4KN2

Human folate receptor beta (FOLR2) in complex with antifolate pemetrexed

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Frizzled domain-like	8090922	3001950	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Frizzled domain-like	8090922	3001950	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Frizzled domain-like	8090922	3001950	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Folate_rec	e4kn2B1	A: few secondary structure elements	X: Frizzled cysteine-rich domain-related (From Topology)	H: Frizzled cysteine-rich domain-related (From Topology)	T: Frizzled cysteine-rich domain-related	F: Folate_rec	ECOD (1.6)
C	Folate_rec	e4kn2C1	A: few secondary structure elements	X: Frizzled cysteine-rich domain-related (From Topology)	H: Frizzled cysteine-rich domain-related (From Topology)	T: Frizzled cysteine-rich domain-related	F: Folate_rec	ECOD (1.6)
A	Folate_rec	e4kn2A1	A: few secondary structure elements	X: Frizzled cysteine-rich domain-related (From Topology)	H: Frizzled cysteine-rich domain-related (From Topology)	T: Frizzled cysteine-rich domain-related	F: Folate_rec	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF03024	Folate receptor family (Folate_rec)	Folate receptor family	This family includes the folate receptor which binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. These proteins are attached to the membrane by a GPI-anchor. The proteins co ...	This family includes the folate receptor which binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. These proteins are attached to the membrane by a GPI-anchor. The proteins contain 16 conserved cysteines that form eight disulphide bridges.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Folate receptor beta	molecular transducer activity signaling receptor activity amide binding organic acid binding binding modified amino acid binding vitamin binding ion binding organic cyclic compound binding folic acid binding anion binding carboxylic acid binding heterocyclic compound binding small molecule binding molecular transducer activity signaling receptor activity amide binding organic acid binding binding modified amino acid binding vitamin binding ion binding organic cyclic compound binding folic acid binding anion binding carboxylic acid binding heterocyclic compound binding small molecule binding cargo receptor activity folic acid receptor activity	regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process cellular process positive regulation of cellular process membrane organization sexual reproduction membrane fusion reproductive process plasma membrane fusion regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process cellular process positive regulation of cellular process membrane organization sexual reproduction membrane fusion reproductive process plasma membrane fusion fertilization multicellular organismal reproductive process cellular process involved in reproduction in multicellular organism cellular component organization fusion of sperm to egg plasma membrane involved in single fertilization plasma membrane organization cellular component organization or biogenesis endomembrane system organization single fertilization sperm-egg recognition cell-cell recognition cell recognition cell adhesion response to stimulus defense response response to stress inflammatory response organic anion transport nitrogen compound transport carboxylic acid transport transport vitamin transport establishment of localization organic acid transport localization amide transport folic acid transport dicarboxylic acid transport modified amino acid transport	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR004269	Folate receptor	Family
A, B, C	IPR018143	Folate receptor-like	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: P14207	neural tube defect Liver Cirrhosis, Experimental mycosis fungoides neurenteric cyst pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriatic arthritis bone osteosarcoma tuberculosis ductal breast carcinoma in situ gestational trophoblastic neoplasm invasive ductal breast carcinoma acute lymphoblastic leukemia breast carcinoma craniorachischisis iniencephaly neural tube defect Liver Cirrhosis, Experimental mycosis fungoides neurenteric cyst pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriatic arthritis bone osteosarcoma tuberculosis ductal breast carcinoma in situ gestational trophoblastic neoplasm invasive ductal breast carcinoma acute lymphoblastic leukemia breast carcinoma craniorachischisis iniencephaly juvenile idiopathic arthritis malignant pleural mesothelioma non-small cell lung carcinoma psoriasis adrenal cortex carcinoma rheumatoid arthritis Burkitt lymphoma tethered spinal cord syndrome diastematomyelia interstitial cystitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.