4JD6

Crystal structure of Mycobacterium tuberculosis Eis in complex with coenzyme A and tobramycin

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	SCP2_2_C	e4jd6B5	A: a+b two layers	X: Sterol carrier protein-like	H: Sterol carrier protein, SCP-related (From Topology)	T: Sterol carrier protein, SCP-related	F: SCP2_2_C	ECOD (1.6)
B	Acetyltransf_1	e4jd6B7	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_1	ECOD (1.6)
B	SCP2_2_N	e4jd6B6	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: SCP2_2_N	ECOD (1.6)
C	SCP2_2_C	e4jd6C5	A: a+b two layers	X: Sterol carrier protein-like	H: Sterol carrier protein, SCP-related (From Topology)	T: Sterol carrier protein, SCP-related	F: SCP2_2_C	ECOD (1.6)
C	Acetyltransf_1	e4jd6C7	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_1	ECOD (1.6)
C	SCP2_2_N	e4jd6C6	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: SCP2_2_N	ECOD (1.6)
D	SCP2_2_C	e4jd6D5	A: a+b two layers	X: Sterol carrier protein-like	H: Sterol carrier protein, SCP-related (From Topology)	T: Sterol carrier protein, SCP-related	F: SCP2_2_C	ECOD (1.6)
D	Acetyltransf_1	e4jd6D7	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_1	ECOD (1.6)
D	SCP2_2_N	e4jd6D6	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: SCP2_2_N	ECOD (1.6)
E	SCP2_2_C	e4jd6E5	A: a+b two layers	X: Sterol carrier protein-like	H: Sterol carrier protein, SCP-related (From Topology)	T: Sterol carrier protein, SCP-related	F: SCP2_2_C	ECOD (1.6)
E	Acetyltransf_1	e4jd6E7	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_1	ECOD (1.6)
E	SCP2_2_N	e4jd6E6	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: SCP2_2_N	ECOD (1.6)
F	SCP2_2_C	e4jd6F5	A: a+b two layers	X: Sterol carrier protein-like	H: Sterol carrier protein, SCP-related (From Topology)	T: Sterol carrier protein, SCP-related	F: SCP2_2_C	ECOD (1.6)
F	Acetyltransf_1	e4jd6F7	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_1	ECOD (1.6)
F	SCP2_2_N	e4jd6F6	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: SCP2_2_N	ECOD (1.6)
A	SCP2_2_C	e4jd6A5	A: a+b two layers	X: Sterol carrier protein-like	H: Sterol carrier protein, SCP-related (From Topology)	T: Sterol carrier protein, SCP-related	F: SCP2_2_C	ECOD (1.6)
A	Acetyltransf_1	e4jd6A7	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_1	ECOD (1.6)
A	SCP2_2_N	e4jd6A6	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: SCP2_2_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)
B	3.30.1050.10	Alpha Beta	2-Layer Sandwich	Nonspecific Lipid-transfer Protein	Chain A	CATH (4.3.0)
C	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)
C	3.30.1050.10	Alpha Beta	2-Layer Sandwich	Nonspecific Lipid-transfer Protein	Chain A	CATH (4.3.0)
D	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)
D	3.30.1050.10	Alpha Beta	2-Layer Sandwich	Nonspecific Lipid-transfer Protein	Chain A	CATH (4.3.0)
E	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)
E	3.30.1050.10	Alpha Beta	2-Layer Sandwich	Nonspecific Lipid-transfer Protein	Chain A	CATH (4.3.0)
F	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)
F	3.30.1050.10	Alpha Beta	2-Layer Sandwich	Nonspecific Lipid-transfer Protein	Chain A	CATH (4.3.0)
A	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)
A	3.30.1050.10	Alpha Beta	2-Layer Sandwich	Nonspecific Lipid-transfer Protein	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF13527	Acetyltransferase (GNAT) domain (Acetyltransf_9)	Acetyltransferase (GNAT) domain	This domain catalyses N-acetyltransferase reactions.	Domain
A, B, C, D, E A, B, C, D, E, F	PF13530	Sterol carrier protein domain (SCP2_2)	Sterol carrier protein domain	-	Domain
A, B, C, D, E A, B, C, D, E, F	PF17668	Acetyltransferase (GNAT) domain (Acetyltransf_17)	Acetyltransferase (GNAT) domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Enhanced intracellular survival protein	acetyltransferase activity N-acetyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity N-acyltransferase activity peptide-lysine-N-acetyltransferase activity catalytic activity, acting on a protein peptide N-acetyltransferase activity aminoglycoside N-acetyltransferase activity identical protein binding protein binding binding	symbiont-mediated perturbation of host defense response symbiont-mediated perturbation of host defense-related programmed cell death symbiont-mediated perturbation of host cellular process response to host defenses biological process involved in interspecies interaction between organisms response to stimulus symbiont-mediated suppression of host defense-related programmed cell death symbiont-mediated perturbation of host programmed cell death response to other organism symbiont-mediated perturbation of host defenses response to defenses of other organism symbiont-mediated suppression of host programmed cell death response to external stimulus biological process involved in interaction with host response to biotic stimulus symbiont-mediated perturbation of host defense response symbiont-mediated perturbation of host defense-related programmed cell death symbiont-mediated perturbation of host cellular process response to host defenses biological process involved in interspecies interaction between organisms response to stimulus symbiont-mediated suppression of host defense-related programmed cell death symbiont-mediated perturbation of host programmed cell death response to other organism symbiont-mediated perturbation of host defenses response to defenses of other organism symbiont-mediated suppression of host programmed cell death response to external stimulus biological process involved in interaction with host response to biotic stimulus biological process involved in symbiotic interaction symbiont-mediated perturbation of host process symbiont-mediated suppression of host defenses response to host response to external biotic stimulus modulation of process of another organism carbohydrate derivative catabolic process glycosyl compound metabolic process catabolic process aminoglycoside antibiotic catabolic process glycoside metabolic process carbohydrate derivative metabolic process glycosyl compound catabolic process antibiotic catabolic process glycoside catabolic process antibiotic metabolic process aminoglycoside antibiotic metabolic process metabolic process cellular process response to chemical response to antibiotic symbiont-mediated perturbation of host inflammatory response cellular response to stimulus symbiont-mediated perturbation of host immune response cellular response to oxidative stress cellular response to chemical stress effector-mediated defense to host-produced reactive oxygen species response to oxidative stress cellular response to chemical stimulus cellular response to stress response to stress symbiont defense to host-produced reactive oxygen species symbiont-mediated perturbation of host innate immune response	membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle bacterial extracellular vesicle vesicle extracellular membrane-bounded organelle host extracellular space host cellular component intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle bacterial extracellular vesicle vesicle extracellular membrane-bounded organelle host extracellular space host cellular component intracellular anatomical structure cytoplasm cytosol host cell cytoplasmic vesicle host intracellular membrane-bounded organelle host intracellular part host cell cytoplasm host cell part host intracellular region host cell cytoplasm part host intracellular organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR025559	Enhanced intracellular survival protein domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR051554	Acetyltransferase Eis	Family
A, B, C, D, E A, B, C, D, E, F	IPR000182	GNAT domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR022902	N-acetyltransferase Eis	Family
A, B, C, D, E A, B, C, D, E, F	IPR016181	Acyl-CoA N-acyltransferase	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR036527	SCP2 sterol-binding domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR041380	Eis-like, acetyltransferase domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.