4JVH | pdb_00004jvh

Structure of the star domain of quaking protein in complex with RNA

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Homodimerisation domain of STAR proteins	8045751	4004659	SCOP2 (2022-06-29)
A	SCOP2 Family	Eukaryotic type KH-domain (KH-domain type I)	8052678	4001190	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Homodimerisation domain of STAR-like	8052679	3002134	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Eukaryotic type KH-domain (KH-domain type I)	8052680	3001023	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	STAR_dimer	e4jvhA1	A: alpha duplicates or obligate multimers	X: Qua1 (From Topology)	H: Qua1 (From Topology)	T: Qua1	F: STAR_dimer	ECOD (1.6)
A	KH_1	e4jvhA2	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: KH-domains	T: Eukaryotic type KH-domain (KH-domain type I)	F: KH_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.1370.10	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S8	Chain: A, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00013	KH domain (KH_1)	KH domain	KH motifs bind RNA in vitro. Autoantibodies to Nova, a KH domain protein, cause paraneoplastic opsoclonus ataxia.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Protein quaking	transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity mRNA 3'-UTR binding RNA binding binding nucleic acid binding mRNA binding regulatory RNA binding miRNA binding SH3 domain binding protein binding transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity mRNA 3'-UTR binding RNA binding binding nucleic acid binding mRNA binding regulatory RNA binding miRNA binding SH3 domain binding protein binding protein domain specific binding DNA binding protein-RNA adaptor activity internal N(7)-methylguanine-containing RNA reader activity	multicellular organismal process regulation of cellular process negative regulation of biological process negative regulation of type I interferon production cytokine production negative regulation of cellular process regulation of cytokine production regulation of multicellular organismal process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process type I interferon production negative regulation of metabolic process biological regulation multicellular organismal process regulation of cellular process negative regulation of biological process negative regulation of type I interferon production cytokine production negative regulation of cellular process regulation of cytokine production regulation of multicellular organismal process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process type I interferon production negative regulation of metabolic process biological regulation negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process negative regulation of multicellular organismal process regulation of metabolic process regulation of type I interferon production regulation of primary metabolic process post-transcriptional regulation of gene expression negative regulation of translation protein metabolic process negative regulation of protein metabolic process regulation of protein metabolic process primary metabolic process translation regulation of translation RNA transport nitrogen compound transport transport nucleic acid transport mRNA transport establishment of localization localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport positive regulation of biological process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of gene expression positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of leukocyte differentiation myeloid leukocyte differentiation cellular developmental process regulation of developmental process cell development regulation of cell differentiation mononuclear cell differentiation regulation of cell development multicellular organism development cell differentiation anatomical structure development regulation of immune system process negative regulation of cell differentiation negative regulation of macrophage differentiation regulation of macrophage differentiation negative regulation of hemopoiesis developmental process regulation of multicellular organismal development negative regulation of leukocyte differentiation hemopoiesis regulation of myeloid cell differentiation negative regulation of developmental process macrophage differentiation regulation of myeloid leukocyte differentiation negative regulation of myeloid cell differentiation negative regulation of myeloid leukocyte differentiation negative regulation of cell development myeloid cell differentiation negative regulation of immune system process immune system process regulation of hemopoiesis leukocyte differentiation regulation of steroid biosynthetic process regulation of cholesterol biosynthetic process regulation of cholesterol metabolic process steroid metabolic process regulation of lipid metabolic process sterol metabolic process cholesterol metabolic process lipid biosynthetic process alcohol metabolic process regulation of small molecule metabolic process positive regulation of lipid metabolic process small molecule metabolic process steroid biosynthetic process secondary alcohol biosynthetic process regulation of alcohol biosynthetic process small molecule biosynthetic process regulation of steroid metabolic process cholesterol biosynthetic process positive regulation of cholesterol biosynthetic process secondary alcohol metabolic process positive regulation of steroid biosynthetic process sterol biosynthetic process positive regulation of lipid biosynthetic process regulation of sterol biosynthetic process alcohol biosynthetic process positive regulation of cholesterol metabolic process positive regulation of steroid metabolic process regulation of lipid biosynthetic process positive regulation of small molecule metabolic process positive regulation of alcohol biosynthetic process positive regulation of sterol biosynthetic process lipid metabolic process regulation of epithelial to mesenchymal transition animal organ development mesenchyme development tissue development epithelial to mesenchymal transition mesenchymal cell differentiation astrocyte differentiation regulation of glial cell differentiation nervous system development regulation of astrocyte differentiation neurogenesis central nervous system development gliogenesis glial cell differentiation system development nucleobase-containing compound metabolic process regulation of RNA metabolic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological quality RNA catabolic process mRNA stabilization mRNA catabolic process nucleobase-containing compound catabolic process nucleic acid catabolic process negative regulation of RNA metabolic process catabolic process RNA metabolic process macromolecule catabolic process negative regulation of mRNA metabolic process regulation of mRNA catabolic process negative regulation of catabolic process negative regulation of mRNA catabolic process negative regulation of RNA catabolic process regulation of catabolic process mRNA metabolic process nucleic acid metabolic process regulation of mRNA stability RNA stabilization regulation of RNA stability regulation of mRNA metabolic process microglia differentiation positive regulation of nucleobase-containing compound metabolic process positive regulation of mRNA metabolic process negative regulation of 3'-UTR-mediated mRNA stabilization positive regulation of RNA metabolic process regulation of 3'-UTR-mediated mRNA stabilization 3'-UTR-mediated mRNA stabilization positive regulation of catabolic process positive regulation of mRNA catabolic process system process regulation of myelination regulation of system process regulation of nervous system development positive regulation of myelination axon ensheathment ensheathment of neurons positive regulation of nervous system process nervous system process regulation of nervous system process myelination positive regulation of multicellular organismal process spermatid development spermatid differentiation sexual reproduction spermatogenesis reproductive process multicellular organismal reproductive process cellular process involved in reproduction in multicellular organism developmental process involved in reproduction gamete generation male gamete generation germ cell development regulation of mRNA splicing, via spliceosome mRNA processing RNA biosynthetic process nucleic acid biosynthetic process RNA processing regulation of mRNA processing RNA splicing nucleobase-containing compound biosynthetic process regulation of RNA splicing RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile cellular localization cellular macromolecule localization intracellular mRNA localization actin filament-based process myofibroblast contraction actin-mediated cell contraction actin filament-based movement blood vessel morphogenesis tube development vasculogenesis vasculature development circulatory system development anatomical structure morphogenesis tube morphogenesis blood vessel development positive regulation of nervous system development regulation of neurogenesis regulation of gliogenesis positive regulation of gliogenesis positive regulation of developmental process positive regulation of cell differentiation positive regulation of neurogenesis positive regulation of oligodendrocyte differentiation positive regulation of cell development positive regulation of glial cell differentiation oligodendrocyte differentiation regulation of oligodendrocyte differentiation angiogenesis regulation of vasculature development regulation of anatomical structure morphogenesis negative regulation of blood vessel morphogenesis negative regulation of angiogenesis negative regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis fatty acid metabolic process long-chain fatty acid metabolic process monocarboxylic acid biosynthetic process oxoacid metabolic process long-chain fatty acid biosynthetic process carboxylic acid metabolic process organic acid metabolic process organic acid biosynthetic process fatty acid biosynthetic process carboxylic acid biosynthetic process monocarboxylic acid metabolic process smooth muscle cell differentiation muscle cell differentiation muscle structure development vascular associated smooth muscle cell differentiation negative regulation of cold-induced thermogenesis homeostatic process adaptive thermogenesis multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis negative regulation of miRNA catabolic process regulation of miRNA metabolic process miRNA metabolic process regulation of miRNA catabolic process miRNA catabolic process negative regulation of miRNA metabolic process spliceosome-depend formation of circular RNA	intracellular anatomical structure cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule intracellular organelle cellular anatomical structure organelle membraneless organelle cytoplasm supramolecular complex cytoplasmic stress granule cytosol synapse cell junction intracellular anatomical structure cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule intracellular organelle cellular anatomical structure organelle membraneless organelle cytoplasm supramolecular complex cytoplasmic stress granule cytosol synapse cell junction membrane-bounded organelle nucleus intracellular membrane-bounded organelle
B [auth D]	RNA (5'-R(UPUPCPAPCPUPAPAPCPAP*A)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR032367	Protein quaking, putative nuclear localisation signal	Domain
A	IPR032377	STAR protein, homodimerisation region	Domain
A	IPR004087	K Homology domain	Domain
A	IPR036612	K Homology domain, type 1 superfamily	Homologous Superfamily
A	IPR045071	KH domain-containing BBP-like	Family
A	IPR004088	K Homology domain, type 1	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q96PU8	malignant glioma mixed glioma lung carcinoma malignant ependymoma malignant pancreatic neoplasm myocardial infarction adenoma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma attention deficit hyperactivity disorder, inattentive type pilocytic astrocytoma colorectal cancer progressive supranuclear palsy ductal breast carcinoma in situ Sjogren syndrome malignant glioma mixed glioma lung carcinoma malignant ependymoma malignant pancreatic neoplasm myocardial infarction adenoma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma attention deficit hyperactivity disorder, inattentive type pilocytic astrocytoma colorectal cancer progressive supranuclear palsy ductal breast carcinoma in situ Sjogren syndrome glioma Unipolar Depression interstitial cystitis lung adenocarcinoma major depressive disorder medulloblastoma myopathy angiocentric glioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia atypical teratoid rhabdoid tumor plasma cell myeloma dermatomyositis rheumatoid arthritis gastric carcinoma subependymal giant cell astrocytoma hereditary spastic paraplegia invasive ductal breast carcinoma lung cancer malignant colon neoplasm malignant mesothelioma non-small cell lung carcinoma ovarian cancer astrocytic tumor Pick disease breast cancer primitive neuroectodermal tumor Down syndrome schizophrenia glioblastoma ulcerative colitis intellectual disability large cell medulloblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.