the central non-contractile tail tube of the tail sheath from bacteriophages, which contracts during infection [1,2]. These proteins consist ...	This entry represents domain I from bacteriophage tail sheath proteins such as Gp18, a protein that surrounds the central non-contractile tail tube of the tail sheath from bacteriophages, which contracts during infection [1,2]. These proteins consist of three domains, domains I, II (Pfam:PF17481) and III (Pfam:PF17482). Domains I and II form the protease-resistant fragment [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Tail sheath protein Gp18	-	symbiont genome ejection through host cell envelope biological process involved in interspecies interaction between organisms symbiont entry into host cell viral process symbiont entry into host viral life cycle symbiont genome ejection through host cell envelope, contractile tail mechanism biological process involved in interaction with host biological process involved in symbiotic interaction	virus tail virion component virus tail, sheath

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR054565	Tail sheath protein Gp18-like, domain I	Domain
A, B, C, D	IPR020287	Tail sheath protein, C-terminal domain	Domain
A, B, C, D	IPR054564	Tail sheath protein Gp18-like, domain III N-terminal region	Domain
A, B, C, D	IPR035089	Tail sheath protein, subtilisin-like domain	Domain
A, B, C, D	IPR035326	Phage tail sheath protein-like, beta-sandwich domain	Domain
A, B, C, D	IPR052042	Bacteriophage Tail Sheath Structural Protein	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.