4OTB | pdb_00004otb

4-OXALOCROTONATE TAUTOMERASE OBSERVED AS AN OCTODECAMER, RHOMBOHEDRAL CRYSTAL FORM

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4otba_	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	4-oxalocrotonate tautomerase-like	4-oxalocrotonate tautomerase	(Pseudomonas putida ) [TaxId: 303 ],	SCOPe (2.08)
B	d4otbb_	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	4-oxalocrotonate tautomerase-like	4-oxalocrotonate tautomerase	(Pseudomonas putida ) [TaxId: 303 ],	SCOPe (2.08)
C	d4otbc_	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	4-oxalocrotonate tautomerase-like	4-oxalocrotonate tautomerase	(Pseudomonas putida ) [TaxId: 303 ],	SCOPe (2.08)
D	d4otbd_	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	4-oxalocrotonate tautomerase-like	4-oxalocrotonate tautomerase	(Pseudomonas putida ) [TaxId: 303 ],	SCOPe (2.08)
E	d4otbe_	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	4-oxalocrotonate tautomerase-like	4-oxalocrotonate tautomerase	(Pseudomonas putida ) [TaxId: 303 ],	SCOPe (2.08)
F	d4otbf_	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	4-oxalocrotonate tautomerase-like	4-oxalocrotonate tautomerase	(Pseudomonas putida ) [TaxId: 303 ],	SCOPe (2.08)
G	d4otbg_	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	4-oxalocrotonate tautomerase-like	4-oxalocrotonate tautomerase	(Pseudomonas putida ) [TaxId: 303 ],	SCOPe (2.08)
H	d4otbh_	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	4-oxalocrotonate tautomerase-like	4-oxalocrotonate tautomerase	(Pseudomonas putida ) [TaxId: 303 ],	SCOPe (2.08)
I	d4otbi_	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	4-oxalocrotonate tautomerase-like	4-oxalocrotonate tautomerase	(Pseudomonas putida ) [TaxId: 303 ],	SCOPe (2.08)
J	d4otbj_	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	4-oxalocrotonate tautomerase-like	4-oxalocrotonate tautomerase	(Pseudomonas putida ) [TaxId: 303 ],	SCOPe (2.08)
K	d4otbk_	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	4-oxalocrotonate tautomerase-like	4-oxalocrotonate tautomerase	(Pseudomonas putida ) [TaxId: 303 ],	SCOPe (2.08)
L	d4otbl_	Alpha and beta proteins (a+b)	Tautomerase/MIF	Tautomerase/MIF	4-oxalocrotonate tautomerase-like	4-oxalocrotonate tautomerase	(Pseudomonas putida ) [TaxId: 303 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Tautomerase/MIF	8036048	3001770	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Tautomerase/MIF	8036048	3001770	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Tautomerase/MIF	8036048	3001770	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Tautomerase/MIF	8036048	3001770	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Tautomerase/MIF	8036048	3001770	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Tautomerase/MIF	8036048	3001770	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Tautomerase/MIF	8036048	3001770	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Tautomerase/MIF	8036048	3001770	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Tautomerase/MIF	8036048	3001770	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Tautomerase/MIF	8036048	3001770	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Tautomerase/MIF	8036048	3001770	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Tautomerase/MIF	8036048	3001770	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Tautomerase_2	e4otbA1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: Tautomerase_2	ECOD (1.6)
B	Tautomerase_2	e4otbB1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: Tautomerase_2	ECOD (1.6)
C	Tautomerase_2	e4otbC1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: Tautomerase_2	ECOD (1.6)
D	Tautomerase_2	e4otbD1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: Tautomerase_2	ECOD (1.6)
E	Tautomerase_2	e4otbE1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: Tautomerase_2	ECOD (1.6)
F	Tautomerase_2	e4otbF1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: Tautomerase_2	ECOD (1.6)
G	Tautomerase_2	e4otbG1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: Tautomerase_2	ECOD (1.6)
H	Tautomerase_2	e4otbH1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: Tautomerase_2	ECOD (1.6)
I	Tautomerase_2	e4otbI1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: Tautomerase_2	ECOD (1.6)
J	Tautomerase_2	e4otbJ1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: Tautomerase_2	ECOD (1.6)
K	Tautomerase_2	e4otbK1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: Tautomerase_2	ECOD (1.6)
L	Tautomerase_2	e4otbL1	A: a+b two layers	X: Tautomerase/MIF-like	H: Tautomerase/MIF (From Topology)	T: Tautomerase/MIF	F: Tautomerase_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (4.3.0)
B	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (4.3.0)
C	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (4.3.0)
D	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (4.3.0)
E	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (4.3.0)
F	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (4.3.0)
G	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (4.3.0)
H	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (4.3.0)
I	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (4.3.0)
J	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (4.3.0)
K	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (4.3.0)
L	3.30.429.10	Alpha Beta	2-Layer Sandwich	Macrophage Migration Inhibitory Factor	Macrophage Migration Inhibitory Factor	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF01361	Tautomerase enzyme (Tautomerase)	Tautomerase enzyme	This family includes the enzyme 4-oxalocrotonate tautomerase Swiss:Q01468 that catalyses the ketonisation of 2-hydroxymuconate to 2-oxo-3-hexenedioate.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	4-OXALOCROTONATE TAUTOMERASE	isomerase activity catalytic activity	cellular response to stimulus catabolic process benzene-containing compound metabolic process response to stimulus hydrocarbon catabolic process cellular response to xenobiotic stimulus toluene-containing compound metabolic process xenobiotic catabolic process hydrocarbon metabolic process xenobiotic metabolic process response to xenobiotic stimulus cellular response to chemical stimulus response to chemical toluene catabolic process cellular response to stimulus catabolic process benzene-containing compound metabolic process response to stimulus hydrocarbon catabolic process cellular response to xenobiotic stimulus toluene-containing compound metabolic process xenobiotic catabolic process hydrocarbon metabolic process xenobiotic metabolic process response to xenobiotic stimulus cellular response to chemical stimulus response to chemical toluene catabolic process metabolic process cellular process toluene metabolic process toluene-containing compound catabolic process xylene catabolic process xylene metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR014347	Tautomerase/MIF superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR004370	4-oxalocrotonate tautomerase-like domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR018191	4-oxalocrotonate tautomerase	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.