3MDY | pdb_00003mdy

Crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1B (BMPR1B) in complex with FKBP12 and LDN-193189


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilyProtein kinases catalytic domain-like 8080450 4003661 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyProtein kinase-like (PK-like) 8080451 3000066 SCOP2 (2022-06-29)
B [auth C]SCOP2B SuperfamilyProtein kinase-like (PK-like) 8080451 3000066 SCOP2B (2022-06-29)
C [auth B]SCOP2B SuperfamilyRotamase-like 8035974 3000622 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyRotamase-like 8035974 3000622 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APkinase_Tyre3mdyA1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Pkinase_TyrECOD (1.6)
B [auth C]Pkinase_Tyre3mdyC1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Pkinase_TyrECOD (1.6)
C [auth B]FKBP_Ce3mdyB1 A: a+b two layersX: FKBP-likeH: FKBP-likeT: FKBP-likeF: FKBP_CECOD (1.6)
DFKBP_Ce3mdyD1 A: a+b two layersX: FKBP-likeH: FKBP-likeT: FKBP-likeF: FKBP_CECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.30.200.20 Alpha Beta 2-Layer Sandwich Phosphorylase Kinase domain 1CATH (4.3.0)
A1.10.510.10 Mainly Alpha Orthogonal Bundle Transferase(Phosphotransferase) domain 1CATH (4.3.0)
B [auth C]3.30.200.20 Alpha Beta 2-Layer Sandwich Phosphorylase Kinase domain 1CATH (4.3.0)
B [auth C]1.10.510.10 Mainly Alpha Orthogonal Bundle Transferase(Phosphotransferase) domain 1CATH (4.3.0)
C [auth B]3.10.50.40 Alpha Beta Roll Chitinase A domain 3CATH (4.3.0)
D3.10.50.40 Alpha Beta Roll Chitinase A domain 3CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A,
B [auth C]
PF07714Protein tyrosine and serine/threonine kinase (PK_Tyr_Ser-Thr)Protein tyrosine and serine/threonine kinaseProtein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphospha ...Domain
A,
B [auth C]
PF08515Transforming growth factor beta type I GS-motif (TGF_beta_GS)Transforming growth factor beta type I GS-motif- Family
C [auth B],
D
PF00254FKBP-type peptidyl-prolyl cis-trans isomerase (FKBP_C)FKBP-type peptidyl-prolyl cis-trans isomeraseDomain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A,
B [auth C]
Bone morphogenetic protein receptor type-1B
C [auth B],
D
Peptidyl-prolyl cis-trans isomerase FKBP1A

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A,
B [auth C]
PharosO00238
C [auth B],
D
PharosP62942