4GZR | pdb_00004gzr

Crystal structure of the Mycobacterium tuberculosis H37Rv EsxOP (Rv2346c-Rv2347c) complex in space group C2221

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	UNK_F_TYPE	e4gzrA1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: ESAT-6 like (From Topology)	T: ESAT-6 like	F: UNK_F_TYPE	ECOD (1.6)
C	UNK_F_TYPE	e4gzrC1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: ESAT-6 like (From Topology)	T: ESAT-6 like	F: UNK_F_TYPE	ECOD (1.6)
D	WXG100_1st	e4gzrD3	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: ESAT-6 like (From Topology)	T: ESAT-6 like	F: WXG100_1st	ECOD (1.6)
B	WXG100_1st	e4gzrB1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: ESAT-6 like (From Topology)	T: ESAT-6 like	F: WXG100_1st	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.287.1060	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	ESAT-6-like	CATH (4.3.0)
C	1.10.287.1060	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	ESAT-6-like	CATH (4.3.0)
D	1.10.287.1060	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	ESAT-6-like	CATH (4.3.0)
B	1.10.287.1060	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	ESAT-6-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B, D	PF06013	Proteins of 100 residues with WXG (WXG100)	Proteins of 100 residues with WXG	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	ESAT-6-like protein 6	-	-	cell periphery cellular anatomical structure plasma membrane membrane external encapsulating structure cell wall peptidoglycan-based cell wall extracellular region
B, D	ESAT-6-like protein 7	-	-	cellular anatomical structure extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR036689	ESAT-6-like superfamily	Homologous Superfamily
A, C	IPR010310	Type VII secretion system ESAT-6-like	Family
A, C	IPR009416	ESAT-6-like protein, Mycobacterium	Family
B, D	IPR036689	ESAT-6-like superfamily	Homologous Superfamily
B, D	IPR010310	Type VII secretion system ESAT-6-like	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.