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Data API
5FML
Crystal structure of the endonuclease from the PA subunit of influenza B virus bound to the PB2 subunit NLS peptide
External Resource: Annotation
Domain Annotation: ECOD Classification
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Domain Annotation: ECOD Classification
ECOD Database Homepage
Chains
Family Name
Domain Identifier
Architecture
Possible Homology
Homology
Topology
Family
Provenance Source (Version)
B
Flu_PA_N
e5fmlB1
A: a/b three-layered sandwiches
X: Restriction endonuclease-like
H: Restriction endonuclease-like (From Topology)
T: Restriction endonuclease-like
F: Flu_PA_N
ECOD (1.6)
Gene Ontology: Gene Product Annotation
Gene Ontology Database Homepage
Chains
Polymer
Molecular Function
Biological Process
Cellular Component
A
PB2 SUBUNIT OF INFLUENZA B POLYMERASE
5'-3' RNA polymerase activity
catalytic activity, acting on RNA
catalytic activity, acting on a nucleic acid
RNA polymerase activity
transferase activity
RNA-dependent RNA polymerase activity
nucleotidyltransferase activity
catalytic activity
transferase activity, transferring phosphorus-containing groups
RNA binding
binding
organic cyclic compound binding
nucleic acid binding
symbiont-mediated suppression of host transcription
biological process involved in interspecies interaction between organisms
symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
symbiont-mediated perturbation of host process
modulation of process of another organism
biological process involved in interaction with host
biological process involved in symbiotic interaction
RNA metabolic process
viral life cycle
primary metabolic process
nucleobase-containing compound biosynthetic process
macromolecule biosynthetic process
nucleic acid metabolic process
RNA biosynthetic process
symbiont-mediated suppression of host transcription
biological process involved in interspecies interaction between organisms
symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
symbiont-mediated perturbation of host process
modulation of process of another organism
biological process involved in interaction with host
biological process involved in symbiotic interaction
RNA metabolic process
viral life cycle
primary metabolic process
nucleobase-containing compound biosynthetic process
macromolecule biosynthetic process
nucleic acid metabolic process
RNA biosynthetic process
nucleobase-containing compound metabolic process
nucleic acid biosynthetic process
viral genome replication
biosynthetic process
viral RNA genome replication
viral process
metabolic process
cellular process
macromolecule metabolic process
viral gene expression
cap snatching
negative stranded viral RNA transcription
viral transcription
RNA-templated viral transcription
7-methylguanosine mRNA capping
7-methylguanosine RNA capping
RNA capping
gene expression
mRNA processing
mRNA metabolic process
RNA 5'-end processing
RNA processing
DNA-templated transcription
Less
host intracellular membrane-bounded organelle
host cellular component
host intracellular part
cellular anatomical structure
host cell cytoplasm
host cell part
host intracellular region
host cell mitochondrion
host cell cytoplasm part
host intracellular organelle
host cell nucleus
virion component
B
PA SUBUNIT OF INFLUENZA B POLYMERASE
endonuclease activity
nuclease activity
hydrolase activity, acting on ester bonds
hydrolase activity
catalytic activity
RNA binding
binding
organic cyclic compound binding
nucleic acid binding
cation binding
ion binding
metal ion binding
small molecule binding
symbiont-mediated suppression of host transcription
biological process involved in interspecies interaction between organisms
symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
symbiont-mediated perturbation of host process
modulation of process of another organism
biological process involved in interaction with host
biological process involved in symbiotic interaction
RNA metabolic process
viral life cycle
primary metabolic process
nucleobase-containing compound biosynthetic process
macromolecule biosynthetic process
nucleic acid metabolic process
RNA biosynthetic process
symbiont-mediated suppression of host transcription
biological process involved in interspecies interaction between organisms
symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
symbiont-mediated perturbation of host process
modulation of process of another organism
biological process involved in interaction with host
biological process involved in symbiotic interaction
RNA metabolic process
viral life cycle
primary metabolic process
nucleobase-containing compound biosynthetic process
macromolecule biosynthetic process
nucleic acid metabolic process
RNA biosynthetic process
nucleobase-containing compound metabolic process
nucleic acid biosynthetic process
viral genome replication
biosynthetic process
viral RNA genome replication
viral process
metabolic process
cellular process
macromolecule metabolic process
viral gene expression
cap snatching
negative stranded viral RNA transcription
viral transcription
RNA-templated viral transcription
gene expression
DNA-templated transcription
Less
host intracellular membrane-bounded organelle
host cellular component
host intracellular part
cellular anatomical structure
host cell part
host intracellular region
host cell nucleus
host intracellular organelle
host cell cytoplasm
InterPro: Protein Family Classification
InterPro Database Homepage
Chains
Accession
Name
Type
A
IPR001591
Influenza RNA-dependent RNA polymerase subunit PB2
Family
A
IPR049106
Influenza RNA polymerase PB2, N-terminal region
Domain
A
IPR049115
Influenza RNA polymerase PB2, C-terminal domain
Domain
A
IPR049110
Influenza RNA polymerase PB2, second domain
Domain
A
IPR049114
Influenza RNA polymerase PB2, sixth domain
Domain
A
IPR049113
Polymerase basic protein 2, helical domain
Domain
A
IPR049111
Influenza RNA polymerase PB2, middle domain
Domain
A
IPR048298
Influenza RNA polymerase PB2, CAP binding domain
Domain
A
IPR037258
PB2, C-terminal
Homologous Superfamily
B
IPR001009
Influenza RNA-dependent RNA polymerase subunit PA
Family
B
IPR037534
Polymerase acidic protein
Family
B
IPR038372
Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain
Homologous Superfamily
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