3NQC
Crystal structure of the mutant I96S of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | d3nqcb_ | Alpha and beta proteins (a/b) | TIM beta/alpha-barrel | Ribulose-phoshate binding barrel | Decarboxylase | automated matches | (Methanothermobacter thermautotrophicus ) [TaxId: 145262 ], | SCOPe (2.08) |
A | d3nqca_ | Alpha and beta proteins (a/b) | TIM beta/alpha-barrel | Ribulose-phoshate binding barrel | Decarboxylase | automated matches | (Methanothermobacter thermautotrophicus ) [TaxId: 145262 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | OMPdecase | e3nqcB1 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: OMPdecase | ECOD (1.6) |
A | OMPdecase | e3nqcA1 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: OMPdecase | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
B | 3.20.20.70 | Alpha Beta | Alpha-Beta Barrel | TIM Barrel | Aldolase class I | CATH (4.3.0) |
A | 3.20.20.70 | Alpha Beta | Alpha-Beta Barrel | TIM Barrel | Aldolase class I | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00215 | Orotidine 5'-phosphate decarboxylase / HUMPS family (OMPdecase) | Orotidine 5'-phosphate decarboxylase / HUMPS family | This family includes Orotidine 5'-phosphate decarboxylase enzymes EC:4.1.1.23 that are involved in the final step of pyrimidine biosynthesis. The family also includes enzymes such as hexulose-6-phosphate synthase. This family appears to be distantly ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR047595 | Orotidine 5'-phosphate decarboxylase, archaeal | Family | |
IPR018089 | Orotidine 5'-phosphate decarboxylase, active site | Active Site | |
IPR011060 | Ribulose-phosphate binding barrel | Homologous Superfamily | |
IPR013785 | Aldolase-type TIM barrel | Homologous Superfamily | |
IPR001754 | Orotidine 5'-phosphate decarboxylase domain | Domain | |
IPR014732 | Orotidine 5'-phosphate decarboxylase | Family |