3WSB

The Tuberculosis Drug SQ109 Inhibits Trypanosoma cruzi Cell Proliferation and acts Synergistically with Posaconazole

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3wsba_	All alpha proteins	Terpenoid synthases	Terpenoid synthases	automated matches	automated matches	(Trypanosoma cruzi strain CL Brener ) [TaxId: 353153 ],	SCOPe (2.08)
B	d3wsbb_	All alpha proteins	Terpenoid synthases	Terpenoid synthases	automated matches	automated matches	(Trypanosoma cruzi strain CL Brener ) [TaxId: 353153 ],	SCOPe (2.08)
C	d3wsbc_	All alpha proteins	Terpenoid synthases	Terpenoid synthases	automated matches	automated matches	(Trypanosoma cruzi strain CL Brener ) [TaxId: 353153 ],	SCOPe (2.08)
D	d3wsbd_	All alpha proteins	Terpenoid synthases	Terpenoid synthases	automated matches	automated matches	(Trypanosoma cruzi strain CL Brener ) [TaxId: 353153 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Terpenoid synthases	8080502	3001615	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Terpenoid synthases	8080502	3001615	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Terpenoid synthases	8080502	3001615	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Terpenoid synthases	8080502	3001615	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SQS_PSY	e3wsbA1	A: alpha bundles	X: Terpenoid synthases (From Topology)	H: Terpenoid synthases (From Topology)	T: Terpenoid synthases	F: SQS_PSY	ECOD (1.6)
B	SQS_PSY	e3wsbB1	A: alpha bundles	X: Terpenoid synthases (From Topology)	H: Terpenoid synthases (From Topology)	T: Terpenoid synthases	F: SQS_PSY	ECOD (1.6)
C	SQS_PSY	e3wsbC1	A: alpha bundles	X: Terpenoid synthases (From Topology)	H: Terpenoid synthases (From Topology)	T: Terpenoid synthases	F: SQS_PSY	ECOD (1.6)
D	SQS_PSY	e3wsbD1	A: alpha bundles	X: Terpenoid synthases (From Topology)	H: Terpenoid synthases (From Topology)	T: Terpenoid synthases	F: SQS_PSY	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.600.10	Mainly Alpha	Orthogonal Bundle	Farnesyl Diphosphate Synthase	Farnesyl Diphosphate Synthase	CATH (4.3.0)
B	1.10.600.10	Mainly Alpha	Orthogonal Bundle	Farnesyl Diphosphate Synthase	Farnesyl Diphosphate Synthase	CATH (4.3.0)
C	1.10.600.10	Mainly Alpha	Orthogonal Bundle	Farnesyl Diphosphate Synthase	Farnesyl Diphosphate Synthase	CATH (4.3.0)
D	1.10.600.10	Mainly Alpha	Orthogonal Bundle	Farnesyl Diphosphate Synthase	Farnesyl Diphosphate Synthase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00494	Squalene/phytoene synthase (SQS_PSY)	Squalene/phytoene synthase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Farnesyltransferase, putative	squalene synthase [NAD(P)H] activity prenyltransferase activity transferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups catalytic activity cation binding ion binding binding metal ion binding small molecule binding	primary metabolic process farnesyl diphosphate metabolic process phospholipid metabolic process organophosphate metabolic process phosphate-containing compound metabolic process metabolic process cellular process phosphorus metabolic process terpenoid metabolic process lipid metabolic process isoprenoid metabolic process biosynthetic process lipid biosynthetic process	membrane-bounded organelle intracellular anatomical structure organelle subcompartment membrane intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane membrane-bounded organelle intracellular anatomical structure organelle subcompartment membrane intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR033904	Trans-isoprenyl diphosphate synthases, head-to-head	Domain
A, B, C, D	IPR002060	Squalene/phytoene synthase	Family
A, B, C, D	IPR019845	Squalene/phytoene synthase, conserved site	Conserved Site
A, B, C, D	IPR008949	Isoprenoid synthase domain superfamily	Homologous Superfamily
A, B, C, D	IPR006449	Squalene synthase-like	Family
A, B, C, D	IPR044844	Trans-isoprenyl diphosphate synthases, eukaryotic-type	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.