5WEH

Cytochrome c oxidase from Rhodobacter sphaeroides in the reduced state

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Cytochrome c oxidase subunit I-like	8040887	3000653	SCOP2B (2022-06-29)
B [auth G]	SCOP2B Superfamily	Cytochrome c oxidase subunit I-like	8040887	3000653	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	Cytochrome c oxidase subunit II-like, transmembrane region	8040896	3000692	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	Cupredoxins	8040891	3000886	SCOP2B (2022-06-29)
F [auth H]	SCOP2B Superfamily	Cytochrome c oxidase subunit II-like, transmembrane region	8040896	3000692	SCOP2B (2022-06-29)
F [auth H]	SCOP2B Superfamily	Cupredoxins	8040891	3000886	SCOP2B (2022-06-29)
D [auth C]	SCOP2B Superfamily	Cytochrome c oxidase subunit III-like	8041605	3000671	SCOP2B (2022-06-29)
G [auth I]	SCOP2B Superfamily	Cytochrome c oxidase subunit III-like	8041605	3000671	SCOP2B (2022-06-29)
H [auth J]	SCOP2B Superfamily	Bacterial aa3 type cytochrome c oxidase subunit IV	8041607	3000704	SCOP2B (2022-06-29)
E [auth D]	SCOP2B Superfamily	Bacterial aa3 type cytochrome c oxidase subunit IV	8041607	3000704	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	COX1	e5wehA1	A: alpha superhelices	X: Cytochrome c oxidase subunit I-like	H: Cytochrome c oxidase subunit I-like (From Topology)	T: Cytochrome c oxidase subunit I-like	F: COX1	ECOD (1.6)
B [auth G]	COX1	e5wehG1	A: alpha superhelices	X: Cytochrome c oxidase subunit I-like	H: Cytochrome c oxidase subunit I-like (From Topology)	T: Cytochrome c oxidase subunit I-like	F: COX1	ECOD (1.6)
C [auth B]	COX2	e5wehB2	A: beta sandwiches	X: Cupredoxin-like	H: Cupredoxin-related (From Topology)	T: Cupredoxin-related	F: COX2	ECOD (1.6)
C [auth B]	COX2_TM	e5wehB1	A: extended segments	X: Cytochrome c oxidase subunit II-like, transmembrane region (From Topology)	H: Cytochrome c oxidase subunit II-like, transmembrane region (From Topology)	T: Cytochrome c oxidase subunit II-like, transmembrane region	F: COX2_TM	ECOD (1.6)
F [auth H]	COX2	e5wehH2	A: beta sandwiches	X: Cupredoxin-like	H: Cupredoxin-related (From Topology)	T: Cupredoxin-related	F: COX2	ECOD (1.6)
F [auth H]	COX2_TM	e5wehH1	A: extended segments	X: Cytochrome c oxidase subunit II-like, transmembrane region (From Topology)	H: Cytochrome c oxidase subunit II-like, transmembrane region (From Topology)	T: Cytochrome c oxidase subunit II-like, transmembrane region	F: COX2_TM	ECOD (1.6)
D [auth C]	COX3	e5wehC1	A: alpha bundles	X: Cytochrome c oxidase subunit III-like (From Topology)	H: Cytochrome c oxidase subunit III-like (From Topology)	T: Cytochrome c oxidase subunit III-like	F: COX3	ECOD (1.6)
G [auth I]	COX3	e5wehI1	A: alpha bundles	X: Cytochrome c oxidase subunit III-like (From Topology)	H: Cytochrome c oxidase subunit III-like (From Topology)	T: Cytochrome c oxidase subunit III-like	F: COX3	ECOD (1.6)
H [auth J]	COX4_pro_2	e5wehJ1	A: extended segments	X: Bacterial aa3 type cytochrome c oxidase subunit IV (From Topology)	H: Bacterial aa3 type cytochrome c oxidase subunit IV (From Topology)	T: Bacterial aa3 type cytochrome c oxidase subunit IV	F: COX4_pro_2	ECOD (1.6)
E [auth D]	COX4_pro_2	e5wehD1	A: extended segments	X: Bacterial aa3 type cytochrome c oxidase subunit IV (From Topology)	H: Bacterial aa3 type cytochrome c oxidase subunit IV (From Topology)	T: Bacterial aa3 type cytochrome c oxidase subunit IV	F: COX4_pro_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.210.10	Mainly Alpha	Up-down Bundle	Cytochrome C Oxidase	Chain A	CATH (4.3.0)
B [auth G]	1.20.210.10	Mainly Alpha	Up-down Bundle	Cytochrome C Oxidase	Chain A	CATH (4.3.0)
C [auth B]	1.10.287.90	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
C [auth B]	2.60.40.420	Mainly Beta	Sandwich	Immunoglobulin-like	Cupredoxins - blue copper proteins	CATH (4.3.0)
F [auth H]	1.10.287.90	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
F [auth H]	2.60.40.420	Mainly Beta	Sandwich	Immunoglobulin-like	Cupredoxins - blue copper proteins	CATH (4.3.0)
D [auth C]	1.10.287.70	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
D [auth C]	1.20.120.80	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Cytochrome c oxidase, subunit III, four-helix bundle	CATH (4.3.0)
G [auth I]	1.10.287.70	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
G [auth I]	1.20.120.80	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Cytochrome c oxidase, subunit III, four-helix bundle	CATH (4.3.0)
H [auth J]	1.20.5.160	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Bacterial aa3 type cytochrome c oxidase subunit IV	CATH (4.3.0)
E [auth D]	1.20.5.160	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Bacterial aa3 type cytochrome c oxidase subunit IV	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth G]	PF00115	Cytochrome C and Quinol oxidase polypeptide I (COX1)	Cytochrome C and Quinol oxidase polypeptide I	-	Family
C [auth B], F [auth H]	PF00116	Cytochrome C oxidase subunit II, periplasmic domain (COX2)	Cytochrome C oxidase subunit II, periplasmic domain	-	Domain
C [auth B], F [auth H]	PF02790	Cytochrome C oxidase subunit II, transmembrane domain (COX2_TM)	Cytochrome C oxidase subunit II, transmembrane domain	-	Family
D [auth C], G [auth I]	PF00510	Cytochrome c oxidase subunit III (COX3)	Cytochrome c oxidase subunit III	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth G]	Cytochrome c oxidase subunit 1	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity cytochrome-c oxidase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreductase activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity oxidoreductase activity, acting on a heme group of donors inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity cytochrome-c oxidase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreductase activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity oxidoreductase activity, acting on a heme group of donors inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity catalytic activity binding organic cyclic compound binding tetrapyrrole binding heme binding cation binding ion binding metal ion binding small molecule binding	electron transport coupled proton transport transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization energy coupled proton transmembrane transport, against electrochemical gradient monoatomic ion transport cellular process monoatomic cation transport electron transport coupled proton transport transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization energy coupled proton transmembrane transport, against electrochemical gradient monoatomic ion transport cellular process monoatomic cation transport aerobic respiration cellular respiration oxidative phosphorylation energy derivation by oxidation of organic compounds metabolic process generation of precursor metabolites and energy respiratory electron transport chain electron transport chain	respiratory chain complex protein-containing complex catalytic complex cytochrome complex membrane membrane protein complex respiratory chain complex IV transporter complex cellular anatomical structure transmembrane transporter complex oxidoreductase complex cell periphery plasma membrane
C [auth B], F [auth H]	Cytochrome c oxidase subunit 2	cation binding transition metal ion binding copper ion binding ion binding binding metal ion binding small molecule binding monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity cytochrome-c oxidase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreductase activity cation binding transition metal ion binding copper ion binding ion binding binding metal ion binding small molecule binding monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity cytochrome-c oxidase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreductase activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity oxidoreductase activity, acting on a heme group of donors inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity catalytic activity	aerobic respiration cellular respiration oxidative phosphorylation energy derivation by oxidation of organic compounds respiratory electron transport chain ATP synthesis coupled electron transport electron transport chain metabolic process cellular process generation of precursor metabolites and energy	cell periphery cellular anatomical structure plasma membrane membrane
D [auth C], G [auth I]	Cytochrome c oxidase polypeptide III (Cytochrome AA3 subunit 3)	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity cytochrome-c oxidase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreductase activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity oxidoreductase activity, acting on a heme group of donors inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity cytochrome-c oxidase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreductase activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity oxidoreductase activity, acting on a heme group of donors inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity catalytic activity	aerobic electron transport chain aerobic respiration cellular respiration oxidative phosphorylation energy derivation by oxidation of organic compounds respiratory electron transport chain electron transport chain metabolic process cellular process generation of precursor metabolites and energy	cell periphery cellular anatomical structure plasma membrane membrane
E [auth D], H [auth J]	Aa3-type cytochrome c oxidase subunit IV	-	-	cellular anatomical structure membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth G]	IPR036927	Cytochrome c oxidase-like, subunit I superfamily	Homologous Superfamily
A, B [auth G]	IPR000883	Cytochrome c oxidase subunit I	Family
A, B [auth G]	IPR023615	Cytochrome c oxidase, subunit I, copper-binding site	Binding Site
A, B [auth G]	IPR023616	Cytochrome c oxidase-like, subunit I domain	Domain
A, B [auth G]	IPR033944	Cytochrome c oxidase subunit I domain	Domain
A, B [auth G]	IPR014241	Cytochrome c oxidase, subunit I bacterial type	Family
C [auth B], F [auth H]	IPR002429	Cytochrome c oxidase subunit II-like C-terminal	Domain
C [auth B], F [auth H]	IPR011759	Cytochrome C oxidase subunit II, transmembrane domain	Domain
C [auth B], F [auth H]	IPR036257	Cytochrome C oxidase subunit II, transmembrane domain superfamily	Homologous Superfamily
C [auth B], F [auth H]	IPR008972	Cupredoxin	Homologous Superfamily
C [auth B], F [auth H]	IPR001505	Copper centre Cu(A)	Binding Site
C [auth B], F [auth H]	IPR045187	Cytochrome c/quinol oxidase subunit II	Family
C [auth B], F [auth H]	IPR014222	Cytochrome c oxidase, subunit II	Domain
D [auth C], G [auth I]	IPR035973	Cytochrome c oxidase subunit III-like superfamily	Homologous Superfamily
D [auth C], G [auth I]	IPR013833	Cytochrome c oxidase, subunit III, 4-helical bundle	Homologous Superfamily
D [auth C], G [auth I]	IPR000298	Cytochrome c oxidase subunit III-like	Domain
D [auth C], G [auth I]	IPR033945	Cytochrome c oxidase subunit III domain	Domain
D [auth C], G [auth I]	IPR024791	Cytochrome c oxidase subunit III	Family
E [auth D], H [auth J]	IPR012422	Cytochrome c oxidase, subunit IV, bacterial aa3 type	Domain
E [auth D], H [auth J]	IPR036596	Bacterial aa3 type cytochrome c oxidase subunit IV superfamily	Homologous Superfamily

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B [auth G], C [auth B], D [auth C], F [auth H] A, B [auth G], C [auth B], D [auth C], F [auth H], G [auth I]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B [auth G], C [auth B], D [auth C], F [auth H] A, B [auth G], C [auth B], D [auth C], F [auth H], G [auth I]	MemProtMD	Annotated as membrane protein by MemProtMD