4K1O | pdb_00004k1o

Crystal structure of the alphaN-catenin actin-binding domain

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Vinculin_2nd	e4k1oA1	A: alpha bundles	X: Four-helical up-and-down bundle	H: alpha-catenin-related	T: alpha-catenin/vinculin	F: Vinculin_2nd	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.120.230	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Alpha-catenin/vinculin-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01044	Vinculin family (Vinculin)	Vinculin family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Catenin alpha-2	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding cell adhesion molecule binding cadherin binding structural molecule activity identical protein binding	regulation of biological process regulation of cellular component organization regulation of cellular process regulation of synapse structural plasticity biological regulation cellular component organization regulation of synapse organization cell junction organization cellular process regulation of synapse structure or activity synapse organization cellular component organization or biogenesis regulation of biological quality developmental process regulation of biological process regulation of cellular component organization regulation of cellular process regulation of synapse structural plasticity biological regulation cellular component organization regulation of synapse organization cell junction organization cellular process regulation of synapse structure or activity synapse organization cellular component organization or biogenesis regulation of biological quality developmental process multicellular organismal process head development brain morphogenesis animal organ development brain development nervous system development multicellular organism development anatomical structure morphogenesis central nervous system development anatomical structure development animal organ morphogenesis system development cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis cell projection morphogenesis neuron differentiation neuron projection morphogenesis dendrite development cell differentiation plasma membrane bounded cell projection organization dendrite morphogenesis cell morphogenesis involved in neuron differentiation generation of neurons neuron development regulation of cell motility neuron migration regulation of neuron migration regulation of locomotion regulation of cell migration cell migration cell motility locomotion axonogenesis axon development radial glia guided migration of Purkinje cell hindbrain radial glia guided cell migration hindbrain development cell migration in hindbrain modification of postsynaptic actin cytoskeleton modification of postsynaptic structure modification of synaptic structure startle response system process response to stimulus nervous system process regulation of response to external stimulus neuromuscular process negative regulation of response to stimulus negative regulation of biological process prepulse inhibition response to external stimulus regulation of response to stimulus negative regulation of response to external stimulus regulation of Arp2/3 complex-mediated actin nucleation regulation of cytoskeleton organization regulation of actin filament-based process regulation of actin nucleation actin filament-based process negative regulation of cellular process negative regulation of supramolecular fiber organization negative regulation of actin nucleation negative regulation of Arp2/3 complex-mediated actin nucleation regulation of actin filament organization actin cytoskeleton organization negative regulation of cellular component organization negative regulation of cytoskeleton organization actin filament organization Arp2/3 complex-mediated actin nucleation regulation of organelle organization organelle organization negative regulation of organelle organization regulation of actin cytoskeleton organization regulation of supramolecular fiber organization actin nucleation supramolecular fiber organization cytoskeleton organization cell adhesion cell-cell adhesion regulation of neuron projection development regulation of cell projection organization regulation of plasma membrane bounded cell projection organization	cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium intracellular organelle intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton extrinsic component of plasma membrane synapse cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium intracellular organelle intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton extrinsic component of plasma membrane synapse membrane plasma membrane synaptic membrane cell periphery extrinsic component of synaptic membrane postsynapse postsynaptic membrane cell junction plasma membrane region extrinsic component of membrane extrinsic component of postsynaptic membrane parallel fiber to Purkinje cell synapse excitatory synapse basal part of cell basal plasma membrane basolateral plasma membrane cell cortex cytoplasmic region presynaptic active zone cytoplasmic component presynapse cell cortex region cytoplasm presynaptic active zone cell-cell junction adherens junction anchoring junction neuron to neuron synapse hippocampal mossy fiber to CA3 synapse presynaptic membrane extrinsic component of presynaptic membrane postsynaptic density postsynaptic specialization asymmetric synapse postsynaptic density, intracellular component postsynaptic specialization, intracellular component axon neuron projection membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001033	Alpha-catenin	Family
A	IPR036723	Alpha-catenin/vinculin-like superfamily	Homologous Superfamily
A	IPR006077	Vinculin/alpha-catenin	Family
A	IPR000633	Vinculin, conserved site	Conserved Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.