Annotations: 6C6L

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth D]	ATP-synt_C	e6c6lD1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: ATP-synt_C	ECOD (1.6)
E	ATP-synt_C	e6c6lE1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: ATP-synt_C	ECOD (1.6)
G [auth F]	ATP-synt_C	e6c6lF2	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: ATP-synt_C	ECOD (1.6)
H [auth G]	ATP-synt_C	e6c6lG2	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: ATP-synt_C	ECOD (1.6)
I [auth H]	ATP-synt_C	e6c6lH1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: ATP-synt_C	ECOD (1.6)
J [auth I]	ATP-synt_C	e6c6lI1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: ATP-synt_C	ECOD (1.6)
K [auth J]	ATP-synt_C	e6c6lJ1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: ATP-synt_C	ECOD (1.6)
L [auth K]	ATP-synt_C	e6c6lK2	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: ATP-synt_C	ECOD (1.6)
M [auth L]	ATP-synt_C	e6c6lL1	A: extended segments	X: F1F0 ATP synthase subunit C (From Topology)	H: F1F0 ATP synthase subunit C (From Topology)	T: F1F0 ATP synthase subunit C	F: ATP-synt_C	ECOD (1.6)
F [auth B]	vATP-synt_AC39_3rd	e6c6lB1	A: alpha bundles	X: V-type ATP synthase subunit C	H: V-type ATP synthase subunit C (From Topology)	T: V-type ATP synthase subunit C	F: vATP-synt_AC39_3rd	ECOD (1.6)
F [auth B]	vATP-synt_AC39_1st	e6c6lB2	A: alpha bundles	X: V-type ATP synthase subunit C	H: V-type ATP synthase subunit C (From Topology)	T: V-type ATP synthase subunit C	F: vATP-synt_AC39_1st	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth D]	PF00137	ATP synthase subunit C (ATP-synt_C)	ATP synthase subunit C	This domain is found in the subunit c of ATP synthases and similar sequences from all cellular organisms. It forms two alpha-helices [1-4].	Domain
B [auth C]	PF00137	ATP synthase subunit C (ATP-synt_C)	ATP synthase subunit C	This domain is found in the subunit c of ATP synthases and similar sequences from all cellular organisms. It forms two alpha-helices [1-4].	Domain
C [auth N]	PF20520	V0 complex accessory subunit Ac45/VOA1 transmembrane domain (Ac45-VOA1_TM)	V0 complex accessory subunit Ac45/VOA1 transmembrane domain	This entry represents the transmembrane domain from ER/Golgi membrane proteins including V0 complex accessory subunit Ac45 (ATP6AP1, also known as V-type proton ATPase subunit S1) from animals and the yeast homologue V0 assembly protein 1 (VOA1) whic ...	This entry represents the transmembrane domain from ER/Golgi membrane proteins including V0 complex accessory subunit Ac45 (ATP6AP1, also known as V-type proton ATPase subunit S1) from animals and the yeast homologue V0 assembly protein 1 (VOA1) which are essential for V0 ATPase assembly, stability and function [1,2]. In humans, mutations of ATP6AP1 cause immunodeficiency with hypogammaglobulinemia, hepatopathy and neurocognitive abnormalities [3]. This entry also includes ER membrane BIG1 proteins from yeast, involved in cell wall biogenesis.	Domain
D [auth M]	PF05493	ATP synthase subunit H (ATP_synt_H)	ATP synthase subunit H	-	Family
E, G [auth F], H [auth G], I [auth H], J [auth I], E, G [auth F], H [auth G], I [auth H], J [auth I], K [auth J], L [auth K], M [auth L]	PF00137	ATP synthase subunit C (ATP-synt_C)	ATP synthase subunit C	This domain is found in the subunit c of ATP synthases and similar sequences from all cellular organisms. It forms two alpha-helices [1-4].	Domain
F [auth B]	PF01992	ATP synthase (C/AC39) subunit (vATP-synt_AC39)	ATP synthase (C/AC39) subunit	-	Family
N [auth A]	PF01496	V-type ATPase 116kDa subunit family (V_ATPase_I)	V-type ATPase 116kDa subunit family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth D]	V-type proton ATPase subunit c'	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation intracellular pH reduction Golgi lumen acidification regulation of intracellular pH cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis vesicle organization cellular component organization organelle organization endosome organization cellular component organization or biogenesis endosomal lumen acidification endomembrane system organization vacuolar acidification	membrane-bounded organelle storage vacuole intracellular anatomical structure lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle cellular anatomical structure organelle cytoplasm vacuolar membrane membrane lytic vacuole membrane membrane-bounded organelle storage vacuole intracellular anatomical structure lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle cellular anatomical structure organelle cytoplasm vacuolar membrane membrane lytic vacuole membrane bounding membrane of organelle organelle membrane fungal-type vacuole membrane ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex transporter complex cation-transporting ATPase complex proton-transporting two-sector ATPase complex transmembrane transporter complex Golgi membrane Golgi apparatus endomembrane system vacuolar proton-transporting V-type ATPase, V0 domain proton-transporting V-type ATPase, V0 domain proton-transporting two-sector ATPase complex, proton-transporting domain vacuolar proton-transporting V-type ATPase complex cell periphery
B [auth C]	V-type proton ATPase subunit c''	monoatomic cation transmembrane transporter activity P-type transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity ATPase-coupled monoatomic cation transmembrane transporter activity P-type proton-exporting transporter activity ATP-dependent activity P-type ion transporter activity active monoatomic ion transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity P-type transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity ATPase-coupled monoatomic cation transmembrane transporter activity P-type proton-exporting transporter activity ATP-dependent activity P-type ion transporter activity active monoatomic ion transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled ion transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation intracellular pH reduction Golgi lumen acidification regulation of intracellular pH cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis vesicle organization cellular component organization organelle organization endosome organization cellular component organization or biogenesis endosomal lumen acidification endomembrane system organization vacuolar acidification	vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle cytoplasm organelle membrane fungal-type vacuole membrane ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex transporter complex cation-transporting ATPase complex proton-transporting two-sector ATPase complex transmembrane transporter complex Golgi membrane Golgi apparatus endomembrane system vacuolar proton-transporting V-type ATPase, V0 domain proton-transporting V-type ATPase, V0 domain proton-transporting two-sector ATPase complex, proton-transporting domain vacuolar proton-transporting V-type ATPase complex
C [auth N]	V0 assembly protein 1	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport cellular component organization cellular component biogenesis transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis homeostatic process biological regulation intracellular pH reduction Golgi lumen acidification regulation of intracellular pH cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis vesicle organization organelle organization endosome organization endosomal lumen acidification endomembrane system organization vacuolar acidification	vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle cytoplasm organelle membrane fungal-type vacuole membrane ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex transporter complex cation-transporting ATPase complex proton-transporting two-sector ATPase complex transmembrane transporter complex Golgi membrane Golgi apparatus endomembrane system vacuolar proton-transporting V-type ATPase, V0 domain proton-transporting V-type ATPase, V0 domain proton-transporting two-sector ATPase complex, proton-transporting domain vacuolar proton-transporting V-type ATPase complex organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane
D [auth M]	V-type proton ATPase subunit e	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport cellular component organization cellular component biogenesis transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis homeostatic process biological regulation intracellular pH reduction Golgi lumen acidification regulation of intracellular pH cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis carbohydrate derivative biosynthetic process mannoprotein biosynthetic process cell wall mannoprotein biosynthetic process cell wall organization or biogenesis glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process macromolecule biosynthetic process mannoprotein metabolic process biosynthetic process metabolic process protein metabolic process macromolecule metabolic process cell wall glycoprotein biosynthetic process cell wall macromolecule metabolic process vesicle organization organelle organization endosome organization endosomal lumen acidification endomembrane system organization vacuolar acidification	vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle cytoplasm organelle membrane fungal-type vacuole membrane ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex transporter complex cation-transporting ATPase complex proton-transporting two-sector ATPase complex transmembrane transporter complex Golgi membrane Golgi apparatus endomembrane system vacuolar proton-transporting V-type ATPase, V0 domain proton-transporting V-type ATPase, V0 domain proton-transporting two-sector ATPase complex, proton-transporting domain vacuolar proton-transporting V-type ATPase complex
E, G [auth F], H [auth G], I [auth H], J [auth I], E, G [auth F], H [auth G], I [auth H], J [auth I], K [auth J], L [auth K], M [auth L]	V-type proton ATPase subunit c	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport protein localization establishment of protein localization cellular localization nitrogen compound transport protein targeting establishment of protein localization to vacuole intracellular transport protein localization to vacuole establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization establishment of localization in cell protein localization to organelle vacuolar transport protein targeting to vacuole intracellular protein transport intracellular copper ion homeostasis copper ion homeostasis import into cell endocytosis vesicle-mediated transport biological regulation intracellular pH reduction Golgi lumen acidification regulation of intracellular pH regulation of pH regulation of biological quality regulation of cellular pH vesicle organization cellular component organization organelle organization endosome organization cellular component organization or biogenesis endosomal lumen acidification endomembrane system organization vacuole organization vacuolar acidification	vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle cytoplasm organelle membrane fungal-type vacuole membrane ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex transporter complex cation-transporting ATPase complex proton-transporting two-sector ATPase complex transmembrane transporter complex Golgi membrane Golgi apparatus endomembrane system vacuolar proton-transporting V-type ATPase, V0 domain proton-transporting V-type ATPase, V0 domain proton-transporting two-sector ATPase complex, proton-transporting domain vacuolar proton-transporting V-type ATPase complex
F [auth B]	V-type proton ATPase subunit d	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport cellular localization establishment of localization in cell transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport cellular localization establishment of localization in cell vacuolar transport intracellular transport homeostatic process biological regulation intracellular pH reduction Golgi lumen acidification regulation of intracellular pH cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis vesicle organization cellular component organization organelle organization endosome organization cellular component organization or biogenesis endosomal lumen acidification endomembrane system organization vacuolar acidification	vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle cytoplasm organelle membrane fungal-type vacuole membrane ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex transporter complex cation-transporting ATPase complex proton-transporting two-sector ATPase complex transmembrane transporter complex Golgi membrane Golgi apparatus endomembrane system vacuolar proton-transporting V-type ATPase, V0 domain proton-transporting V-type ATPase, V0 domain proton-transporting two-sector ATPase complex, proton-transporting domain vacuolar proton-transporting V-type ATPase complex
N [auth A]	V-type proton ATPase subunit a, vacuolar isoform	phosphatidylinositol-3,5-bisphosphate binding binding ion binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity phosphatidylinositol-3,5-bisphosphate binding binding ion binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity ATPase binding protein binding enzyme binding	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport cellular component organization cellular component biogenesis transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis protein localization to vacuolar membrane protein localization cellular localization protein localization to vacuole localization within membrane protein localization to membrane cellular macromolecule localization macromolecule localization protein localization to organelle cellular response to stimulus response to stimulus response to pH cellular response to pH response to alkaline pH response to abiotic stimulus cellular response to alkaline pH cellular response to abiotic stimulus cellular response to environmental stimulus response to osmotic stress cellular response to chemical stress cellular response to osmotic stress cellular response to chemical stimulus hyperosmotic response cellular hyperosmotic response cellular response to stress response to stress response to chemical oxoacid metabolic process metabolic process small molecule metabolic process organic acid metabolic process phosphorus metabolic process polyphosphate metabolic process homeostatic process biological regulation intracellular pH reduction regulation of intracellular pH vacuolar acidification cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis	membrane-bounded organelle storage vacuole intracellular anatomical structure lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle cellular anatomical structure organelle cytoplasm vacuolar membrane membrane lytic vacuole membrane membrane-bounded organelle storage vacuole intracellular anatomical structure lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle cellular anatomical structure organelle cytoplasm vacuolar membrane membrane lytic vacuole membrane bounding membrane of organelle organelle membrane fungal-type vacuole membrane ATPase dependent transmembrane transport complex protein-containing complex ATPase complex vacuolar proton-transporting V-type ATPase, V0 domain membrane protein complex proton-transporting V-type ATPase complex transporter complex proton-transporting two-sector ATPase complex proton-transporting V-type ATPase, V0 domain catalytic complex proton-transporting two-sector ATPase complex, proton-transporting domain vacuolar proton-transporting V-type ATPase complex cation-transporting ATPase complex transmembrane transporter complex membrane microdomain membrane raft
O	V-type proton ATPase subunit f	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity proton-transporting ATPase activity, rotational mechanism ATPase-coupled monoatomic cation transmembrane transporter activity ATP-dependent activity active monoatomic ion transmembrane transporter activity ATPase-coupled ion transmembrane transporter activity active transmembrane transporter activity ATPase activity, coupled to transmembrane movement of ions, rotational mechanism inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity endonuclease activity nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on RNA RNA endonuclease activity catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport homeostatic process biological regulation intracellular pH reduction Golgi lumen acidification regulation of intracellular pH cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis vesicle organization cellular component organization organelle organization endosome organization cellular component organization or biogenesis endosomal lumen acidification endomembrane system organization vacuolar acidification	vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle vacuolar membrane membrane-bounded organelle storage vacuole intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle cytoplasm organelle membrane fungal-type vacuole membrane ATPase dependent transmembrane transport complex protein-containing complex ATPase complex catalytic complex membrane protein complex proton-transporting V-type ATPase complex transporter complex cation-transporting ATPase complex proton-transporting two-sector ATPase complex transmembrane transporter complex Golgi membrane Golgi apparatus endomembrane system vacuolar proton-transporting V-type ATPase, V0 domain proton-transporting V-type ATPase, V0 domain proton-transporting two-sector ATPase complex, proton-transporting domain vacuolar proton-transporting V-type ATPase complex organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth D]	IPR035921	F/V-ATP synthase subunit C superfamily	Homologous Superfamily
A [auth D]	IPR002379	V-ATPase proteolipid subunit C-like domain	Domain
A [auth D]	IPR011555	V-ATPase proteolipid subunit C, eukaryotic	Family
A [auth D]	IPR000245	V-ATPase proteolipid subunit	Family
B [auth C]	IPR035921	F/V-ATP synthase subunit C superfamily	Homologous Superfamily
B [auth C]	IPR002379	V-ATPase proteolipid subunit C-like domain	Domain
B [auth C]	IPR000245	V-ATPase proteolipid subunit	Family
C [auth N]	IPR046756	V-type proton ATPase subunit S1/VOA1, transmembrane domain	Domain
D [auth M]	IPR008389	ATPase, V0 complex, subunit e1/e2	Family
E, G [auth F], H [auth G], I [auth H], J [auth I], E, G [auth F], H [auth G], I [auth H], J [auth I], K [auth J], L [auth K], M [auth L]	IPR035921	F/V-ATP synthase subunit C superfamily	Homologous Superfamily
E, G [auth F], H [auth G], I [auth H], J [auth I], E, G [auth F], H [auth G], I [auth H], J [auth I], K [auth J], L [auth K], M [auth L]	IPR002379	V-ATPase proteolipid subunit C-like domain	Domain
E, G [auth F], H [auth G], I [auth H], J [auth I], E, G [auth F], H [auth G], I [auth H], J [auth I], K [auth J], L [auth K], M [auth L]	IPR011555	V-ATPase proteolipid subunit C, eukaryotic	Family
E, G [auth F], H [auth G], I [auth H], J [auth I], E, G [auth F], H [auth G], I [auth H], J [auth I], K [auth J], L [auth K], M [auth L]	IPR000245	V-ATPase proteolipid subunit	Family
F [auth B]	IPR036079	V-type ATP synthase subunit c/d subunit superfamily	Homologous Superfamily
F [auth B]	IPR035067	V-type ATPase subunit C/d	Homologous Superfamily
F [auth B]	IPR044911	V-type ATP synthase c/d subunit, domain 3 superfamily	Homologous Superfamily
F [auth B]	IPR016727	ATPase, V0 complex, subunit d	Family
F [auth B]	IPR002843	ATPase, V0 complex, c/d subunit	Family
N [auth A]	IPR026028	ATPase, V0 complex, subunit 116kDa, eukaryotic	Family
N [auth A]	IPR002490	V-type ATPase, V0 complex, 116kDa subunit family	Family
O	IPR026770	Ribonuclease kappa	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A [auth D], B [auth C], C [auth N], D [auth M], E A [auth D], B [auth C], C [auth N], D [auth M], E, F [auth B], G [auth F], H [auth G], I [auth H], J [auth I], K [auth J], L [auth K], M [auth L], N [auth A], O	OPM	Transmembrane	Alpha-helical polytopic	Proton or Sodium translocating F-type, V-type and A-type ATPases	V-type and F-type ATPases

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A [auth D], B [auth C], C [auth N], D [auth M], E A [auth D], B [auth C], C [auth N], D [auth M], E, F [auth B], G [auth F], H [auth G], I [auth H], J [auth I], K [auth J], L [auth K], M [auth L], N [auth A], O	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A [auth D], B [auth C], C [auth N], D [auth M], E A [auth D], B [auth C], C [auth N], D [auth M], E, F [auth B], G [auth F], H [auth G], I [auth H], J [auth I], K [auth J], L [auth K], M [auth L], N [auth A], O	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A [auth D], B [auth C], C [auth N], D [auth M], E A [auth D], B [auth C], C [auth N], D [auth M], E, F [auth B], G [auth F], H [auth G], I [auth H], J [auth I], K [auth J], L [auth K], M [auth L], N [auth A], O	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Vacuolar ATPase (V-ATPase)	ATPase V_o proton channel reconstituted in nano-discs