Annotations: 4X1J

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DAN	e4x1jA1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: DAN	ECOD (1.6)
B	DAN	e4x1jB1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: DAN	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.10.90.10	Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Neuroblastoma suppressor of tumorigenicity 1	molecular transducer activity protein binding binding molecular function activator activity signaling receptor binding signaling receptor activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity morphogen activity BMP binding cytokine binding identical protein binding	multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process positive regulation of biological process regulation of cell differentiation positive regulation of neuron differentiation positive regulation of developmental process neurogenesis multicellular organism development neuron differentiation positive regulation of cell differentiation cell differentiation anatomical structure development multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process positive regulation of biological process regulation of cell differentiation positive regulation of neuron differentiation positive regulation of developmental process neurogenesis multicellular organism development neuron differentiation positive regulation of cell differentiation cell differentiation anatomical structure development positive regulation of cellular process system development developmental process regulation of biological process biological regulation nervous system development generation of neurons cellular process regulation of neuron differentiation cellular response to stimulus negative regulation of mononuclear cell migration negative regulation of locomotion negative regulation of leukocyte chemotaxis regulation of cell motility response to stimulus regulation of response to external stimulus negative regulation of biological process negative regulation of chemotaxis negative regulation of monocyte chemotaxis regulation of monocyte chemotaxis taxis negative regulation of cellular process regulation of cell migration myeloid leukocyte migration cell migration regulation of immune system process cell motility regulation of mononuclear cell migration negative regulation of cell migration locomotion cell chemotaxis chemotaxis regulation of leukocyte chemotaxis negative regulation of response to stimulus regulation of leukocyte migration response to external stimulus regulation of chemotaxis monocyte chemotaxis leukocyte migration cellular response to chemical stimulus negative regulation of leukocyte migration negative regulation of immune system process regulation of response to stimulus immune system process regulation of locomotion response to chemical negative regulation of response to external stimulus mononuclear cell migration negative regulation of cell motility leukocyte chemotaxis cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus signaling negative regulation of signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of signal transduction negative regulation of cellular response to growth factor stimulus negative regulation of BMP signaling pathway negative regulation of cell communication cell communication cellular response to endogenous stimulus extracellular negative regulation of signal transduction signal transduction BMP signaling pathway enzyme-linked receptor protein signaling pathway cellular response to BMP stimulus regulation of signaling cell surface receptor signaling pathway regulation of BMP signaling pathway response to endogenous stimulus regulation of cellular response to growth factor stimulus negative regulation of signal transduction response to BMP sequestering of BMP from receptor via BMP binding regulation of cell communication transforming growth factor beta receptor superfamily signaling pathway response to growth factor negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway sequestering of extracellular ligand from receptor extracellular regulation of signal transduction protein localization localization cellular macromolecule localization maintenance of location sequestering of BMP in extracellular matrix maintenance of protein location in extracellular region maintenance of protein location cellular localization protein localization to extracellular region macromolecule localization cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization cell projection morphogenesis neuron projection morphogenesis cellular component organization or biogenesis plasma membrane bounded cell projection organization anatomical structure morphogenesis neuron development pattern specification process regionalization dorsal/ventral pattern formation determination of bilateral symmetry determination of dorsal/ventral asymmetry determination of dorsal identity specification of symmetry	cellular anatomical structure extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR016728	Neuroblastoma suppressor of tumourigenicity 1	Family
A, B	IPR029034	Cystine-knot cytokine	Homologous Superfamily
A, B	IPR006207	Cystine knot, C-terminal	Domain
A, B	IPR004133	DAN	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P41271	hyperthyroidism hypothyroidism

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.