3OBV | pdb_00003obv

Autoinhibited Formin mDia1 Structure

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3obva_	All alpha proteins	alpha-alpha superhelix	ARM repeat	Diap1 N-terninal region-like	Diaphanous protein homolog 1, Diap1 (Dia1, DRF1)	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
C [auth B]	d3obvb_	All alpha proteins	alpha-alpha superhelix	ARM repeat	Diap1 N-terninal region-like	Diaphanous protein homolog 1, Diap1 (Dia1, DRF1)	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
E [auth C]	d3obvc_	All alpha proteins	alpha-alpha superhelix	ARM repeat	Diap1 N-terninal region-like	Diaphanous protein homolog 1, Diap1 (Dia1, DRF1)	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
G [auth D]	d3obvd_	All alpha proteins	alpha-alpha superhelix	ARM repeat	Diap1 N-terninal region-like	Diaphanous protein homolog 1, Diap1 (Dia1, DRF1)	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ARM repeat-like	8038395	3000116	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	ARM repeat-like	8038395	3000116	SCOP2B (2022-06-29)
E [auth C]	SCOP2B Superfamily	ARM repeat-like	8038395	3000116	SCOP2B (2022-06-29)
G [auth D]	SCOP2B Superfamily	ARM repeat-like	8038395	3000116	SCOP2B (2022-06-29)
B [auth E]	SCOP2B Superfamily	Formin homology 2 domain (FH2 domain)	8035646	3001266	SCOP2B (2022-06-29)
D [auth F]	SCOP2B Superfamily	Formin homology 2 domain (FH2 domain)	8035646	3001266	SCOP2B (2022-06-29)
F [auth G]	SCOP2B Superfamily	Formin homology 2 domain (FH2 domain)	8035646	3001266	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Formin homology 2 domain (FH2 domain)	8035646	3001266	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Drf_GBD	e3obvA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Drf_GBD	ECOD (1.6)
C [auth B]	Drf_GBD	e3obvB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Drf_GBD	ECOD (1.6)
E [auth C]	Drf_GBD	e3obvC1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Drf_GBD	ECOD (1.6)
G [auth D]	Drf_GBD	e3obvD1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Drf_GBD	ECOD (1.6)
B [auth E]	FH2	e3obvE1	A: alpha complex topology	X: Formin homology 2 domain (FH2 domain) (From Topology)	H: Formin homology 2 domain (FH2 domain) (From Topology)	T: Formin homology 2 domain (FH2 domain)	F: FH2	ECOD (1.6)
D [auth F]	FH2	e3obvF1	A: alpha complex topology	X: Formin homology 2 domain (FH2 domain) (From Topology)	H: Formin homology 2 domain (FH2 domain) (From Topology)	T: Formin homology 2 domain (FH2 domain)	F: FH2	ECOD (1.6)
F [auth G]	FH2	e3obvG1	A: alpha complex topology	X: Formin homology 2 domain (FH2 domain) (From Topology)	H: Formin homology 2 domain (FH2 domain) (From Topology)	T: Formin homology 2 domain (FH2 domain)	F: FH2	ECOD (1.6)
H	FH2	e3obvH1	A: alpha complex topology	X: Formin homology 2 domain (FH2 domain) (From Topology)	H: Formin homology 2 domain (FH2 domain) (From Topology)	T: Formin homology 2 domain (FH2 domain)	F: FH2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)
A	1.10.238.150	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
C [auth B]	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)
C [auth B]	1.10.238.150	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
E [auth C]	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)
E [auth C]	1.10.238.150	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
G [auth D]	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)
G [auth D]	1.10.238.150	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
B [auth E]	1.20.58.630	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
B [auth E]	1.20.58.2220	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
D [auth F]	1.20.58.630	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
D [auth F]	1.20.58.2220	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
F [auth G]	1.20.58.630	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
F [auth G]	1.20.58.2220	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
H	1.20.58.630	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
H	1.20.58.2220	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth B], E [auth C], G [auth D]	PF06371	Diaphanous GTPase-binding Domain (Drf_GBD)	Diaphanous GTPase-binding Domain	-	Repeat
A, C [auth B], E [auth C], G [auth D]	PF06367	Diaphanous FH3 Domain (Drf_FH3)	Diaphanous FH3 Domain	-	Repeat
B [auth E], D [auth F], F [auth G], H	PF02181	Formin Homology 2 Domain (FH2)	Formin Homology 2 Domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth B], E [auth C], G [auth D]	Protein diaphanous homolog 1	small GTPase binding protein binding binding enzyme binding GTPase binding profilin binding transmembrane transporter binding cytoskeletal protein binding actin binding identical protein binding	neuron recognition multicellular organismal process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development axon choice point recognition cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron recognition multicellular organismal process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development axon choice point recognition cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development cell recognition cellular component organization or biogenesis system development developmental process plasma membrane bounded cell projection organization axon midline choice point recognition axon guidance nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron projection guidance neuron development cellular process head development central nervous system development animal organ development brain development synaptic vesicle endocytosis import into cell cellular localization transport synaptic vesicle cycle establishment of localization vesicle-mediated transport presynaptic endocytosis vesicle-mediated transport in synapse synaptic vesicle recycling localization establishment of localization in cell endocytosis cellular response to stimulus regulation of neuron projection development regulation of cellular process regulation of cellular component organization regulation of developmental process response to stimulus regulation of cellular response to stress negative regulation of biological process negative regulation of neuron projection regeneration regeneration neuron projection regeneration cellular response to stress regulation of response to stress response to stress negative regulation of cellular process negative regulation of cell projection organization regulation of biological process negative regulation of cellular component organization negative regulation of response to stimulus regulation of cell projection organization negative regulation of developmental process biological regulation negative regulation of neuron projection development regulation of response to stimulus regulation of neuron projection regeneration regulation of plasma membrane bounded cell projection organization protein localization cellular macromolecule localization macromolecule localization organelle organization actin cytoskeleton organization actin filament organization actin filament-based process actin nucleation supramolecular fiber organization cytoskeleton organization cell surface receptor signaling pathway signaling cell surface receptor protein tyrosine kinase signaling pathway cell communication signal transduction enzyme-linked receptor protein signaling pathway ephrin receptor signaling pathway protein polymerization actin polymerization or depolymerization actin filament polymerization protein-containing complex organization cellular component biogenesis cellular component assembly protein-containing complex assembly regulation of cell shape regulation of cell morphogenesis regulation of biological quality regulation of anatomical structure morphogenesis biosynthetic process metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process neuron projection retraction neuron projection organization system process sensory perception nervous system process sensory perception of sound sensory perception of mechanical stimulus multicellular organismal locomotion multicellular organismal movement locomotion regulation of microtubule-based process microtubule-based process	ruffle cell leading edge plasma membrane membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection cellular anatomical structure ruffle membrane plasma membrane region cell projection membrane intracellular organelle centrosome ruffle cell leading edge plasma membrane membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection cellular anatomical structure ruffle membrane plasma membrane region cell projection membrane intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle microtubule cytoskeleton cluster of actin-based cell projections brush border presynapse synapse cell junction cytoplasm neuron projection spindle membrane-bounded organelle nucleus intracellular membrane-bounded organelle
B [auth E], D [auth F], F [auth G], H	Protein diaphanous homolog 1	small GTPase binding protein binding binding enzyme binding GTPase binding profilin binding transmembrane transporter binding cytoskeletal protein binding actin binding identical protein binding	neuron recognition multicellular organismal process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development axon choice point recognition cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron recognition multicellular organismal process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development axon choice point recognition cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development cell recognition cellular component organization or biogenesis system development developmental process plasma membrane bounded cell projection organization axon midline choice point recognition axon guidance nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron projection guidance neuron development cellular process head development central nervous system development animal organ development brain development synaptic vesicle endocytosis import into cell cellular localization transport synaptic vesicle cycle establishment of localization vesicle-mediated transport presynaptic endocytosis vesicle-mediated transport in synapse synaptic vesicle recycling localization establishment of localization in cell endocytosis cellular response to stimulus regulation of neuron projection development regulation of cellular process regulation of cellular component organization regulation of developmental process response to stimulus regulation of cellular response to stress negative regulation of biological process negative regulation of neuron projection regeneration regeneration neuron projection regeneration cellular response to stress regulation of response to stress response to stress negative regulation of cellular process negative regulation of cell projection organization regulation of biological process negative regulation of cellular component organization negative regulation of response to stimulus regulation of cell projection organization negative regulation of developmental process biological regulation negative regulation of neuron projection development regulation of response to stimulus regulation of neuron projection regeneration regulation of plasma membrane bounded cell projection organization protein localization cellular macromolecule localization macromolecule localization organelle organization actin cytoskeleton organization actin filament organization actin filament-based process actin nucleation supramolecular fiber organization cytoskeleton organization cell surface receptor signaling pathway signaling cell surface receptor protein tyrosine kinase signaling pathway cell communication signal transduction enzyme-linked receptor protein signaling pathway ephrin receptor signaling pathway protein polymerization actin polymerization or depolymerization actin filament polymerization protein-containing complex organization cellular component biogenesis cellular component assembly protein-containing complex assembly regulation of cell shape regulation of cell morphogenesis regulation of biological quality regulation of anatomical structure morphogenesis biosynthetic process metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process neuron projection retraction neuron projection organization system process sensory perception nervous system process sensory perception of sound sensory perception of mechanical stimulus multicellular organismal locomotion multicellular organismal movement locomotion regulation of microtubule-based process microtubule-based process	ruffle cell leading edge plasma membrane membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection cellular anatomical structure ruffle membrane plasma membrane region cell projection membrane intracellular organelle centrosome ruffle cell leading edge plasma membrane membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection cellular anatomical structure ruffle membrane plasma membrane region cell projection membrane intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle microtubule cytoskeleton cluster of actin-based cell projections brush border presynapse synapse cell junction cytoplasm neuron projection spindle membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth B], E [auth C], G [auth D]	IPR042201	Formin, FH2 domain superfamily	Homologous Superfamily
A, C [auth B], E [auth C], G [auth D]	IPR016024	Armadillo-type fold	Homologous Superfamily
A, C [auth B], E [auth C], G [auth D]	IPR015425	Formin, FH2 domain	Domain
A, C [auth B], E [auth C], G [auth D]	IPR011989	Armadillo-like helical	Homologous Superfamily
A, C [auth B], E [auth C], G [auth D]	IPR051412	Formin Homology Diaphanous subfamily	Family
A, C [auth B], E [auth C], G [auth D]	IPR014767	Diaphanous autoregulatory (DAD) domain	Domain
A, C [auth B], E [auth C], G [auth D]	IPR010472	Formin, FH3 domain	Domain
A, C [auth B], E [auth C], G [auth D]	IPR010473	Formin, GTPase-binding domain	Domain
A, C [auth B], E [auth C], G [auth D]	IPR014768	Rho GTPase-binding/formin homology 3 (GBD/FH3) domain	Domain
A, C [auth B], E [auth C], G [auth D]	IPR044933	Diaphanous, GTPase-binding domain superfamily	Homologous Superfamily
B [auth E], D [auth F], F [auth G], H	IPR042201	Formin, FH2 domain superfamily	Homologous Superfamily
B [auth E], D [auth F], F [auth G], H	IPR016024	Armadillo-type fold	Homologous Superfamily
B [auth E], D [auth F], F [auth G], H	IPR015425	Formin, FH2 domain	Domain
B [auth E], D [auth F], F [auth G], H	IPR011989	Armadillo-like helical	Homologous Superfamily
B [auth E], D [auth F], F [auth G], H	IPR051412	Formin Homology Diaphanous subfamily	Family
B [auth E], D [auth F], F [auth G], H	IPR014767	Diaphanous autoregulatory (DAD) domain	Domain
B [auth E], D [auth F], F [auth G], H	IPR010472	Formin, FH3 domain	Domain
B [auth E], D [auth F], F [auth G], H	IPR010473	Formin, GTPase-binding domain	Domain
B [auth E], D [auth F], F [auth G], H	IPR014768	Rho GTPase-binding/formin homology 3 (GBD/FH3) domain	Domain
B [auth E], D [auth F], F [auth G], H	IPR044933	Diaphanous, GTPase-binding domain superfamily	Homologous Superfamily