5ABM

Sheep aldehyde dehydrogenase 1A1

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5abma_	Alpha and beta proteins (a/b)	ALDH-like	ALDH-like	ALDH-like	automated matches	SHEEP (Ovis aries ) [TaxId: 9940 ],	SCOPe (2.08)
D	d5abmd_	Alpha and beta proteins (a/b)	ALDH-like	ALDH-like	ALDH-like	automated matches	SHEEP (Ovis aries ) [TaxId: 9940 ],	SCOPe (2.08)
B	d5abmb_	Alpha and beta proteins (a/b)	ALDH-like	ALDH-like	ALDH-like	automated matches	SHEEP (Ovis aries ) [TaxId: 9940 ],	SCOPe (2.08)
C	d5abmc_	Alpha and beta proteins (a/b)	ALDH-like	ALDH-like	ALDH-like	automated matches	SHEEP (Ovis aries ) [TaxId: 9940 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ALDH-like	8033027	3001479	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	ALDH-like	8033027	3001479	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ALDH-like	8033027	3001479	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ALDH-like	8033027	3001479	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Aldedh_2nd	e5abmA1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
A	Aldedh_1st_1	e5abmA2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
D	Aldedh_2nd	e5abmD2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
D	Aldedh_1st_1	e5abmD1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
B	Aldedh_2nd	e5abmB1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
B	Aldedh_1st_1	e5abmB2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)
C	Aldedh_2nd	e5abmC1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
C	Aldedh_1st_1	e5abmC2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.605.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 1	CATH (4.3.0)
A	3.40.309.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 2	CATH (4.3.0)
D	3.40.605.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 1	CATH (4.3.0)
D	3.40.309.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 2	CATH (4.3.0)
B	3.40.605.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 1	CATH (4.3.0)
B	3.40.309.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 2	CATH (4.3.0)
C	3.40.605.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 1	CATH (4.3.0)
C	3.40.309.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00171	Aldehyde dehydrogenase family (Aldedh)	Aldehyde dehydrogenase family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	RETINAL DEHYDROGENASE 1	oxidoreductase activity aldehyde dehydrogenase (NAD+) activity oxidoreductase activity, acting on the aldehyde or oxo group of donors 3-deoxyglucosone dehydrogenase activity catalytic activity aldehyde dehydrogenase [NAD(P)+] activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor retinal dehydrogenase activity benzaldehyde dehydrogenase (NAD+) activity benzaldehyde dehydrogenase [NAD(P)+] activity NAD binding binding nucleoside phosphate binding purine nucleotide binding oxidoreductase activity aldehyde dehydrogenase (NAD+) activity oxidoreductase activity, acting on the aldehyde or oxo group of donors 3-deoxyglucosone dehydrogenase activity catalytic activity aldehyde dehydrogenase [NAD(P)+] activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor retinal dehydrogenase activity benzaldehyde dehydrogenase (NAD+) activity benzaldehyde dehydrogenase [NAD(P)+] activity NAD binding binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding adenyl nucleotide binding nucleotide binding heterocyclic compound binding small molecule binding aminobutyraldehyde dehydrogenase (NAD+) activity	cellular response to stimulus cellular detoxification response to stimulus detoxification response to oxygen-containing compound cellular response to oxygen-containing compound response to toxic substance cellular detoxification of aldehyde cellular response to chemical stimulus cellular response to aldehyde response to chemical cellular process cellular response to toxic substance gamma-aminobutyric acid metabolic process cellular response to stimulus cellular detoxification response to stimulus detoxification response to oxygen-containing compound cellular response to oxygen-containing compound response to toxic substance cellular detoxification of aldehyde cellular response to chemical stimulus cellular response to aldehyde response to chemical cellular process cellular response to toxic substance gamma-aminobutyric acid metabolic process small molecule biosynthetic process oxoacid metabolic process carboxylic acid metabolic process amino acid metabolic process primary metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process non-proteinogenic amino acid metabolic process amino acid biosynthetic process biosynthetic process gamma-aminobutyric acid biosynthetic process small molecule metabolic process metabolic process monocarboxylic acid metabolic process non-proteinogenic amino acid biosynthetic process multicellular organismal process multicellular organismal-level homeostasis homeostatic process anatomical structure homeostasis tissue homeostasis maintenance of lens transparency fructosamine catabolic process carbohydrate derivative catabolic process catabolic process amino sugar catabolic process amino sugar metabolic process carbohydrate derivative metabolic process fructosamine metabolic process diterpenoid metabolic process retinoid metabolic process terpenoid metabolic process isoprenoid metabolic process lipid metabolic process regulation of hormone levels organic hydroxy compound metabolic process biological regulation alcohol metabolic process hormone metabolic process olefinic compound metabolic process regulation of biological quality retinol metabolic process primary alcohol metabolic process	cellular anatomical structure synapse cell junction intracellular anatomical structure cytoplasm cytosol axon cell projection neuron projection plasma membrane bounded cell projection

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR015590	Aldehyde dehydrogenase domain	Domain
A, B, C, D	IPR016161	Aldehyde/histidinol dehydrogenase	Homologous Superfamily
A, B, C, D	IPR016162	Aldehyde dehydrogenase, N-terminal	Homologous Superfamily
A, B, C, D	IPR029510	Aldehyde dehydrogenase, glutamic acid active site	Conserved Site
A, B, C, D	IPR016163	Aldehyde dehydrogenase, C-terminal	Homologous Superfamily
A, B, C, D	IPR016160	Aldehyde dehydrogenase, cysteine active site	Conserved Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.