3URO | pdb_00003uro

Poliovirus receptor CD155 D1D2

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth R]	I-set_8	e3uroR1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_8	ECOD (1.6)
A [auth R]	V-set_15	e3uroR2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_15	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth R]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A [auth R]	PVR (Poliovirus receptor)	1V-1C-LIKE	Homo sapiens (human)	PVR	V-LIKE-DOMAIN V-LIKE, C-LIKE-DOMAIN C-LIKE	RPI	1V-1C-LIKE	IMGT (202510-0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth R]	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain
A [auth R]	PF08205	CD80-like C2-set immunoglobulin domain (C2-set_2)	CD80-like C2-set immunoglobulin domain	These domains belong to the immunoglobulin superfamily.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth R]	Poliovirus receptor	protein binding binding virus receptor activity exogenous protein binding molecular transducer activity signaling receptor activity molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity cell adhesion molecule binding	regulation of immune effector process lymphocyte mediated immunity positive regulation of leukocyte mediated immunity positive regulation of response to biotic stimulus regulation of cellular process response to stimulus response to biotic stimulus positive regulation of leukocyte mediated cytotoxicity positive regulation of immune response positive regulation of natural killer cell mediated immunity leukocyte mediated immunity regulation of immune system process natural killer cell mediated immunity positive regulation of immune system process regulation of immune effector process lymphocyte mediated immunity positive regulation of leukocyte mediated immunity positive regulation of response to biotic stimulus regulation of cellular process response to stimulus response to biotic stimulus positive regulation of leukocyte mediated cytotoxicity positive regulation of immune response positive regulation of natural killer cell mediated immunity leukocyte mediated immunity regulation of immune system process natural killer cell mediated immunity positive regulation of immune system process regulation of biological process regulation of natural killer cell mediated immunity immune response response to other organism regulation of innate immune response response to external stimulus leukocyte mediated cytotoxicity immune effector process regulation of leukocyte mediated immunity regulation of response to stimulus defense response to other organism positive regulation of defense response natural killer cell mediated cytotoxicity regulation of immune response positive regulation of natural killer cell mediated cytotoxicity regulation of cell killing positive regulation of cell killing regulation of defense response regulation of response to biotic stimulus regulation of natural killer cell mediated cytotoxicity biological process involved in interspecies interaction between organisms regulation of response to external stimulus positive regulation of lymphocyte mediated immunity positive regulation of biological process positive regulation of response to stimulus positive regulation of response to external stimulus regulation of response to stress response to stress innate immune response positive regulation of immune effector process response to external biotic stimulus positive regulation of cellular process positive regulation of innate immune response defense response regulation of leukocyte mediated cytotoxicity biological regulation defense response to symbiont regulation of lymphocyte mediated immunity immune system process cellular process cell killing adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains T cell mediated immunity positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of adaptive immune response susceptibility to T cell mediated cytotoxicity regulation of T cell mediated immunity T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity regulation of adaptive immune response adaptive immune response regulation of T cell mediated cytotoxicity positive regulation of T cell mediated immunity heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules cell adhesion cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules negative regulation of biological process negative regulation of lymphocyte mediated immunity negative regulation of natural killer cell mediated immunity negative regulation of immune response negative regulation of immune effector process negative regulation of response to external stimulus negative regulation of defense response negative regulation of natural killer cell mediated cytotoxicity negative regulation of response to biotic stimulus negative regulation of leukocyte mediated cytotoxicity negative regulation of cellular process negative regulation of cell killing negative regulation of response to stimulus negative regulation of immune system process negative regulation of leukocyte mediated immunity negative regulation of innate immune response homophilic cell adhesion via plasma membrane adhesion molecules positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target immune response to tumor cell regulation of natural killer cell mediated cytotoxicity directed against tumor cell target regulation of natural killer cell mediated immune response to tumor cell positive regulation of immune response to tumor cell natural killer cell mediated immune response to tumor cell positive regulation of response to tumor cell positive regulation of natural killer cell mediated immune response to tumor cell regulation of response to tumor cell response to tumor cell regulation of immune response to tumor cell natural killer cell mediated cytotoxicity directed against tumor cell target susceptibility to natural killer cell mediated cytotoxicity	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane cell surface cell periphery plasma membrane intracellular anatomical structure cytoplasm cell-cell junction adherens junction extracellular region cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction membrane cell surface cell periphery plasma membrane intracellular anatomical structure cytoplasm cell-cell junction adherens junction extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth R]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A [auth R]	IPR013106	Immunoglobulin V-set domain	Domain
A [auth R]	IPR003599	Immunoglobulin domain subtype	Domain
A [auth R]	IPR052659	Nectin and Poliovirus Receptor	Family
A [auth R]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A [auth R]	IPR013162	CD80-like, immunoglobulin C2-set	Domain
A [auth R]	IPR007110	Immunoglobulin-like domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth R]	Pharos: P15151	poliomyelitis Encephalitis, Polio malignant glioma osteosarcoma malignant mesothelioma polycystic ovary syndrome large cell medulloblastoma medulloblastoma psoriasis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.