6D48 | pdb_00006d48

Cell Surface Receptor

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth E]	d6d48e_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B [auth F]	d6d48f_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth G]	d6d48g_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth H]	d6d48h_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth E]	V-set_11	e6d48E1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_11	ECOD (1.6)
B [auth F]	V-set_11	e6d48F1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_11	ECOD (1.6)
C [auth G]	V-set_11	e6d48G1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_11	ECOD (1.6)
D [auth H]	V-set_11	e6d48H1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_11	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth E]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
B [auth F]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
C [auth G]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
D [auth H]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth E], B [auth F], C [auth G], D [auth H]	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth E], B [auth F], C [auth G], D [auth H]	Myeloid cell surface antigen CD33	sialic acid binding organic acid binding binding ion binding anion binding carboxylic acid binding carbohydrate derivative binding small molecule binding molecular transducer activity signaling receptor activity protein phosphatase binding phosphatase binding protein binding enzyme binding sialic acid binding organic acid binding binding ion binding anion binding carboxylic acid binding carbohydrate derivative binding small molecule binding molecular transducer activity signaling receptor activity protein phosphatase binding phosphatase binding protein binding enzyme binding carbohydrate binding phosphoric ester hydrolase activity enzyme regulator activity protein phosphatase activator activity catalytic activity, acting on a protein phosphatase activator activity molecular function activator activity phosphatase activity phosphatase regulator activity hydrolase activity phosphoprotein phosphatase activity enzyme activator activity protein tyrosine phosphatase activator activity hydrolase activity, acting on ester bonds molecular function regulator activity protein tyrosine phosphatase activity protein phosphatase regulator activity catalytic activity	multicellular organismal process regulation of tumor necrosis factor production regulation of cellular process negative regulation of biological process negative regulation of tumor necrosis factor production cytokine production regulation of cytokine production negative regulation of cellular process regulation of multicellular organismal process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process negative regulation of metabolic process biological regulation multicellular organismal process regulation of tumor necrosis factor production regulation of cellular process negative regulation of biological process negative regulation of tumor necrosis factor production cytokine production regulation of cytokine production negative regulation of cellular process regulation of multicellular organismal process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process negative regulation of metabolic process biological regulation tumor necrosis factor superfamily cytokine production negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process tumor necrosis factor production regulation of gene expression negative regulation of gene expression regulation of tumor necrosis factor superfamily cytokine production biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of tumor necrosis factor superfamily cytokine production metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process negative regulation of multicellular organismal process regulation of metabolic process cellular response to stimulus immune response-regulating cell surface receptor signaling pathway response to stimulus cell surface receptor signaling pathway signaling immune response cell communication Fc receptor signaling pathway immune response-regulating signaling pathway regulation of response to stimulus immune system process regulation of immune response regulation of immune system process signal transduction Fc-gamma receptor signaling pathway monocyte activation regulation of leukocyte activation cell activation regulation of cell activation negative regulation of monocyte activation myeloid leukocyte activation leukocyte activation negative regulation of cell activation negative regulation of immune system process negative regulation of leukocyte activation interleukin-1 production regulation of interleukin-1 beta production negative regulation of interleukin-1 beta production negative regulation of interleukin-1 production regulation of interleukin-1 production interleukin-1 beta production cell-cell signaling protein localization regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of protein localization transport positive regulation of biological process positive regulation of establishment of protein localization positive regulation of secretion by cell protein localization to extracellular region positive regulation of protein transport localization regulation of secretion by cell secretion by cell positive regulation of secretion cellular macromolecule localization positive regulation of cellular process regulation of transport secretion regulation of establishment of protein localization establishment of protein localization to extracellular region export from cell regulation of protein transport protein secretion establishment of localization positive regulation of protein secretion regulation of protein secretion regulation of secretion positive regulation of transport protein transport regulation of cellular localization macromolecule localization positive regulation of protein localization negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation cell adhesion negative regulation of interleukin-8 production interleukin-8 production regulation of interleukin-8 production cell-cell adhesion immune response-inhibiting signal transduction	membrane-bounded organelle intracellular anatomical structure tertiary granule membrane membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system tertiary granule intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure bounding membrane of organelle vesicle membrane cytoplasmic vesicle membrane-bounded organelle intracellular anatomical structure tertiary granule membrane membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system tertiary granule intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle organelle membrane secretory granule membrane specific granule membrane specific granule cell periphery cell surface plasma membrane external side of plasma membrane side of membrane nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen Golgi apparatus peroxisome microbody

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth E], B [auth F], C [auth G], D [auth H]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A [auth E], B [auth F], C [auth G], D [auth H]	IPR013106	Immunoglobulin V-set domain	Domain
A [auth E], B [auth F], C [auth G], D [auth H]	IPR003599	Immunoglobulin domain subtype	Domain
A [auth E], B [auth F], C [auth G], D [auth H]	IPR013151	Immunoglobulin-like beta-sandwich domain	Domain
A [auth E], B [auth F], C [auth G], D [auth H]	IPR051036	Sialic acid-binding Ig-like lectin	Family
A [auth E], B [auth F], C [auth G], D [auth H]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A [auth E], B [auth F], C [auth G], D [auth H]	IPR007110	Immunoglobulin-like domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth E], B [auth F], C [auth G], D [auth H]	Pharos: P20138	acute myeloid leukemia Alzheimer disease Acute Confusional Senile Dementia cancer lung carcinoma osteosarcoma lymphatic system disease bone marrow disease glioblastoma non-small cell lung carcinoma tuberculosis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.