Annotations: 5Z4J

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PAP_assoc	e5z4jA2	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: PAP/OAS1 substrate-binding domain	F: PAP_assoc	ECOD (1.6)
A	PAP_central_1st_1	e5z4jA1	A: a+b three layers	X: Nucleotidyltransferase-like	H: Nucleotidyltransferase (From Topology)	T: Nucleotidyltransferase	F: PAP_central_1st_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF22600	Poly(A) RNA polymerase, mitochondrial-like, central palm domain (MTPAP-like_central)	Poly(A) RNA polymerase, mitochondrial-like, central palm domain	This domain is found in human Poly(A) RNA polymerase, mitochondrial (MTPAP) and similar proteins from eukaryotes. MTPAP is a noncanonical polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. It contains three domains: a N-termina ...	This domain is found in human Poly(A) RNA polymerase, mitochondrial (MTPAP) and similar proteins from eukaryotes. MTPAP is a noncanonical polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. It contains three domains: a N-terminal domain RL (Pfam:PF17797) and the canonical palm (this entry) and fingers domains. This domain shows a five -stranded beta-sheet with the three catalytic aspartic acid residues located on its surface [6], together with several alpha- helices, forming an alpha-beta configuration.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Terminal uridylyltransferase Tailor	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding uridylyltransferase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid transferase activity RNA uridylyltransferase activity catalytic activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups cation binding metal ion binding	regulation of cellular process catabolic process positive regulation of biological process RNA metabolic process positive regulation of miRNA metabolic process macromolecule catabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process regulation of RNA metabolic process regulation of miRNA metabolic process positive regulation of macromolecule metabolic process regulation of miRNA catabolic process regulation of nucleobase-containing compound metabolic process regulation of cellular process catabolic process positive regulation of biological process RNA metabolic process positive regulation of miRNA metabolic process macromolecule catabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process regulation of RNA metabolic process regulation of miRNA metabolic process positive regulation of macromolecule metabolic process regulation of miRNA catabolic process regulation of nucleobase-containing compound metabolic process miRNA metabolic process RNA catabolic process positive regulation of cellular process regulation of biological process positive regulation of nucleobase-containing compound metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process regulation of catabolic process miRNA catabolic process nucleic acid metabolic process nucleobase-containing compound catabolic process positive regulation of catabolic process positive regulation of RNA metabolic process nucleic acid catabolic process positive regulation of miRNA catabolic process cellular process metabolic process macromolecule metabolic process regulation of metabolic process pre-miRNA processing negative regulation of biological process RNA biosynthetic process nucleic acid biosynthetic process negative regulation of cellular process RNA processing negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process regulatory ncRNA processing regulatory ncRNA-mediated gene silencing regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process miRNA processing regulation of macromolecule biosynthetic process	cellular anatomical structure intracellular anatomical structure cytoplasm
B	RNA (5'-R(UPUPUPU)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR043519	Nucleotidyltransferase superfamily	Homologous Superfamily
A	IPR054708	Poly(A) RNA polymerase, mitochondrial-like, central palm domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.