6JKS | pdb_00006jks

Crystal structure of aspartate transcarbamoylase from Trypanosoma cruzi in complex with carbamoyl phosphate (CP) and aspartate (Asp)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6jksa1	Alpha and beta proteins (a/b)	ATC-like	Aspartate/ornithine carbamoyltransferase	automated matches	automated matches	(Trypanosoma cruzi strain CL Brener ) [TaxId: 353153 ],	SCOPe (2.08)
B	d6jksb1	Alpha and beta proteins (a/b)	ATC-like	Aspartate/ornithine carbamoyltransferase	automated matches	automated matches	(Trypanosoma cruzi strain CL Brener ) [TaxId: 353153 ],	SCOPe (2.08)
B	d6jksb3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Trypanosoma cruzi strain CL Brener ) [TaxId: 353153 ],	SCOPe (2.08)
C	d6jksc1	Alpha and beta proteins (a/b)	ATC-like	Aspartate/ornithine carbamoyltransferase	automated matches	automated matches	(Trypanosoma cruzi strain CL Brener ) [TaxId: 353153 ],	SCOPe (2.08)
C	d6jksc3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Trypanosoma cruzi strain CL Brener ) [TaxId: 353153 ],	SCOPe (2.08)
D	d6jksd1	Alpha and beta proteins (a/b)	ATC-like	Aspartate/ornithine carbamoyltransferase	automated matches	automated matches	(Trypanosoma cruzi strain CL Brener ) [TaxId: 353153 ],	SCOPe (2.08)
D	d6jksd3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Trypanosoma cruzi strain CL Brener ) [TaxId: 353153 ],	SCOPe (2.08)
E	d6jkse1	Alpha and beta proteins (a/b)	ATC-like	Aspartate/ornithine carbamoyltransferase	automated matches	automated matches	(Trypanosoma cruzi strain CL Brener ) [TaxId: 353153 ],	SCOPe (2.08)
F	d6jksf1	Alpha and beta proteins (a/b)	ATC-like	Aspartate/ornithine carbamoyltransferase	automated matches	automated matches	(Trypanosoma cruzi strain CL Brener ) [TaxId: 353153 ],	SCOPe (2.08)
F	d6jksf3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Trypanosoma cruzi strain CL Brener ) [TaxId: 353153 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	OTCace	e6jksA1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Aspartate/ornithine carbamoyltransferase	F: OTCace	ECOD (1.6)
A	OTCace_N	e6jksA2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Aspartate/ornithine carbamoyltransferase	F: OTCace_N	ECOD (1.6)
B	OTCace	e6jksB1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Aspartate/ornithine carbamoyltransferase	F: OTCace	ECOD (1.6)
B	OTCace_N	e6jksB2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Aspartate/ornithine carbamoyltransferase	F: OTCace_N	ECOD (1.6)
C	OTCace	e6jksC2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Aspartate/ornithine carbamoyltransferase	F: OTCace	ECOD (1.6)
C	OTCace_N	e6jksC1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Aspartate/ornithine carbamoyltransferase	F: OTCace_N	ECOD (1.6)
D	OTCace	e6jksD2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Aspartate/ornithine carbamoyltransferase	F: OTCace	ECOD (1.6)
D	OTCace_N	e6jksD1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Aspartate/ornithine carbamoyltransferase	F: OTCace_N	ECOD (1.6)
E	OTCace	e6jksE2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Aspartate/ornithine carbamoyltransferase	F: OTCace	ECOD (1.6)
E	OTCace_N	e6jksE1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Aspartate/ornithine carbamoyltransferase	F: OTCace_N	ECOD (1.6)
F	OTCace	e6jksF2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Aspartate/ornithine carbamoyltransferase	F: OTCace	ECOD (1.6)
F	OTCace_N	e6jksF1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Aspartate/ornithine carbamoyltransferase	F: OTCace_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1370	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Aspartate/ornithine carbamoyltransferase	CATH (utative)
B	3.40.50.1370	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Aspartate/ornithine carbamoyltransferase	CATH (utative)
C	3.40.50.1370	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Aspartate/ornithine carbamoyltransferase	CATH (utative)
D	3.40.50.1370	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Aspartate/ornithine carbamoyltransferase	CATH (utative)
E	3.40.50.1370	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Aspartate/ornithine carbamoyltransferase	CATH (utative)
F	3.40.50.1370	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Aspartate/ornithine carbamoyltransferase	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF02729	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain (OTCace_N)	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain		Domain
A, B, C, D, E A, B, C, D, E, F	PF00185	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain (OTCace)	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Aspartate carbamoyltransferase, putative	aspartate carbamoyltransferase activity carboxyl- or carbamoyltransferase activity transferase activity, transferring one-carbon groups transferase activity catalytic activity binding amino acid binding	pyrimidine-containing compound metabolic process nucleobase biosynthetic process pyrimidine nucleobase biosynthetic process primary metabolic process nucleobase-containing compound metabolic process pyrimidine nucleobase metabolic process biosynthetic process nucleobase-containing small molecule metabolic process nucleobase metabolic process 'de novo' pyrimidine nucleobase biosynthetic process small molecule metabolic process metabolic process cellular process pyrimidine-containing compound biosynthetic process pyrimidine-containing compound metabolic process nucleobase biosynthetic process pyrimidine nucleobase biosynthetic process primary metabolic process nucleobase-containing compound metabolic process pyrimidine nucleobase metabolic process biosynthetic process nucleobase-containing small molecule metabolic process nucleobase metabolic process 'de novo' pyrimidine nucleobase biosynthetic process small molecule metabolic process metabolic process cellular process pyrimidine-containing compound biosynthetic process ribose phosphate metabolic process nucleotide biosynthetic process carbohydrate derivative metabolic process pyrimidine nucleotide metabolic process 'de novo' UMP biosynthetic process ribonucleotide biosynthetic process UMP biosynthetic process ribonucleotide metabolic process ribonucleoside monophosphate metabolic process phosphate-containing compound metabolic process UMP metabolic process phosphorus metabolic process nucleoside monophosphate metabolic process ribose phosphate biosynthetic process pyrimidine ribonucleotide metabolic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process pyrimidine nucleoside monophosphate metabolic process pyrimidine ribonucleoside monophosphate metabolic process nucleobase-containing compound biosynthetic process nucleotide metabolic process nucleoside monophosphate biosynthetic process pyrimidine ribonucleoside monophosphate biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process pyrimidine nucleoside monophosphate biosynthetic process ribonucleoside monophosphate biosynthetic process pyrimidine nucleotide biosynthetic process pyrimidine ribonucleotide biosynthetic process amino acid metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR006132	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding	Domain
A, B, C, D, E A, B, C, D, E, F	IPR006131	Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR036901	Aspartate/ornithine carbamoyltransferase superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR006130	Aspartate/ornithine carbamoyltransferase	Family
A, B, C, D, E A, B, C, D, E, F	IPR002082	Aspartate carbamoyltransferase	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.