5GSY | pdb_00005gsy

Kinesin-8 motor, KIF19A, in the nucleotide-free state complexed with GDP-taxol microtubule

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth K]	SCOP2 Family	Kinesin motor domain	8080216	4004055	SCOP2 (2022-06-29)
A [auth K]	SCOP2 Superfamily	P-loop motor domain	8080217	3002036	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth K]	Kinesin	e5gsyK1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Kinesin	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth K]	PF00225	Kinesin motor domain (Kinesin)	Kinesin motor domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth K]	Kinesin-like protein KIF19	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cytoskeletal protein binding microtubule binding protein binding tubulin binding plus-end-directed microtubule motor activity microtubule motor activity polypeptide conformation or assembly isomerase activity isomerase activity cytoskeletal motor activity macromolecular conformation isomerase activity catalytic activity ATP-dependent activity	microtubule-based movement microtubule-based process cellular process cellular component disassembly plasma membrane bounded cell projection organization protein-containing complex organization cell projection organization microtubule cytoskeleton organization axonemal microtubule depolymerization cytoplasmic microtubule depolymerization protein-containing complex disassembly cytoplasmic microtubule organization cilium disassembly cellular component organization microtubule-based movement microtubule-based process cellular process cellular component disassembly plasma membrane bounded cell projection organization protein-containing complex organization cell projection organization microtubule cytoskeleton organization axonemal microtubule depolymerization cytoplasmic microtubule depolymerization protein-containing complex disassembly cytoplasmic microtubule organization cilium disassembly cellular component organization organelle organization microtubule polymerization or depolymerization organelle disassembly microtubule depolymerization cellular component organization or biogenesis supramolecular fiber organization protein depolymerization cytoskeleton organization cilium organization plus-end specific microtubule depolymerization	membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection intracellular anatomical structure axoneme ciliary plasm intracellular membraneless organelle cytoplasmic region plasma membrane bounded cell projection cytoplasm intracellular organelle cytoskeleton membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection intracellular anatomical structure axoneme ciliary plasm intracellular membraneless organelle cytoplasmic region plasma membrane bounded cell projection cytoplasm intracellular organelle cytoskeleton membraneless organelle cytoplasm polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth K]	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
A [auth K]	IPR001752	Kinesin motor domain	Domain
A [auth K]	IPR027640	Kinesin-like protein	Family
A [auth K]	IPR019821	Kinesin motor domain, conserved site	Conserved Site
A [auth K]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.