Annotations: 5H2V

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	IBN_N	e5h2vA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: IBN_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF18829	Importin repeat 6 (Importin_rep_6)	Importin repeat 6	-	Repeat
A	PF18808	Importin repeat (Importin_rep_4)	Importin repeat	-	Repeat
A	PF18816	Importin repeat (Importin_rep_5)	Importin repeat	-	Repeat
A	PF13513	HEAT-like repeat (HEAT_EZ)	HEAT-like repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Importin subunit beta-3	nuclear import signal receptor activity nucleocytoplasmic carrier activity molecular carrier activity nuclear localization sequence binding signal sequence binding binding peptide binding	regulation of cellular process regulation of protein modification process peptidyl-lysine modification protein desumoylation regulation of primary metabolic process protein modification by small protein removal peptidyl-amino acid modification protein metabolic process regulation of protein modification by small protein conjugation or removal protein modification process regulation of biological process regulation of post-translational protein modification regulation of protein metabolic process biological regulation regulation of cellular process regulation of protein modification process peptidyl-lysine modification protein desumoylation regulation of primary metabolic process protein modification by small protein removal peptidyl-amino acid modification protein metabolic process regulation of protein modification by small protein conjugation or removal protein modification process regulation of biological process regulation of post-translational protein modification regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process macromolecule modification metabolic process cellular process macromolecule metabolic process post-translational protein modification regulation of metabolic process protein modification by small protein conjugation or removal regulation of protein desumoylation mitotic nuclear division regulation of cellular component organization regulation of cell cycle process organelle fission regulation of mitotic nuclear division regulation of organelle organization mitotic cell cycle cellular component organization regulation of mitotic cell cycle organelle organization nuclear division mitotic cell cycle process regulation of nuclear division cellular component organization or biogenesis cell cycle regulation of cell cycle cell cycle process cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization protein localization establishment of protein localization protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization protein localization to organelle protein import into nucleus intracellular protein transport	cellular anatomical structure intracellular anatomical structure cytoplasm membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
B	Ubiquitin-like-specific protease 1	cysteine-type peptidase activity peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity deSUMOylase activity ubiquitin-like protein peptidase activity	peptidyl-lysine modification protein desumoylation primary metabolic process protein modification by small protein removal macromolecule modification peptidyl-amino acid modification metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process post-translational protein modification protein modification by small protein conjugation or removal cell cycle G2/M phase transition peptidyl-lysine modification protein desumoylation primary metabolic process protein modification by small protein removal macromolecule modification peptidyl-amino acid modification metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process post-translational protein modification protein modification by small protein conjugation or removal cell cycle G2/M phase transition mitotic cell cycle process G2/M transition of mitotic cell cycle cell cycle phase transition cell cycle mitotic cell cycle cell cycle process mitotic cell cycle phase transition proteolysis	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen organelle envelope nuclear envelope endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR040122	Importin beta family	Family
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR041389	Importin repeat 6	Repeat
A	IPR011989	Armadillo-like helical	Homologous Superfamily
A	IPR041653	Importin repeat 4	Repeat
A	IPR040928	Importin repeat	Repeat
B	IPR038765	Papain-like cysteine peptidase superfamily	Homologous Superfamily
B	IPR003653	Ulp1 protease family, C-terminal catalytic domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.