3K2M
Crystal Structure of Monobody HA4/Abl1 SH2 Domain Complex
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d3k2ma_ | Alpha and beta proteins (a+b) | SH2-like | SH2 domain | SH2 domain | automated matches | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
B | d3k2mb_ | Alpha and beta proteins (a+b) | SH2-like | SH2 domain | SH2 domain | automated matches | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
C | d3k2mc_ | All beta proteins | Immunoglobulin-like beta-sandwich | Fibronectin type III | automated matches | automated matches | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
D | d3k2md_ | All beta proteins | Immunoglobulin-like beta-sandwich | Fibronectin type III | automated matches | automated matches | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | SH2 | e3k2mA1 | A: a+b two layers | X: SH2 (From Topology) | H: SH2 (From Topology) | T: SH2 | F: SH2 | ECOD (1.6) |
B | SH2 | e3k2mB1 | A: a+b two layers | X: SH2 (From Topology) | H: SH2 (From Topology) | T: SH2 | F: SH2 | ECOD (1.6) |
C | fn3 | e3k2mC1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: fn3 | ECOD (1.6) |
D | fn3 | e3k2mD1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: fn3 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 3.30.505.10 | Alpha Beta | 2-Layer Sandwich | SHC Adaptor Protein | SH2 domain | CATH (4.3.0) |
B | 3.30.505.10 | Alpha Beta | 2-Layer Sandwich | SHC Adaptor Protein | SH2 domain | CATH (4.3.0) |
C | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
D | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
IMGT Antibody Annotation IMGT Database Homepage
Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
---|---|---|---|---|---|---|---|---|
ABL1 (Proto-oncogene tyrosine-protein kinase) | ABL1 | Homo sapiens (human) | ABL1*01 | R-LIKE-DOMAIN ABL1 (Pr121-232) | RPI | ABL1 | IMGT (202449-0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00017 | SH2 domain (SH2) | SH2 domain | - | Domain | |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR020635 | Tyrosine-protein kinase, catalytic domain | Domain | |
IPR000719 | Protein kinase domain | Domain | |
IPR017441 | Protein kinase, ATP binding site | Binding Site | |
IPR036860 | SH2 domain superfamily | Homologous Superfamily | |
IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain | Domain | |
IPR008266 | Tyrosine-protein kinase, active site | Active Site | |
IPR036028 | SH3-like domain superfamily | Homologous Superfamily | |
IPR001452 | SH3 domain | Domain | |
IPR035837 | Tyrosine-protein kinase ABL, SH2 domain | Domain | |
IPR000980 | SH2 domain | Domain | |
IPR015015 | F-actin binding | Domain | |
IPR011009 | Protein kinase-like domain superfamily | Homologous Superfamily | |
IPR050198 | Non-receptor tyrosine kinases involved in cell signaling | Family |