4J7G

Crystal structure of EvaA, a 2,3-dehydratase in complex with dTDP-fucose and dTDP-rhamnose

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Hexose_dehydrat	e4j7gB1	A: a+b two layers	X: beta-Grasp	H: Nudix (From Topology)	T: Nudix	F: Hexose_dehydrat	ECOD (1.6)
A	Hexose_dehydrat	e4j7gA1	A: a+b two layers	X: beta-Grasp	H: Nudix (From Topology)	T: Nudix	F: Hexose_dehydrat	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.90.79.40	Alpha Beta	Alpha-Beta Complex	Nucleoside Triphosphate Pyrophosphohydrolase	EvaA sugar 2,3-dehydratase subunit	CATH (4.3.0)
A	3.90.79.40	Alpha Beta	Alpha-Beta Complex	Nucleoside Triphosphate Pyrophosphohydrolase	EvaA sugar 2,3-dehydratase subunit	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF03559	NDP-hexose 2,3-dehydratase (Hexose_dehydrat)	NDP-hexose 2,3-dehydratase	This family includes a range of proteins from antibiotic production pathways. The family includes gra-ORF27 Swiss:Q9ZA32 product that probably functions at an early step, most likely as a dTDP-4-keto-6- deoxyglucose-2,3-dehydratase [1]. Its homologue ...	This family includes a range of proteins from antibiotic production pathways. The family includes gra-ORF27 Swiss:Q9ZA32 product that probably functions at an early step, most likely as a dTDP-4-keto-6- deoxyglucose-2,3-dehydratase [1]. Its homologues include dnmT from the daunorubicin biosynthetic gene cluster in S. peucetius [2], a similar gene from the daunomycin biosynthetic cluster in Streptomyces sp. strain C5 Swiss:Q53880 [3] , eryBVI from the erythromycin cluster in S. erythraea and snoH from the nogalamycin cluster in S. nogalater. The proteins in this family are composed of two copies of a 200 amino acid long unit that may be a structural domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	EvaA 2,3-dehydratase	lyase activity catalytic activity	antibiotic metabolic process biosynthetic process metabolic process cellular process antibiotic biosynthetic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR038153	dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase superfamily	Homologous Superfamily
A, B	IPR005212	dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.