5NJJ | pdb_00005njj

PTB domain of human Numb isoform-1

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5njja_	All beta proteins	PH domain-like barrel	PH domain-like	Phosphotyrosine-binding domain (PTB)	Numb	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d5njjb_	All beta proteins	PH domain-like barrel	PH domain-like	Phosphotyrosine-binding domain (PTB)	Numb	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d5njjc_	All beta proteins	PH domain-like barrel	PH domain-like	Phosphotyrosine-binding domain (PTB)	Numb	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d5njjd_	All beta proteins	PH domain-like barrel	PH domain-like	Phosphotyrosine-binding domain (PTB)	Numb	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PID	e5njjA1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PID	ECOD (1.6)
B	PID	e5njjB1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PID	ECOD (1.6)
C	PID	e5njjC1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PID	ECOD (1.6)
D	PID	e5njjD1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PID	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)
B	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)
C	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)
D	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00640	Phosphotyrosine interaction domain (PTB/PID) (PID)	Phosphotyrosine interaction domain (PTB/PID)		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Protein numb homolog	protein binding binding alpha-catenin binding cell adhesion molecule binding cadherin binding beta-catenin binding	adherens junction organization cellular component organization cell junction organization cellular process cellular component organization or biogenesis cell-cell junction organization protein localization regulation of localization cellular localization regulation of cellular process regulation of protein localization negative regulation of biological process negative regulation of protein localization to plasma membrane localization adherens junction organization cellular component organization cell junction organization cellular process cellular component organization or biogenesis cell-cell junction organization protein localization regulation of localization cellular localization regulation of cellular process regulation of protein localization negative regulation of biological process negative regulation of protein localization to plasma membrane localization cellular macromolecule localization negative regulation of cellular process regulation of protein localization to membrane negative regulation of protein localization regulation of biological process protein localization to cell periphery protein localization to plasma membrane biological regulation regulation of protein localization to cell periphery localization within membrane protein localization to membrane negative regulation of protein localization to membrane regulation of cellular localization macromolecule localization negative regulation of protein localization to cell periphery regulation of protein localization to plasma membrane developmental process multicellular organismal process head development lateral ventricle development forebrain development animal organ development brain development nervous system development multicellular organism development central nervous system development ventricular system development anatomical structure development telencephalon development system development axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation plasma membrane bounded cell projection organization axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development positive regulation of locomotion regulation of cell motility positive regulation of biological process positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion positive regulation of cellular process neuroblast proliferation cell proliferation in forebrain cell population proliferation neuroblast division neuroblast division in subventricular zone neural precursor cell proliferation cell division positive regulation of nervous system development regulation of developmental process regulation of cell differentiation regulation of neurogenesis regulation of cell development regulation of nervous system development positive regulation of developmental process positive regulation of cell differentiation positive regulation of neurogenesis regulation of multicellular organismal process regulation of multicellular organismal development positive regulation of cell development positive regulation of multicellular organismal process import into cell regulation of cellular component organization receptor internalization transport postsynaptic neurotransmitter receptor internalization regulation of receptor internalization vesicle-mediated transport vesicle-mediated transport in synapse establishment of localization in cell regulation of postsynaptic neurotransmitter receptor internalization regulation of biological quality regulation of endocytosis regulation of transport regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport establishment of localization protein-containing complex localization neurotransmitter receptor internalization regulation of postsynaptic membrane neurotransmitter receptor levels postsynaptic endocytosis endocytosis receptor-mediated endocytosis	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction clathrin-coated pit membrane endomembrane system apical part of cell membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction clathrin-coated pit membrane endomembrane system apical part of cell membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle clathrin-coated vesicle coated vesicle cytoplasm vesicle cell periphery plasma membrane basal part of cell basal plasma membrane plasma membrane region basolateral plasma membrane synapse glutamatergic synapse early endosome endosome endosome membrane cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane organelle membrane
E, F, G, H	ALA-TYR-ILE-GLY-PRO-PTR-LEU	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR011993	PH-like domain superfamily	Homologous Superfamily
A, B, C, D	IPR006020	PTB/PI domain	Domain
A, B, C, D	IPR016698	Numb/numb-like	Family
A, B, C, D	IPR010449	NUMB domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P49757	astrocytic tumor malignant ependymoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm psoriasis glioblastoma malignant glioma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia rheumatoid arthritis large cell medulloblastoma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma Pick disease tuberculosis

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
E, F, G, H	PTR	Parent Component: TYR RESID: AA0039 PSI-MOD : O4'-phospho-L-tyrosine MOD:00048

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.