4ZJ7 | pdb_00004zj7

Crystal structure of the karyopherin Kap121p bound to the extreme C-terminus of the protein phosphatase Cdc14p

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	IBN_N	e4zj7A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: IBN_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	6.10.140.1700	Special	Helix non-globular	Helix Hairpins		CATH (4.3.0)
A	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF18829	Importin repeat 6 (Importin_rep_6)	Importin repeat 6	-	Repeat
A	PF18808	Importin repeat (Importin_rep_4)	Importin repeat	-	Repeat
A	PF18816	Importin repeat (Importin_rep_5)	Importin repeat	-	Repeat
A	PF13513	HEAT-like repeat (HEAT_EZ)	HEAT-like repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Importin subunit beta-3	nuclear import signal receptor activity nucleocytoplasmic carrier activity molecular carrier activity nuclear localization sequence binding signal sequence binding binding peptide binding	regulation of cellular process regulation of protein modification process peptidyl-lysine modification protein desumoylation regulation of primary metabolic process protein modification by small protein removal peptidyl-amino acid modification protein metabolic process regulation of protein modification by small protein conjugation or removal protein modification process regulation of biological process regulation of post-translational protein modification regulation of protein metabolic process biological regulation regulation of cellular process regulation of protein modification process peptidyl-lysine modification protein desumoylation regulation of primary metabolic process protein modification by small protein removal peptidyl-amino acid modification protein metabolic process regulation of protein modification by small protein conjugation or removal protein modification process regulation of biological process regulation of post-translational protein modification regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process macromolecule modification metabolic process cellular process macromolecule metabolic process post-translational protein modification regulation of metabolic process protein modification by small protein conjugation or removal regulation of protein desumoylation mitotic nuclear division regulation of cellular component organization regulation of cell cycle process organelle fission regulation of mitotic nuclear division regulation of organelle organization mitotic cell cycle cellular component organization regulation of mitotic cell cycle organelle organization nuclear division mitotic cell cycle process regulation of nuclear division cellular component organization or biogenesis cell cycle regulation of cell cycle cell cycle process cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization protein localization establishment of protein localization protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport	cellular anatomical structure intracellular anatomical structure cytoplasm membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
B	Tyrosine-protein phosphatase CDC14	phosphoric ester hydrolase activity phosphoprotein phosphatase activity non-membrane spanning protein tyrosine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds protein tyrosine phosphatase activity phosphatase activity hydrolase activity catalytic activity histone modifying activity histone phosphatase activity histone H2AXY142 phosphatase activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activity, metal-dependent	cellular process cell cycle mitotic cell cycle regulation of cytokinesis regulation of biological process regulation of cellular process positive regulation of cell division regulation of cell cycle process biological regulation positive regulation of biological process cytokinesis positive regulation of cell cycle regulation of cell division positive regulation of cytokinesis cellular process cell cycle mitotic cell cycle regulation of cytokinesis regulation of biological process regulation of cellular process positive regulation of cell division regulation of cell cycle process biological regulation positive regulation of biological process cytokinesis positive regulation of cell cycle regulation of cell division positive regulation of cytokinesis positive regulation of cell cycle process cell division regulation of cell cycle positive regulation of cellular process cell cycle process regulation of cell cycle phase transition cell cycle phase transition exit from mitosis cellular component organization regulation of mitotic cell cycle cellular component organization or biogenesis mitotic nuclear division organelle fission regulation of mitotic cell cycle phase transition nuclear division organelle organization mitotic cell cycle process regulation of exit from mitosis mitotic cell cycle phase transition chromosome segregation rDNA chromatin condensation nucleolar chromatin organization chromosome organization nucleus organization nucleolus organization chromatin organization chromosome condensation cellular component disassembly spindle disassembly sexual reproduction reproductive process microtubule cytoskeleton organization meiotic cell cycle meiotic spindle organization meiotic cell cycle process meiotic spindle disassembly organelle disassembly microtubule-based process cytoskeleton organization spindle organization catabolic process autophagy metabolic process autophagy of mitochondrion process utilizing autophagic mechanism meiotic nuclear division cellular response to stimulus response to osmotic stress response to stimulus cellular response to chemical stress cellular response to osmotic stress cellular response to environmental stimulus cellular response to chemical stimulus cellular response to stress response to stress response to chemical response to abiotic stimulus cellular response to abiotic stimulus positive regulation of organelle organization regulation of cellular component organization positive regulation of cellular component organization macroautophagy positive regulation of vacuole organization autophagosome organization regulation of autophagy cellular component biogenesis positive regulation of metabolic process cellular component assembly positive regulation of autophagosome assembly positive regulation of macroautophagy positive regulation of autophagy autophagosome assembly organelle assembly vacuole organization positive regulation of cellular component biogenesis regulation of autophagosome assembly regulation of catabolic process regulation of vacuole organization regulation of cellular component biogenesis regulation of organelle organization positive regulation of catabolic process regulation of macroautophagy regulation of organelle assembly regulation of metabolic process positive regulation of organelle assembly assembly of actomyosin apparatus involved in cytokinesis mitotic actomyosin contractile ring assembly regulation of cytokinesis, actomyosin contractile ring assembly regulation of mitotic cytokinetic process mitotic cytokinetic process regulation of mitotic actomyosin contractile ring assembly regulation of mitotic cytokinesis cortical actin cytoskeleton organization actin filament-based process positive regulation of cytokinesis, actomyosin contractile ring assembly assembly of actomyosin apparatus involved in mitotic cytokinesis actomyosin structure organization cortical cytoskeleton organization positive regulation of cytoskeleton organization regulation of cytokinetic process regulation of cytoskeleton organization regulation of actin filament-based process cytoskeleton-dependent cytokinesis positive regulation of mitotic cytokinesis actomyosin contractile ring assembly mitotic cytokinesis positive regulation of mitotic actomyosin contractile ring assembly positive regulation of mitotic cytokinetic process actin cytoskeleton organization regulation of actomyosin structure organization cytokinetic process regulation of actin cytoskeleton organization actomyosin contractile ring organization negative regulation of biological process negative regulation of cellular process chromatin remodeling rDNA heterochromatin formation negative regulation of macromolecule metabolic process regulation of biosynthetic process heterochromatin formation epigenetic regulation of gene expression negative regulation of metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process facultative heterochromatin formation negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process macromolecule metabolic process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process negative regulation of transcription by RNA polymerase I RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase I negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of DNA-templated transcription regulation of transcription by RNA polymerase I primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process regulation of DNA-templated transcription negative regulation of RNA metabolic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen cytoskeleton spindle spindle pole microtubule cytoskeleton cytoplasm mitotic spindle microtubule organizing center spindle pole body mitotic spindle pole body RENT complex protein-containing complex nuclear protein-containing complex chromatin silencing complex new mitotic spindle pole body cellular bud neck cellular bud site of polarized growth

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR040122	Importin beta family	Family
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR041389	Importin repeat 6	Repeat
A	IPR011989	Armadillo-like helical	Homologous Superfamily
A	IPR041653	Importin repeat 4	Repeat
A	IPR040928	Importin repeat	Repeat
B	IPR044506	Dual-specificity phosphatase CDC14, C-terminal	Domain
B	IPR050561	Protein Tyrosine Phosphatase	Family
B	IPR003595	Protein-tyrosine phosphatase, catalytic	Domain
B	IPR029260	Dual specificity/tyrosine protein phosphatase, N-terminal	Domain
B	IPR000340	Dual specificity phosphatase, catalytic domain	Domain
B	IPR016130	Protein-tyrosine phosphatase, active site	Active Site
B	IPR029021	Protein-tyrosine phosphatase-like	Homologous Superfamily
B	IPR000387	Tyrosine-specific protein phosphatases domain	Domain
B	IPR020422	Dual specificity protein phosphatase domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.