Annotations: 5FYN

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Hanta_G1_2nd	e5fynA2	A: beta barrels	X: SH3	H: Hantavirus structural glycoprotein Gn ectodomain subdomain II (From Topology)	T: Hantavirus structural glycoprotein Gn ectodomain subdomain II	F: Hanta_G1_2nd	ECOD (1.6)
A	Hanta_G1_3rd	e5fynA3	A: beta barrels	X: Hantavirus structural glycoprotein Gn ectodomain subdomain III (From Topology)	H: Hantavirus structural glycoprotein Gn ectodomain subdomain III (From Topology)	T: Hantavirus structural glycoprotein Gn ectodomain subdomain III	F: Hanta_G1_3rd	ECOD (1.6)
A	Hanta_G1_1st	e5fynA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Hanta_G1_1st	ECOD (1.6)
B	Hanta_G1_2nd	e5fynB1	A: beta barrels	X: SH3	H: Hantavirus structural glycoprotein Gn ectodomain subdomain II (From Topology)	T: Hantavirus structural glycoprotein Gn ectodomain subdomain II	F: Hanta_G1_2nd	ECOD (1.6)
B	Hanta_G1_3rd	e5fynB3	A: beta barrels	X: Hantavirus structural glycoprotein Gn ectodomain subdomain III (From Topology)	H: Hantavirus structural glycoprotein Gn ectodomain subdomain III (From Topology)	T: Hantavirus structural glycoprotein Gn ectodomain subdomain III	F: Hanta_G1_3rd	ECOD (1.6)
B	Hanta_G1_1st	e5fynB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Hanta_G1_1st	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01567	Hantavirus glycoprotein Gn, head (Hanta_Gn-H)	Hantavirus glycoprotein Gn, head	The medium (M) genome segment of hantaviruses (family Bunyaviridae) encodes the two virion glycoproteins, Gn and Gc (also known as G1 and G2, respectively), as a polyprotein precursor [1,2,3]. Gn and Gc forms homotetramers (spikes) at the surface of ...	The medium (M) genome segment of hantaviruses (family Bunyaviridae) encodes the two virion glycoproteins, Gn and Gc (also known as G1 and G2, respectively), as a polyprotein precursor [1,2,3]. Gn and Gc forms homotetramers (spikes) at the surface of the virion which attach the virion to host cell receptors including integrin beta3/ITGB3 induce internalisation, predominantly through clathrin-dependent endocytosis [3,4]. This entry represents the N-terminal two-thirds of the Gn glycoprotein ectodomain, denoted as 'head' (Gn-H) [2] which interacts with Gc ectodomain. Release of Gn-H at acid pH induces a further conformational change of the Gc domain II tip which exposes non-polar side chains for insertion into the endosomal membrane [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	PUUMALA VIRUS GN GLYCOPROTEIN	cation binding ion binding binding metal ion binding small molecule binding	viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell virion attachment to host cell biological process involved in interspecies interaction between organisms adhesion of symbiont to host cell viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell symbiont entry into host symbiont-mediated suppression of host signal transduction pathway symbiont-mediated perturbation of host cellular process viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell virion attachment to host cell biological process involved in interspecies interaction between organisms adhesion of symbiont to host cell viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell symbiont entry into host symbiont-mediated suppression of host signal transduction pathway symbiont-mediated perturbation of host cellular process symbiont-mediated perturbation of host process symbiont-mediated suppression of host TRAF-mediated signal transduction symbiont-mediated perturbation of host signal transduction pathway modulation of process of another organism symbiont-mediated perturbation of host defense response symbiont-mediated suppression of host immune response symbiont-mediated suppression of host innate immune response symbiont-mediated perturbation of host immune response symbiont-mediated perturbation of host innate immune response cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cellular process signal transduction cell communication	cellular anatomical structure membrane virion component virion membrane host intracellular membrane-bounded organelle host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region host cell mitochondrion host cell cytoplasm part host intracellular organelle host cell endoplasmic reticulum cellular anatomical structure membrane virion component virion membrane host intracellular membrane-bounded organelle host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region host cell mitochondrion host cell cytoplasm part host intracellular organelle host cell endoplasmic reticulum host cell membrane host cell endomembrane system host cell endoplasmic reticulum membrane host cell Golgi membrane host cell Golgi apparatus host cell surface

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR048791	Glycoprotein Gc, C-terminal, bunyavirales	Domain
A, B	IPR048790	Glycoprotein Gn, base, hantavirus	Domain
A, B	IPR002532	Hantavirus glycoprotein Gc, N-terminal domain	Domain
A, B	IPR012316	ITAM motif, hantavirus type	Domain
A, B	IPR002534	Hantavirus glycoprotein Gn, head	Domain
A, B	IPR016402	Envelope glycoprotein precursor, Hantavirus	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.