Annotations: 4K1N

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	alpha-Catenin/Vinculin-like	8036950	3001619	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	alpha-Catenin/Vinculin-like	8036950	3001619	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Vinculin_1st	e4k1nB1	A: alpha bundles	X: Four-helical up-and-down bundle	H: alpha-catenin-related	T: alpha-catenin/vinculin	F: Vinculin_1st	ECOD (1.6)
B	Vinculin_2nd	e4k1nB2	A: alpha bundles	X: Four-helical up-and-down bundle	H: alpha-catenin-related	T: alpha-catenin/vinculin	F: Vinculin_2nd	ECOD (1.6)
A	Vinculin_1st	e4k1nA3	A: alpha bundles	X: Four-helical up-and-down bundle	H: alpha-catenin-related	T: alpha-catenin/vinculin	F: Vinculin_1st	ECOD (1.6)
A	Vinculin_2nd	e4k1nA1	A: alpha bundles	X: Four-helical up-and-down bundle	H: alpha-catenin-related	T: alpha-catenin/vinculin	F: Vinculin_2nd	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Catenin alpha-1	gamma-catenin binding protein binding binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding vinculin binding cell adhesion molecule binding cadherin binding structural molecule activity beta-catenin binding identical protein binding	developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development system development neuroblast proliferation cell population proliferation cellular developmental process nervous system development generation of neurons neurogenesis cell differentiation cellular process neural precursor cell proliferation cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation smoothened signaling pathway cell communication signal transduction negative regulation of extrinsic apoptotic signaling pathway in absence of ligand signal transduction in absence of ligand negative regulation of signaling negative regulation of biological process regulation of signal transduction regulation of programmed cell death negative regulation of cell communication extrinsic apoptotic signaling pathway negative regulation of signal transduction in absence of ligand negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway negative regulation of cellular process extrinsic apoptotic signaling pathway in absence of ligand regulation of signaling negative regulation of response to stimulus negative regulation of programmed cell death regulation of apoptotic process cell death negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway negative regulation of apoptotic process regulation of response to stimulus regulation of extrinsic apoptotic signaling pathway in absence of ligand regulation of cell communication apoptotic process programmed cell death regulation of apoptotic signaling pathway response to hormone response to endogenous stimulus response to chemical response to estrogen protein localization localization cellular localization cellular macromolecule localization macromolecule localization cell adhesion cell-cell adhesion epithelial cell-cell adhesion regulation of integrin-mediated signaling pathway negative regulation of integrin-mediated signaling pathway integrin-mediated signaling pathway anatomical structure morphogenesis odontogenesis of dentin-containing tooth odontogenesis animal organ morphogenesis positive regulation of cell communication positive regulation of signal transduction positive regulation of biological process positive regulation of extrinsic apoptotic signaling pathway in absence of ligand positive regulation of apoptotic signaling pathway positive regulation of response to stimulus positive regulation of cellular process positive regulation of programmed cell death positive regulation of extrinsic apoptotic signaling pathway positive regulation of apoptotic process positive regulation of signaling negative regulation of neural precursor cell proliferation regulation of developmental process regulation of neuroblast proliferation cell development regulation of cell differentiation regulation of neurogenesis regulation of cell development negative regulation of neuroblast proliferation regulation of nervous system development negative regulation of neurogenesis negative regulation of nervous system development regulation of multicellular organismal process negative regulation of cell differentiation regulation of neural precursor cell proliferation negative regulation of cell population proliferation regulation of multicellular organismal development negative regulation of developmental process negative regulation of cell development regulation of cell population proliferation negative regulation of multicellular organismal process positive regulation of smoothened signaling pathway regulation of smoothened signaling pathway cellular component organization cellular component biogenesis cell junction organization cellular component assembly cell junction assembly cellular component organization or biogenesis apical junction assembly cell-cell junction assembly cell-cell junction organization negative regulation of locomotion regulation of cell motility regulation of locomotion negative regulation of cell motility cell motility locomotion female gonad development female sex differentiation development of primary female sexual characteristics ovarian follicle development gap junction assembly establishment or maintenance of cell polarity cell projection organization neuron projection development regeneration response to axon injury neuron projection regeneration axon regeneration neuron differentiation cellular response to stress response to stress response to wounding plasma membrane bounded cell projection organization axon development neuron development cellular response to nitrogen compound response to alcohol response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to alcohol response to indole-3-methanol cellular response to indole-3-methanol regulation of localization regulation of protein localization regulation of protein localization to nucleus protein localization to nucleus negative regulation of protein localization to nucleus regulation of cellular localization protein localization to organelle negative regulation of protein localization	cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium intracellular organelle intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cell periphery plasma membrane cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium intracellular organelle intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cell periphery plasma membrane membrane protein-containing complex extrinsic component of plasma membrane catenin complex plasma membrane protein complex membrane protein complex extrinsic component of membrane cell-cell junction apical junction complex adherens junction anchoring junction cell junction zonula adherens membrane raft plasma membrane raft caveola membrane microdomain flotillin complex plasma membrane region intercalated disc cell-cell contact zone membrane-bounded organelle nucleus intracellular membrane-bounded organelle acrosomal vesicle intracellular vesicle endomembrane system cytoplasmic vesicle secretory granule secretory vesicle cytoplasm vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR001033	Alpha-catenin	Family
A, B	IPR036723	Alpha-catenin/vinculin-like superfamily	Homologous Superfamily
A, B	IPR006077	Vinculin/alpha-catenin	Family
A, B	IPR000633	Vinculin, conserved site	Conserved Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.